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2-BENZYLOXY-5-CHLOROPHENYLBORONIC ACID

Product Name
2-BENZYLOXY-5-CHLOROPHENYLBORONIC ACID
CAS No.
612832-83-4
Chemical Name
2-BENZYLOXY-5-CHLOROPHENYLBORONIC ACID
Synonyms
oxy-5-chL;AKOS BRN-0228;2-BENZYLOXY-5-CHLOROPHENYLBORONIC ACID;2-BENZYLOXY-5-CHLOROBENZENEBORONIC ACID;(5-chloro-2-phenylmethoxyphenyl)boronic acid;Boronic acid, B-[5-chloro-2-(phenylmethoxy)phenyl]-;Boronicacid, [5-chloro-2-(phenylmethoxy)phenyl]- (9CI);BORONICACID, [5-CHLORO-2-(PHENYLMETHOXY)PHENYL]- (9CI);;2-Benzyloxy-5-chlorophenylboronic Acid (contains varying amounts of Anhydride)
CBNumber
CB9426865
Molecular Formula
C13H12BClO3
Formula Weight
262.5
MOL File
612832-83-4.mol
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2-BENZYLOXY-5-CHLOROPHENYLBORONIC ACID Property

Melting point:
108-110° C
Boiling point:
462.3±55.0 °C(Predicted)
Density 
1.30±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
powder to crystal
pka
7.60±0.53(Predicted)
color 
White to Almost white
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Safety

Hazard Codes 
C
Hazard Note 
Corrosive
HazardClass 
IRRITANT
HS Code 
2931900090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B5076
Product name
2-Benzyloxy-5-chlorophenylboronic Acid (contains varying amounts of Anhydride)
Packaging
1g
Price
$125
Updated
2025/07/31
TRC
Product number
B700065
Product name
2-Benzyloxy-5-chlorophenylboronicacid
Packaging
1g
Price
$160
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB147553
Product name
2-Benzyloxy-5-chlorophenylboronicacid
Packaging
500mg
Price
$165
Updated
2021/12/16
SynQuest Laboratories
Product number
6760-5-02
Product name
2-Benzyloxy-5-chlorobenzeneboronic acid
Packaging
1g
Price
$192
Updated
2021/12/16
Chem-Impex
Product number
40214
Product name
2-Benzyloxy-5-chlorophenylboronicacid,95-105%(Assaybytitration)
Purity
95-105%(Assaybytitration)
Packaging
1G
Price
$142.11
Updated
2021/12/16
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2-BENZYLOXY-5-CHLOROPHENYLBORONIC ACID Chemical Properties,Usage,Production

Uses

suzuki reaction

Synthesis

100398-25-2

612832-83-4

2-Benzyloxy-5-chlorophenyl iodide (5 g, 0.0145 mol) was used as a raw material in a solvent mixture of ether/tetrahydrofuran (100:30) and cooled to 0 °C to -100 °C. Under nitrogen protection, n-butyllithium (1.6 M hexane solution, 10 mL, 0.016 mol) was added slowly and dropwise over 15 min. Subsequently, the reaction mixture was warmed to -70 °C and kept for 1 hour. Continuing under nitrogen protection, triethyl borate (9 mL, 0.03 mol) was added dropwise. The cooling bath was removed and the reaction mixture was allowed to stir overnight at room temperature. Upon completion of the reaction, the reaction was quenched with 2N hydrochloric acid (40mL) and stirred vigorously for 1 hour at room temperature. The product was extracted with ethyl acetate, dried over magnesium sulfate and the solvent was evaporated to obtain the oil. Finally, the target product 2-benzyloxy-5-chlorophenylboronic acid (2.8 g, 74% yield) was purified by a Biotage purification system (90 g column) using ether/isohexane (50:50) as eluent.

References

[1] Patent: WO2003/84917, 2003, A1. Location in patent: Page/Page column 25
[2] Patent: WO2005/37786, 2005, A1. Location in patent: Page/Page column 41
[3] Patent: WO2004/39753, 2004, A2. Location in patent: Page 49-50
[4] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 10, p. 2666 - 2671
[5] Patent: WO2005/37794, 2005, A1. Location in patent: Page/Page column 26

2-BENZYLOXY-5-CHLOROPHENYLBORONIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2-BENZYLOXY-5-CHLOROPHENYLBORONIC ACID Suppliers

Americas 1 CHINA 72 Europe 1 Germany 3 India 4 Japan 1 Russia 1 United Kingdom 3 United States 17 Global 103
CHIMMED Company
Tel
--
Fax
--
Email
synthesis@chimmed.ru
Country
Russia
ProdList
5006
Advantage
81
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View Lastest Price from 2-BENZYLOXY-5-CHLOROPHENYLBORONIC ACID manufacturers

Career Henan Chemical Co
Product
2-BENZYLOXY-5-CHLOROPHENYLBORONIC ACID 612832-83-4
Price
US $1.00/KG
Min. Order
1KG
Purity
98%-100%
Supply Ability
1
Release date
2018-08-12

612832-83-4, 2-BENZYLOXY-5-CHLOROPHENYLBORONIC ACIDRelated Search:

2-(Benzyloxy)-5-chloropyridin-3-ylboronic acid 5-Benzyloxy-2-chlorophenylboronic acid 2-Benzyloxy-3-chlorophenylboronic acid AKOS BRN-1021 3-Benzyloxy-5-chlorophenylboronic acid 4-BENZYLOXY-3-CHLOROPHENYLBORONIC ACID 4-(BENZYLOXY)-2-CHLOROPHENYLBORONIC ACID 2-Benzyloxyphenylboronic acid 5-CHLORO-2-ETHOXYPHENYLBORONIC ACID 5-Chloro-2-methoxyphenylboronic acid 2-BENZYLOXY-5-CHLOROPHENYLBORONIC ACID 2-ETHOXYPHENYLBORONIC ACID 5-CHLORO-2-HYDROXYPHENYLBORONIC ACID

  • 2-BENZYLOXY-5-CHLOROBENZENEBORONIC ACID
  • 2-BENZYLOXY-5-CHLOROPHENYLBORONIC ACID
  • AKOS BRN-0228
  • Boronicacid, [5-chloro-2-(phenylmethoxy)phenyl]- (9CI)
  • BORONICACID, [5-CHLORO-2-(PHENYLMETHOXY)PHENYL]- (9CI);
  • 2-Benzyloxy-5-chlorophenylboronic Acid (contains varying amounts of Anhydride)
  • (5-chloro-2-phenylmethoxyphenyl)boronic acid
  • oxy-5-chL
  • Boronic acid, B-[5-chloro-2-(phenylmethoxy)phenyl]-
  • 612832-83-4
  • blocks
  • BoronicAcids