5-chloro-4-[(2Z)-2-[(3-hydroxyphenyl)methylidene]hydrazinyl]-1H-pyridazin-6-one

Product Name: 5-chloro-4-[(2Z)-2-[(3-hydroxyphenyl)methylidene]hydrazinyl]-1H-pyridazin-6-one
CAS No.: 92285-87-5
Chemical Name: 5-chloro-4-[(2Z)-2-[(3-hydroxyphenyl)methylidene]hydrazinyl]-1H-pyridazin-6-one
Synonyms: L82-G17;L82 G17,L82G17;4-Chloro-5-(2-(3-hydroxybenzylidene)hydrazinyl)pyridazin-3(2H)-one;3-Hydroxybenzaldehyde 2-(5-chloro-1,6-dihydro-6-oxo-4-pyridazinyl)hydrazone;Benzaldehyde, 3-hydroxy-, 2-(5-chloro-1,6-dihydro-6-oxo-4-pyridazinyl)hydrazone;5-chloro-4-[(2Z)-2-[(3-hydroxyphenyl)methylidene]hydrazinyl]-1H-pyridazin-6-one;4-Chloro-5-(2-((3-hydroxyphenyl)methylidene)hydrazin-1-yl)-2,3-dihydropyridazin-3-one
CBNumber: CB94369445
Molecular Formula: C11H9ClN4O2
Formula Weight: 264.67
MOL File: 92285-87-5.mol

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5-chloro-4-[(2Z)-2-[(3-hydroxyphenyl)methylidene]hydrazinyl]-1H-pyridazin-6-one Property

Density: 1.50±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:125.0(Max Conc. mg/mL);472.29(Max Conc. mM)
form: Solid
pka: 9.16±0.10(Predicted)
color: Pink to orange

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Hazard and Precautionary Statements (GHS)

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5-chloro-4-[(2Z)-2-[(3-hydroxyphenyl)methylidene]hydrazinyl]-1H-pyridazin-6-one Chemical Properties,Usage,Production

Description

L82-G17 is a selective uncompetitive inhibitor of DNA ligase I (LigI).

Uses

3-Hydroxy-benzaldehyde (5-Chloro-6-oxo-1,6-dihydro-pyridazin-4-yl)-hydrazone can be used to determine the structure-activity relationships among DNA ligase inhibitors.

in vitro

Among the LigI-selective inhibitors, L82-G17 exhibited increased activity against and selectivity for LigI compared with L82. Notably. L82-G17 is an uncompetitive inhibitor of the third step of the ligation reaction, phosphodiester bond formation. Cells expressing LigI were more sensitive to L82-G17 than isogenic LIG1 null cells._x000D_ _x000D_ Reference: DNA Repair (Amst). 2017 Dec;60:29-39. https://pubmed.ncbi.nlm.nih.gov/29078112/

target

L82-G17 is an uncompetitive DNA ligase I (Lig I)-selective inhibitor.

5-chloro-4-[(2Z)-2-[(3-hydroxyphenyl)methylidene]hydrazinyl]-1H-pyridazin-6-one Preparation Products And Raw materials

Raw materials

Preparation Products

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5-chloro-4-[(2Z)-2-[(3-hydroxyphenyl)methylidene]hydrazinyl]-1H-pyridazin-6-one Suppliers

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92285-87-5, 5-chloro-4-[(2Z)-2-[(3-hydroxyphenyl)methylidene]hydrazinyl]-1H-pyridazin-6-oneRelated Search:

5-chloro-4-[(2Z)-2-[(3-hydroxyphenyl)methylidene]hydrazinyl]-1H-pyridazin-6-one

L82-G17

L82 G17,L82G17

Benzaldehyde, 3-hydroxy-, 2-(5-chloro-1,6-dihydro-6-oxo-4-pyridazinyl)hydrazone

4-Chloro-5-(2-(3-hydroxybenzylidene)hydrazinyl)pyridazin-3(2H)-one

4-Chloro-5-(2-((3-hydroxyphenyl)methylidene)hydrazin-1-yl)-2,3-dihydropyridazin-3-one

3-Hydroxybenzaldehyde 2-(5-chloro-1,6-dihydro-6-oxo-4-pyridazinyl)hydrazone

92285-87-5