3-(4-FLUOROBENZOYL)PROPIONIC ACID

Product Name: 3-(4-FLUOROBENZOYL)PROPIONIC ACID
CAS No.: 366-77-8
Chemical Name: 3-(4-FLUOROBENZOYL)PROPIONIC ACID
Synonyms: R 11302;AKOS BBS-00006441;LABOTEST-BB LT00233221;HALOPERIDOL METABOLITE III;3-(4-FLUOROBENZOYL)PROPIONIC ACID;4-Fluoro-oxo-benzenebutanoic acid;4-Fluoro-γ-oxobenzenebutyric acid;β-(p-Fluorobenzoyl)propionic acid;3-(4-Fluorobenzoyl)propanoic acid;4-(4-fluorophenyl)-4-oxobutanoate
CBNumber: CB9412884
Molecular Formula: C10H9FO3
Formula Weight: 196.18
MOL File: 366-77-8.mol

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3-(4-FLUOROBENZOYL)PROPIONIC ACID Property

Melting point:: 100-102 °C (lit.)
Boiling point:: 374.4±22.0 °C(Predicted)
Density: 1.2441 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: powder to crystal
pka: 4.50±0.17(Predicted)
color: White to Orange to Green
Water Solubility: Insoluble in water.
BRN: 958145
CAS DataBase Reference: 366-77-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,C,Xi
Risk Statements: 36/37/38-20/21/22-22
Safety Statements: 36/37/39-26-22-24/25
WGK Germany: 3
Hazard Note: Corrosive
HazardClass: IRRITANT
HS Code: 29183000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: F0379
Product name: 3-(4-Fluorobenzoyl)propionic Acid
Purity: >97.0%(GC)(T)
Packaging: 5g
Price: $84
Updated: 2025/07/31

TCI Chemical

Product number: F0379
Product name: 3-(4-Fluorobenzoyl)propionic Acid
Purity: >97.0%(GC)(T)
Packaging: 25g
Price: $293
Updated: 2025/07/31

TRC

Product number: F632283
Product name: 4-(4-Fluorophenyl)-4-oxobutanoicAcid
Packaging: 2.5g
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: J96811
Product name: 4-(4-Fluorophenyl)-4-oxobutanoicacid
Packaging: 1g
Price: $10
Updated: 2021/12/16

Matrix Scientific

Product number: 005951
Product name: 3-(4-Fluorobenzoyl)propionic acid
Purity: 97%
Packaging: 5g
Price: $18
Updated: 2021/12/16

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3-(4-FLUOROBENZOYL)PROPIONIC ACID Chemical Properties,Usage,Production

Chemical Properties

beige granular powder

Uses

7-Fluoro-1-tetralone was prepared from 3-(4-fluorobenzoyl)-propionic acid by Wolff-Kishner reduction followed by ring closure with polyphosphoric acid and other substituted 1-tetralones where commercially available. Reduction of 3-(4-fluorobenzoyl)propionic acid with an excess of tert-butylamine borane (TBAB) in the presence of AlCl3 provided 4-(4-fluorophenyl)-1-butanol (87) in 63% yield for the synthesis of LM-1507 sodium salt. Penfluridol 1-[4,4-bis(4-fluorophenyl)butyl]-4-(4-chloro-3-trifluoromethylphenyl)- 4-hydroxypiperidine, C 28 H 27 ClF 5 NO, M r 523.99, mp 105 - 107°C, is obtained by reducing the ketone of 3-(4-fluorobenzoyl)propionic acid into a lactone.

Definition

ChEBI: 4-(4-Fluorophenyl)-4-oxobutanoic acid is an aromatic ketone.

General Description

3-(4-Fluorobenzoyl)propionic acid is a metabolite of haloperidol, a dopamine D2 receptor blocker.

Synthesis

108-30-5

462-06-6

366-77-8

1. aluminum chloride (2.66 g, 20 mmol) was slowly added to a stirred mixture of succinic anhydride (1.00 g, 10 mmol) and fluorobenzene (5.6 mL, 60 mmol) at -5 °C. 2. the reaction temperature was maintained at -5 °C for 1 hour, followed by a slow warming to room temperature, and the reaction continued for 17 hours. 3. the reaction mixture was slowly poured into a stirred 18% HCl aqueous solution (30 mL) at 0 °C and stirring was continued for 30 min while the mixture was allowed to gradually warm up to room temperature. 4. The resulting white powder was collected by filtration and washed with deionized water. 5. The product was 4-(4-(4-hydroxyphenyl)ethyl)ethyl). 5. The product was 4-(4-fluorophenyl)-4-oxobutyric acid in 1.67 g, 85% yield. 6. ; HPLC tR = 1.53 min (>99% purity, mobile phase is an aqueous solution of 80% MeCN).

