(R)-2-PHENYLPIPERIDINE
- Product Name
- (R)-2-PHENYLPIPERIDINE
- CAS No.
- 58613-54-0
- Chemical Name
- (R)-2-PHENYLPIPERIDINE
- Synonyms
- (R)-2-PHENYLPIPERIDINE;(2R)-2-phenylpiperidine;(R)-(+)-6-phenylpiperidine;(R)-2-Phenylpiperidine 95%;Piperidine, 2-phenyl-, (2R)-
- CBNumber
- CB9407604
- Molecular Formula
- C11H15N
- Formula Weight
- 161.24
- MOL File
- Mol file
(R)-2-PHENYLPIPERIDINE Property
- Boiling point:
- 257.3±19.0 °C(Predicted)
- Density
- 0.967±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- liquid
- pka
- 9.74±0.10(Predicted)
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 900573
- Product name
- (R)-2-Phenylpiperidine
- Purity
- 95%
- Packaging
- 1G
- Price
- $697
- Updated
- 2023/06/20
- Product number
- 900573
- Product name
- (R)-2-Phenylpiperidine
- Purity
- 95%
- Packaging
- 5G
- Price
- $1020
- Updated
- 2023/01/07
- Product number
- P400183
- Product name
- (R)-2-Phenylpiperidine
- Packaging
- 100mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- 121952
- Product name
- (R)-2-Phenylpiperidine
- Purity
- >97%
- Packaging
- 500mg
- Price
- $441
- Updated
- 2021/12/16
- Product number
- AS116333
- Product name
- (R)-2-Phenylpiperidine
- Purity
- 97+% ee
- Packaging
- 1g
- Price
- $478
- Updated
- 2021/12/16
(R)-2-PHENYLPIPERIDINE Chemical Properties,Usage,Production
Description
(R)-2-Phenylpiperidine is an alkene that has been used in the desymmetrization of secondary amides to produce enantiopure products. It has been shown to be stereoselective. It could prepared from δ-Amino β-keto esters 3. The kinetic resolution of this compound is due to the formation of an enamine, which undergoes a 1,4-addition reaction with an aldoxime or piperidone.
Uses
Chiral building block developed using Liverpool ChiroChem-patented technology.
Synthesis
In a 10 mL one-necked round-bottomed flask equipped with a magnetic stir bar, rubber septum, and argon balloon was placed 0.033 g (0.19 mmol, 1 equiv.) of (R)-(+)-6-Phenylpiperidin-2-one and THF (1.2 mL). Lithium aluminum hydride (0.95 mL, 1.0 M solution in THF, 0.95 mmol) was added slowly via syringe and the reaction mixture was stirred at rt for 8 h. The solution was cooled to 0 °C, sat. Na2SO4 (0.17 mL) was added, stirred for 0.5 h at rt and the reaction mixture was filtered through Celite. The organic phases were concentrated and flash chromatography (7% MeOH/CH2Cl2) gave 0.025 g (82%) of (R)-2-phenylpiperidine as volatile oil.
(R)-2-PHENYLPIPERIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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