3'-O-(T-BUTYLDIMETHYLSILYL)THYMIDINE

Product Name: 3'-O-(T-BUTYLDIMETHYLSILYL)THYMIDINE
CAS No.: 40733-27-5
Chemical Name: 3'-O-(T-BUTYLDIMETHYLSILYL)THYMIDINE
Synonyms: 3'-O-TBDMS-dT;3'-O-TBDMS-2'-dT;3'-O-(TBDMS)THYMIDINE;3’-O-t-Bulyldimethylsilyl thymidine;3'-O-t-BulyldiMethylsilyl thyMidine;3'-O-(T-BUTYLDIMETHYLSILYL)THYMIDINE;3'-O-(tert-ButyldiMethylsilyl)thyMidine;3'-O-[tert-Butyl(dimethyl)silyl]thymidine;3'-O-tert-butyldiMethylsilyl-2'-deoxythyMidine;Thymidine, 3'-O-[(1,1-dimethylethyl)dimethylsilyl]-
CBNumber: CB9431227
Molecular Formula: C16H28N2O5Si
Formula Weight: 356.49
MOL File: 40733-27-5.mol

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3'-O-(T-BUTYLDIMETHYLSILYL)THYMIDINE Property

Melting point:: 93-94 °C
Density: 1.17±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 9.55±0.10(Predicted)
form: Solid
color: White to off-white
optical activity: 22.1° (C=0.01 g/ml, CHCL3)
InChI: InChI=1S/C16H28N2O5Si/c1-10-8-18(15(21)17-14(10)20)13-7-11(12(9-19)22-13)23-24(5,6)16(2,3)4/h8,11-13,19H,7,9H2,1-6H3,(H,17,20,21)/t11-,12+,13+/m0/s1
InChIKey: QAPSNMNOIOSXSQ-YNEHKIRRSA-N
SMILES: OC[C@H]1O[C@@H](N2C=C(C)C(=O)NC2=O)C[C@@H]1O[Si](C(C)(C)C)(C)C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D5997
Product name: 3'-O-[tert-Butyl(dimethyl)silyl]thymidine
Packaging: 250MG
Price: $94
Updated: 2026/03/19

TCI Chemical

Product number: D5997
Product name: 3'-O-[tert-Butyl(dimethyl)silyl]thymidine
Packaging: 1G
Price: $233
Updated: 2026/03/19

TRC

Product number: T296278
Product name: 3''-O-(TBDMS)Thymidine
Packaging: 10mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB144782
Product name: 3’-O-t-Bulyldimethylsilyl thymidine
Packaging: 25mg
Price: $50
Updated: 2021/12/16

Ark Pharm

Product number: P000239862
Product name: 1-((2R,4S,5R)-4-((tert-Butyldimethylsilyl)oxy)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Purity: 97%
Packaging: 100mg
Price: $53
Updated: 2021/12/16

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3'-O-(T-BUTYLDIMETHYLSILYL)THYMIDINE Chemical Properties,Usage,Production

Description

3'-O-[tert-Butyl(dimethyl)silyl]thymidine is a nucleoside analog that is chemically stable and has been shown to be a potential biomarker for the diagnosis of fetal bovine spongiform encephalopathy (BSE). 3'-O-t-Bulyldimethylsilyl thymidine binds to basic proteins in the cell nucleus and has been shown to inhibit protein synthesis in tubule cells of the kidney and skin cancer cells.

Uses

3’-O-t-Bulyldimethylsilylthymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

References

[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005

3'-O-(T-BUTYLDIMETHYLSILYL)THYMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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3'-O-(T-BUTYLDIMETHYLSILYL)THYMIDINE Suppliers

China 55 India 1 United Kingdom 1 United States 5 Global 62

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View Lastest Price from 3'-O-(T-BUTYLDIMETHYLSILYL)THYMIDINE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 3'-O-(T-BUTYLDIMETHYLSILYL)THYMIDINE 40733-27-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-26

40733-27-5, 3'-O-(T-BUTYLDIMETHYLSILYL)THYMIDINERelated Search:

3',5'-BIS-O-(T-BUTYLDIMETHYLSILYL)THYMIDINE 3'-O-(T-BUTYLDIMETHYLSILYL)THYMIDINE

3'-O-(T-BUTYLDIMETHYLSILYL)THYMIDINE

3'-O-(TBDMS)THYMIDINE

1-((2R,4S,5R)-4-((tert-Butyldimethylsilyl)oxy)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

3'-O-(tert-ButyldiMethylsilyl)thyMidine

3'-O-tert-butyldiMethylsilyl-2'-deoxythyMidine

3'-O-t-BulyldiMethylsilyl thyMidine

3'-O-TBDMS-dT

Thymidine, 3'-O-[(1,1-dimethylethyl)dimethylsilyl]-

3'-O-TBDMS-2'-dT

3’-O-t-Bulyldimethylsilyl thymidine

3'-O-[tert-Butyl(dimethyl)silyl]thymidine

40733-27-5

Nucleotides