ChemicalBook > CAS DataBase List > 4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACID

4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACID

Product Name
4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACID
CAS No.
7206-70-4
Chemical Name
4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACID
Synonyms
Benzoic acid, 4-aMino-5-chloro-2-Methoxy-;EU-0018508;AURORA 22274;Oprea1_036404;A1961/0082485;TimTec1_000243;340871_ALDRICH;EINECS 230-582-3;TIMTEC-BB SBB003531;LABOTEST-BB LT00012595
CBNumber
CB9434798
Molecular Formula
C8H8ClNO3
Formula Weight
201.61
MOL File
7206-70-4.mol
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4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACID Property

Melting point:
206 °C (dec.) (lit.)
Boiling point:
369.7±42.0 °C(Predicted)
Density 
1.3639 (rough estimate)
refractive index 
1.5800 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Powder
pka
4.38±0.10(Predicted)
color 
White to slightly beige
InChI
InChI=1S/C8H8ClNO3/c1-13-7-3-6(10)5(9)2-4(7)8(11)12/h2-3H,10H2,1H3,(H,11,12)
InChIKey
RVEATKYEARPWRE-UHFFFAOYSA-N
SMILES
C(O)(=O)C1=CC(Cl)=C(N)C=C1OC
CAS DataBase Reference
7206-70-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HS Code 
29225090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
340871
Product name
4-Amino-5-chloro-2-methoxybenzoic acid
Purity
95%
Packaging
5g
Price
$33.48
Updated
2025/07/31
Sigma-Aldrich
Product number
PHR2507
Product name
Metoclopramide Impurity C
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
100 mg
Price
$521.55
Updated
2025/07/31
Sigma-Aldrich
Product number
340871
Product name
4-Amino-5-chloro-2-methoxybenzoic acid
Purity
95%
Packaging
25g
Price
$133
Updated
2025/07/31
TCI Chemical
Product number
A1237
Product name
4-Amino-5-chloro-o-anisic Acid
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$75
Updated
2025/07/31
TCI Chemical
Product number
A1237
Product name
4-Amino-5-chloro-o-anisic Acid
Purity
>98.0%(HPLC)(T)
Packaging
500g
Price
$706
Updated
2025/07/31
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4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACID Chemical Properties,Usage,Production

Chemical Properties

WHITE TO SLIGHTLY BEIGE POWDER

Uses

4-Amino-5-chloro-2-methoxybenzoic Acid (Metoclopramide EP Impurity C) is a Metoclopramide (M338685) metabolite.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

20896-27-9

7206-70-4

The general procedure for the synthesis of 4-amino-5-chloro-2-methoxybenzoic acid using methyl 4-amino-5-chloro-2-methoxybenzoate as the raw material was as follows: (3) The above obtained methyl 4-amino-5-chloro-2-methoxybenzoate was mixed with potassium hydroxide at a molar ratio of 1:2.2, and stirred at reflux in a solvent mixture of 7 liters of methanol and water (in a ratio of 5:2, v/v) for more than 2 hours. Activated carbon was then added for decolorization and refluxing was continued for 30 minutes. After completion of the reaction, the activated carbon was removed by filtration. The filtrate was concentrated on a rotary evaporator to remove most of the solvent and then diluted by adding water. The pH was slowly adjusted to 5 with a 3 mol/L hydrochloric acid solution, at which point a white solid precipitated from the aqueous solution. The solid product was collected by filtration and dried to give 1.93 kg of 4-amino-5-chloro-2-methoxybenzoic acid in 91.4% yield. The structure of the product can be confirmed by hydrogen spectroscopy (Figure 1).

References

[1] Patent: CN105237422, 2016, A. Location in patent: Paragraph 0018; 0022
[2] Organic Preparations and Procedures International, 1992, vol. 24, # 1, p. 64 - 66
[3] Journal of Molecular Structure, 1988, vol. 172, p. 381 - 394

4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACID Suppliers

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View Lastest Price from 4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACID manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
4-Amino-5-chloro-2-methoxybenzoic acid 7206-70-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-19
Career Henan Chemical Co
Product
4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACID 7206-70-4
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
Cutomized
Release date
2018-12-22

7206-70-4, 4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACIDRelated Search:

Hexyl benzoate 5-Aminosalicylic acid 5-Chloro-2-methoxybenzoic acid 4-Amino-5-chloro-2-methoxybenzoic acid 2-(diethylamino)ethyl ester METOCLOPRAMIDE HCL IMP. C (EP):4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACID 4-Amino-5-chloro-2-methoxybenzoic acid 4-benzylmorpholin-2-ylmethyl ester N-ACETYL-4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACID, METHYL ESTER 4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACID, TECH

  • 4-AMino-5-chloro-2-Methoxybenzoic acid, 98+% 25GR
  • 5-Chloro-4-aMino-2-ethoxybenzoic acid
  • 5-Chloro-4-aMino-2-Methoxybenzoic Acid
  • Benzoic acid, 4-aMino-5-chloro-2-Methoxy-
  • A1961/0082485
  • EINECS 230-582-3
  • EU-0018508
  • InChI=1/C8H8ClNO3/c1-13-7-3-6(10)5(9)2-4(7)8(11)12/h2-3H,10H2,1H3,(H,11,12
  • Oprea1_036404
  • TimTec1_000243
  • MetoclopraMide IMpurity C
  • 4-Amino-5-chloro-2-methoxybenzoic acid 97%
  • 340871_ALDRICH
  • Metoclopramide Impurity 3（Metoclopramide EP Impurity C）
  • Metoclopramide Impurity G
  • Metoclopramide Impurity D
  • Metoclopramide Impurity B
  • Metoclopramide EP Impurity C
  • 4-Amino-5-chloro-<i>o</i>-anisic Acid
  • LABOTEST-BB LT00012595
  • AURORA 22274
  • 4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACID
  • 4-AMINO-5-CHLORO-O-ANISIC ACID
  • 4-Amino-5-Chloro-2-Methoxyl Benzoic Acid
  • 4-Amino-5-Chloro-2-MethoxybenzoicAcid98%
  • 4-AMINO-5-CHLORO-3-METHOXYBENZOIC ACID
  • Metoclopramide BP Impurity C
  • TIMTEC-BB SBB003531
  • 4-Amino-5-chloro-o-anisic Acid &gt
  • 4-Amino-5-chloro-2-methoxybenzoic A
  • Clebopride EP Impurity A
  • 4-Amino-5-chloro-2-methoxybenzoic acid (Metoclopramide Impurity)
  • MetocloprCmide EP Impurity C
  • Metoclopramide Hydrochloride Monohydrate EP Impurity C
  • Ergothioneine Impurity 3
  • Metoclopramide Hydrochloride Monohydrate Impurity C
  • 4-Amino-5-Chloro-2-Methoxybenzoic Acid, 10 mM in DMSO
  • 7206-70-4
  • H2NC6H2ClOCH3CO2H
  • C8H8NO3Cl
  • Aromatic Amino Acids
  • Unnatural Amino Acid Derivatives
  • Specialty Synthesis
  • Peptide Synthesis
  • CARBOXYLIC ACID
  • Amines
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
  • Amines, Metabolites & Impurities, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
  • Pharmaceutical Intermediates
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
  • Organic acids