4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACID
- Product Name
- 4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACID
- CAS No.
- 7206-70-4
- Chemical Name
- 4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACID
- Synonyms
- Benzoic acid, 4-aMino-5-chloro-2-Methoxy-;EU-0018508;AURORA 22274;Oprea1_036404;A1961/0082485;TimTec1_000243;340871_ALDRICH;EINECS 230-582-3;TIMTEC-BB SBB003531;LABOTEST-BB LT00012595
- CBNumber
- CB9434798
- Molecular Formula
- C8H8ClNO3
- Formula Weight
- 201.61
- MOL File
- 7206-70-4.mol
4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACID Property
- Melting point:
- 206 °C (dec.) (lit.)
- Boiling point:
- 369.7±42.0 °C(Predicted)
- Density
- 1.3639 (rough estimate)
- refractive index
- 1.5800 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Powder
- pka
- 4.38±0.10(Predicted)
- color
- White to slightly beige
- InChI
- InChI=1S/C8H8ClNO3/c1-13-7-3-6(10)5(9)2-4(7)8(11)12/h2-3H,10H2,1H3,(H,11,12)
- InChIKey
- RVEATKYEARPWRE-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC(Cl)=C(N)C=C1OC
- CAS DataBase Reference
- 7206-70-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 340871
- Product name
- 4-Amino-5-chloro-2-methoxybenzoic acid
- Purity
- 95%
- Packaging
- 5g
- Price
- $33.48
- Updated
- 2025/07/31
- Product number
- PHR2507
- Product name
- Metoclopramide Impurity C
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 100 mg
- Price
- $521.55
- Updated
- 2025/07/31
- Product number
- 340871
- Product name
- 4-Amino-5-chloro-2-methoxybenzoic acid
- Purity
- 95%
- Packaging
- 25g
- Price
- $133
- Updated
- 2025/07/31
- Product number
- A1237
- Product name
- 4-Amino-5-chloro-o-anisic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $75
- Updated
- 2025/07/31
- Product number
- A1237
- Product name
- 4-Amino-5-chloro-o-anisic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 500g
- Price
- $706
- Updated
- 2025/07/31
4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACID Chemical Properties,Usage,Production
Chemical Properties
WHITE TO SLIGHTLY BEIGE POWDER
Uses
4-Amino-5-chloro-2-methoxybenzoic Acid (Metoclopramide EP Impurity C) is a Metoclopramide (M338685) metabolite.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
20896-27-9
7206-70-4
The general procedure for the synthesis of 4-amino-5-chloro-2-methoxybenzoic acid using methyl 4-amino-5-chloro-2-methoxybenzoate as the raw material was as follows: (3) The above obtained methyl 4-amino-5-chloro-2-methoxybenzoate was mixed with potassium hydroxide at a molar ratio of 1:2.2, and stirred at reflux in a solvent mixture of 7 liters of methanol and water (in a ratio of 5:2, v/v) for more than 2 hours. Activated carbon was then added for decolorization and refluxing was continued for 30 minutes. After completion of the reaction, the activated carbon was removed by filtration. The filtrate was concentrated on a rotary evaporator to remove most of the solvent and then diluted by adding water. The pH was slowly adjusted to 5 with a 3 mol/L hydrochloric acid solution, at which point a white solid precipitated from the aqueous solution. The solid product was collected by filtration and dried to give 1.93 kg of 4-amino-5-chloro-2-methoxybenzoic acid in 91.4% yield. The structure of the product can be confirmed by hydrogen spectroscopy (Figure 1).
References
[1] Patent: CN105237422, 2016, A. Location in patent: Paragraph 0018; 0022
[2] Organic Preparations and Procedures International, 1992, vol. 24, # 1, p. 64 - 66
[3] Journal of Molecular Structure, 1988, vol. 172, p. 381 - 394
4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACID manufacturers
- Product
- 4-Amino-5-chloro-2-methoxybenzoic acid 7206-70-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-19
- Product
- 4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACID 7206-70-4
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Cutomized
- Release date
- 2018-12-22