References

[1] Helvetica Chimica Acta, 1995, vol. 78, # 3, p. 647 - 662
[2] Patent: WO2007/96647, 2007, A2. Location in patent: Page/Page column 148-149
[3] Patent: CN107556287, 2018, A. Location in patent: Paragraph 0036; 0037; 0038; 0039; 0040; 0052; 0053
[4] Patent: CN106187863, 2016, A. Location in patent: Paragraph 0153; 0154; 0155; 0156; 0157; 0104-0108
[5] Tetrahedron Letters, 2016, vol. 57, # 24, p. 2583 - 2586

3-(4-FLUOROBENZOYL)PROPIONIC ACID Preparation Products And Raw materials

Raw materials

Fluorobenzene Succinic anhydride

Preparation Products

IMAZODAN

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3-(4-FLUOROBENZOYL)PROPIONIC ACID Suppliers

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View Lastest Price from 3-(4-FLUOROBENZOYL)PROPIONIC ACID manufacturers

Career Henan Chemical Co

Product: 3-(4-FLUOROBENZOYL)PROPIONIC ACID 366-77-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-30

366-77-8, 3-(4-FLUOROBENZOYL)PROPIONIC ACIDRelated Search:

3-(2',4'-DIFLUOROBENZOYL)PROPIONIC ACID METHYL 4-(4-FLUOROPHENYL)-2,4-DIOXOBUTANOATE 3-(4-FLUOROBENZOYL)PROPIONIC ACID Haloperidol ethyl 4-(2,4-difluorophenyl)-2,4-dioxobutanoate TRANS-2-(4-FLUOROBENZOYL)CYCLOPENTANE-1-CARBOXYLIC ACID 2-METHYL-4-OXO-4-(4'-FLUOROPHENYL)BUTYRIC ACID 4-(3,4-DIFLUOROPHENYL)-4-OXOBUTYRIC ACID TRANS-2-(4-FLUOROBENZOYL)-1-CYCLOHEXANE-CARBOXYLIC ACID, 99 CIS-2-(4-FLUOROBENZOYL)-1-CYCLOHEXANE-CARBOXYLIC ACID, 99 ETHYL 4-(3,4-DIFLUOROPHENYL)-2,2-DIMETHYL-4-OXOBUTYRATE ETHYL 4-(4-FLUOROPHENYL)-4-OXOBUTYRATE CIS-2-(4-FLUOROBENZOYL)CYCLOPENTANE-1-CARBOXYLIC ACID ETHYL 4-(3,4-DIFLUOROPHENYL)-4-OXOBUTYRATE 4-OXO-4-(3,4,5-TRIFLUOROPHENYL)BUTYRIC ACID ETHYL 4-(2,4-DIFLUOROPHENYL)-4-OXOBUTYRATE ETHYL 4-OXO-4-(3,4,5-TRIFLUOROPHENYL)BUTYRATE 4-(4-fluorophenyl)-4-oxo-2-[(2-thienylmethyl)amino]butanoic acid

HALOPERIDOL METABOLITE III

LABOTEST-BB LT00233221

3-(4'-FLUOROBENZOYL)PROPIONIC ACID

3-(4-FLUOROBENZOYL)PROPIONIC ACID

4-(4-FLUOROPHENYL)-4-OXOBUTANOIC ACID

4-(4-FLUOROPHENYL)-4-OXOBUTYRIC ACID

AKOS BBS-00006441

4-FLUORO-R-OXO-BENZENEBUTANOIC ACID

Benzenebutanoic acid, 4-fluoro-.gamma.-oxo-

3-(4-Fluorobenzoyl)propionic acid 97%

3-(4-Fluorobenzoyl)propionicacid97%

beta-(4-fluorobenzoyl)propionic acid

4-Fluoro-oxo-benzenebutanoic acid

R 11302

Haloperidol metabolite III, R 11302

4-Fluoro-γ-oxobenzenebutyric acid

4-Oxo-4-(4-fluorophenyl)butyric acid

β-(p-Fluorobenzoyl)propionic acid

3-(4-Fluorobenzoyl)propanoic acid 97%

3-(4-Fluorobenzoyl)propionic acid, 98%+

3-(4-Fluorobenzoyl)propanoic acid

3-(p-Fluorobenzoyl)-propionic acid

4-(4-fluorophenyl)-4-keto-butyric acid

3-(4-Fluorobenzoyl)propionic Acid 3-(4-

4-(4-Fluorophenyl)-4-oxobutanoic acid 97%

4-(4-fluorophenyl)-4-oxobutanoate

3-(4-Fluorobenzoyl)propionicAcid&gt

Benzenebutanoic acid, 4-fluoro-γ-oxo-

3-(4-Fluorobenzoyl)-propionic acid, 1mg/ml in Methanol

366-77-8

FC6H4COCH2CH2CO2H

CARBOXYLIC ACID

Building Blocks

C10

Carboxylic Acids

Carbonyl Compounds

Organic Building Blocks

Aromatic Building Blocks

Aromatic Propionic Acids

Acids & Esters

Fluorine Compounds