ChemicalBook > CAS DataBase List > 1,8-NAPHTHYRIDIN-2-AMINE

1,8-NAPHTHYRIDIN-2-AMINE

Product Name
1,8-NAPHTHYRIDIN-2-AMINE
CAS No.
15992-83-3
Chemical Name
1,8-NAPHTHYRIDIN-2-AMINE
Synonyms
1,8-PHTHYRIDIN-2-AMINE;8-naphthyridin-2-amine;1,8-NAPHTHYRIDIN-2-AMINE;1,8-Naphthyridin-2-amine - [D94656]
CBNumber
CB9425792
Molecular Formula
C8H7N3
Formula Weight
145.16
MOL File
15992-83-3.mol
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1,8-NAPHTHYRIDIN-2-AMINE Property

Melting point:
139-141 °C(Solv: ethanol (64-17-5))
Boiling point:
322.6±22.0 °C(Predicted)
Density 
1.292±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
solid
pka
5.09±0.30(Predicted)
color 
Off-white to light yellow
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
N373545
Product name
1,8-Naphthyridin-2-amine
Packaging
100mg
Price
$90
Updated
2021/12/16
AK Scientific
Product number
W3473
Product name
1,8-Naphthyridin-2-amine
Packaging
250mg
Price
$118
Updated
2021/12/16
Apolloscientific
Product number
OR928440
Product name
1,8-Naphthyridin-2-amine
Purity
98%
Packaging
250mg
Price
$200
Updated
2021/12/16
AK Scientific
Product number
W3473
Product name
1,8-Naphthyridin-2-amine
Packaging
1g
Price
$253
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-1-PS
Product name
1,8-Naphthyridin-2-amine
Purity
98%
Packaging
250mg
Price
$320
Updated
2021/12/16
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1,8-NAPHTHYRIDIN-2-AMINE Chemical Properties,Usage,Production

Synthesis

141-86-6

102-52-3

15992-83-3

To a reaction flask equipped with a stirrer was added 107 g of 2,6-diaminopyridine and 1070 ml of phosphoric acid, to which 241 g of 1,1,3,3-tetramethoxypropane was slowly added dropwise at room temperature. Subsequently, the reaction mixture was heated in an oil bath maintaining the internal temperature at 70-75°C and the reaction lasted for 40 minutes. Upon completion of the reaction, the mixture was poured into 5 liters of ice-cooled aqueous 5 M sodium hydroxide solution and the pH was adjusted to greater than 10. The precipitate was collected by filtration and washed twice with 200 ml of water. The filtrate was extracted twice with dichloromethane, 300 ml each. the combined dichloromethane phases were dried over 100 g of anhydrous sodium sulfate, filtered and concentrated to dryness. The crude product was purified by column chromatography using alumina as stationary phase and a solvent mixture of dichloromethane and methanol (100:1, v/v) as eluent, resulting in 102 g of red solid 1,8-naphthyridin-2-amine in 72% yield and 96% HPLC purity.

References

[1] Patent: CN105399739, 2016, A. Location in patent: Paragraph 0019; 0020
[2] Angewandte Chemie - International Edition, 2017, vol. 56, # 12, p. 3349 - 3353
[3] Angew. Chem., 2017, vol. 129, p. 3397 - 3401,5
[4] Journal of Heterocyclic Chemistry, 1997, vol. 34, # 3, p. 765 - 771

1,8-NAPHTHYRIDIN-2-AMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,8-NAPHTHYRIDIN-2-AMINE Suppliers

China 67 Germany 1 India 2 Ukraine 1 United Kingdom 2 United States 12 Global 85
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View Lastest Price from 1,8-NAPHTHYRIDIN-2-AMINE manufacturers

Career Henan Chemical Co
Product
1,8-NAPHTHYRIDIN-2-AMINE 15992-83-3
Price
US $1.00/KG
Min. Order
1KG
Purity
98% HPLC
Supply Ability
10 tons
Release date
2020-02-01

15992-83-3, 1,8-NAPHTHYRIDIN-2-AMINERelated Search:

5,6,7,8-TETRAHYDRO-6-(PHEHYLMETHYL)-1,6-NAPHTHYRIDIN-3-AMINE 1,5-NAPHTHYRIDIN-4-AMINE Hemp seed protein 5,7-DIMETHYL[1,8]NAPHTHYRIDIN-2-AMINE 7-amino-4-methyl-1,8-naphthyridin-2-ol 1,6-NAPHTHYRIDIN-2-AMINE 7-chloro-1,8-naphthyridin-2-amine N-PIPERIDIN-4-YL-2-(TRIFLUOROMETHYL)-1,6-NAPHTHYRIDIN-5-AMINE HYDROCHLORIDE MONOHYDRATE N-(4-METHOXYBENZYL)-5,7-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDIN-2-AMINE N-(4-CHLOROBENZYL)-5,7-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDIN-2-AMINE N-PHENYL-5,7-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDIN-2-AMINE N-(3-METHOXYPROPYL)-5,7-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDIN-2-AMINE 7-[4-(4-CHLOROPHENYL)PIPERAZINO]-2,4-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDINE 5,7-BIS(TRIFLUOROMETHYL)-N-[3-(TRIFLUOROMETHYL)PHENYL][1,8]NAPHTHYRIDIN-2-AMINE 7-HYDRAZINO-2,4-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDINE 7-MORPHOLINO-2,4-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDINE N-(4-CHLOROPHENYL)-5,7-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDIN-2-AMINE N-(4-PHENOXYPHENYL)-5,7-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDIN-2-AMINE

  • 1,8-NAPHTHYRIDIN-2-AMINE
  • 8-naphthyridin-2-amine
  • 1,8-PHTHYRIDIN-2-AMINE
  • 1,8-Naphthyridin-2-amine - [D94656]
  • 15992-83-3