Propargylcholine

Product Name: Propargylcholine
CAS No.: 111755-76-1
Chemical Name: Propargylcholine
Synonyms: Propargylcholine;Propargylcholine (bromide);Alkyne-choline (hydrobromide);Propargylcholine, 10 mM in DMSO;(2-HYDROXYETHYL)DIMETHYL(PROP-2-YN-1-YL)AZANIUM BROMIDE;N-(2-hydroxyethyl)-N,N-dimethylprop-2-yn-1-aminium bromide;N-(2-hydroxyethyl)-N,N-dimethyl-2-propyn-1-aminium,monobromide;2-Propyn-1-aminium, N-(2-hydroxyethyl)-N,N-dimethyl-, bromide (1:1)
CBNumber: CB94200319
Molecular Formula: C7H14BrNO
Formula Weight: 208.09616
MOL File: 111755-76-1.mol

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Propargylcholine Property

storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
form: A crystalline solid
color: Off-white to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 25870
Product name: Propargylcholine (bromide)
Purity: ≥95%
Packaging: 10mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 25870
Product name: Propargylcholine (bromide)
Purity: ≥95%
Packaging: 50mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 25870
Product name: Propargylcholine (bromide)
Purity: ≥95%
Packaging: 100mg
Price: $347
Updated: 2024/03/01

Cayman Chemical

Product number: 25870
Product name: Propargylcholine (bromide)
Purity: ≥95%
Packaging: 250mg
Price: $780
Updated: 2024/03/01

Matrix Scientific

Product number: 174729
Product name: N-(2-Hydroxyethyl)-N,N-dimethyl-2-propyn-1-ammonium bromide
Packaging: 5g
Price: $1206
Updated: 2021/12/16

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Propargylcholine Chemical Properties,Usage,Production

Description

Propargylcholine bromide is an alkynyl derivative of choline that has a propargyl group in place of one methyl group. It can be used to assay phospholipid synthesis and localization in cells and tissues using Raman scattering microscopy or click chemistry labeling with fluorescent or affinity-tagged azides.

Uses

Propargylcholine bromide is a choline analogue containing terminal propargyl that can be incorporated into all classes of Choline-containing phospholipids such as phosphatidylcholine and sphingomyelin, labeling Choline-containing phospholipids. Propargylcholine bromide-labeled phospholipid molecules can be visualized in cells with high sensitivity and spatial resolution. Propargylcholine bromide can be used as a molecular tool to study the biochemical and metabolic processes of Choline-containing phospholipids in cells[1][2]. Propargylcholine (bromide) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

in vivo

Propargylcholine bromide (P-Cho; 3.5-4.0 mg/kg; i.p; single daily for 6 days) effectively incorporates into newly synthesized myelin within 1 week of dosing and sustained presence beyond 6 weeks in rhesus monkey^[2].

References

[1] Jao CY, et al. Metabolic labeling and direct imaging of choline phospholipids in vivo. Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15332-7. DOI:10.1073/pnas.0907864106
[2] Karen R. Bottenfield, et al. Optimization of Propargylcholine to Label Newly Synthesized Myelin in the Rhesus Monkey Brain. FASEB J. 2020, 34(S1): 1-1.

Propargylcholine Preparation Products And Raw materials

Raw materials

Preparation Products

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Propargylcholine Suppliers

China 27 United Kingdom 1 United States 3 Global 31

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View Lastest Price from Propargylcholine manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Alkyne-choline (hydrobromide) 111755-76-1
Price: US $0.00/mg
Min. Order: 10mg
Purity: >95.00%
Supply Ability: 10mg
Release date: 2024-03-21

111755-76-1, PropargylcholineRelated Search:

Propargylcholine

2-Propyn-1-aminium, N-(2-hydroxyethyl)-N,N-dimethyl-, bromide (1:1)

Propargylcholine (bromide)

(2-HYDROXYETHYL)DIMETHYL(PROP-2-YN-1-YL)AZANIUM BROMIDE

Alkyne-choline (hydrobromide)

N-(2-hydroxyethyl)-N,N-dimethyl-2-propyn-1-aminium,monobromide

N-(2-hydroxyethyl)-N,N-dimethylprop-2-yn-1-aminium bromide

Propargylcholine, 10 mM in DMSO

111755-76-1