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Inflachromene

Product Name
Inflachromene
CAS No.
908568-01-4
Chemical Name
Inflachromene
Synonyms
ICM;Inflachromene;Inflachromene (ICM);5,12b-dihydro-10-hydroxy-7,7-dimethyl-2-phenyl-1H,7H-[1]benzopyrano[4,3-c][1,2,4]triazolo[1,2-a]pyridazine-1,3(2H)-dione;1H,7H-[1]Benzopyrano[4,3-c][1,2,4]triazolo[1,2-a]pyridazine-1,3(2H)-dione, 5,12b-dihydro-10-hydroxy-7,7-dimethyl-2-phenyl-
CBNumber
CB94200546
Molecular Formula
C21H19N3O4
Formula Weight
377.39
MOL File
908568-01-4.mol
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Inflachromene Property

Boiling point:
532.6±60.0 °C(Predicted)
Density 
1.50±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF:30.0(Max Conc. mg/mL);79.49(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);79.49(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.53(Max Conc. mM)
Ethanol:2.5(Max Conc. mg/mL);6.62(Max Conc. mM)
form 
A crystalline solid
pka
9.65±0.40(Predicted)
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17006
Product name
Inflachromene
Purity
≥95%
Packaging
5mg
Price
$147
Updated
2026/04/30
Cayman Chemical
Product number
17006
Product name
Inflachromene
Purity
≥95%
Packaging
10mg
Price
$234
Updated
2026/04/30
Cayman Chemical
Product number
17006
Product name
Inflachromene
Purity
≥95%
Packaging
25mg
Price
$543
Updated
2026/04/30
Cayman Chemical
Product number
17006
Product name
Inflachromene
Purity
≥95%
Packaging
5mg
Price
$133
Updated
2024/03/01
Cayman Chemical
Product number
17006
Product name
Inflachromene
Purity
≥95%
Packaging
10mg
Price
$212
Updated
2024/03/01
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Inflachromene Chemical Properties,Usage,Production

Uses

Inflachromene is a novel microglial inhibitor, which binds to HMGB1 (High Mobility Group Box 1) and HMGB2 (High mobility Group Box 2) inhibiting microglia-mediated neuroinflammation.

in vivo

Inflachromene (2-10 mg/kg; i.p. once daily for 4 days) effectively blocks LPS-mediated microglial activation[2].
Inflachromene (10 mg/kg; i.p. once daily for 30 days) significantly reduces the progression of disease, as determined by EAE clinical score[2].
Inflachromene (1 mg/kg; i.v.) exhibits long half-life (14.1±6.43 h) and moderate Vss (2.02±1.02 L/kg)[1].
Inflachromene (1 mg/kg; p.o.) exhibits high oral bioavailability (94%) and Cmax (0.59±0.16 g/mL)[1].

Animal Model:Male C57BL/6 mice (11 weeks; 25-30 g) are treated with LPS[2]
Dosage:2, 10 mg/kg
Administration:I.p. once daily for 4 days
Result:Blocked LPS-mediated microglial activation, even at a dose of 2 mg/kg.
Animal Model:Sprague-Dawley (SD) rats (7 weeks; 230-250 g)[1]
Dosage:1 mg/kg (Pharmacokinetic Analysis)
Administration:I.v. and p.o. administration
Result:I.v.: t1/2=14.1±6.43 h; CL= 0.14±0.01 L/kg/h; Vss=2.02±1.02 L/kg.
P.o.: t1/2=7.96±1.16 h; F=94%; Cmax=0.59±0.16 g/mL.

Inflachromene Preparation Products And Raw materials

Raw materials

Preparation Products

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Inflachromene Suppliers

China 23 United Kingdom 1 United States 4 Global 28
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD
Tel
13816107857
Fax
qq: 276312098
Email
sales@fortunechem-sh.com
Country
China
ProdList
982
Advantage
58
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29661
Advantage
68
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32467
Advantage
58
Shanghai Dongyang Biotechnology Co., Ltd.
Tel
0512-13601744364 13601744364
Email
chemsharker@126.com
Country
China
ProdList
1149
Advantage
58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
+86-0519-85788828 +86-13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
4032
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
Country
China
ProdList
4510
Advantage
58
cjbscvictory
Tel
13348960310 13348960310
Email
3003867561@qq.com
Country
China
ProdList
10343
Advantage
58

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  • Inflachromene
  • Inflachromene (ICM)
  • 5,12b-dihydro-10-hydroxy-7,7-dimethyl-2-phenyl-1H,7H-[1]benzopyrano[4,3-c][1,2,4]triazolo[1,2-a]pyridazine-1,3(2H)-dione
  • ICM
  • 1H,7H-[1]Benzopyrano[4,3-c][1,2,4]triazolo[1,2-a]pyridazine-1,3(2H)-dione, 5,12b-dihydro-10-hydroxy-7,7-dimethyl-2-phenyl-
  • 908568-01-4