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DMT-dT Phosphoramidite

Product Name
DMT-dT Phosphoramidite
CAS No.
98796-51-1
Chemical Name
DMT-dT Phosphoramidite
Synonyms
DMT-dT-CE-Phosphoramidite;DMT-dT-CE;DMT-dT amidite;99%, ≤0.2%(K.F.);DMT-dT Pharmadite;DMT-dT-CE Amidites;DNAT-PHOSPHORAMIDITE;T-CE phosphoramidite;DT-CE PHOSPHORAMIDITE;2'-dT Phosphoramidite
CBNumber
CB9442232
Molecular Formula
C40H49N4O8P
Formula Weight
744.81
MOL File
98796-51-1.mol
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DMT-dT Phosphoramidite Property

Density 
1.22 at 20℃
vapor pressure 
0-0Pa at 20-50℃
storage temp. 
Sealed in dry,2-8°C
solubility 
soluble, clear
form 
powder or granules
pka
9.55±0.10(Predicted)
color 
white to off-white
biological source
non-animal source (no BSE/TSE risk)
Water Solubility 
soluble, clear
InChI
InChI=1/C40H49N4O8P/c1-27(2)44(28(3)4)53(50-23-11-22-41)52-35-24-37(43-25-29(5)38(45)42-39(43)46)51-36(35)26-49-40(30-12-9-8-10-13-30,31-14-18-33(47-6)19-15-31)32-16-20-34(48-7)21-17-32/h8-10,12-21,25,27-28,35-37H,11,23-24,26H2,1-7H3,(H,42,45,46)/t35-,36+,37+,53?/s3
InChIKey
UNOTXUFIWPRZJX-DJKSPSSYNA-N
SMILES
O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=C(C)C(=O)NC2=O)C[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,38,r|
LogP
5.8 at 20℃
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Safety

WGK Germany 
3
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T111040
Product name
DMT-dT Phosphoramidite
Purity
configured for MerMade
Packaging
6x8.20g
Price
$381
Updated
2025/07/31
Sigma-Aldrich
Product number
T111060
Product name
DMT-dT Phosphoramidite
Purity
configured for ABI
Packaging
12X3G
Price
$1250
Updated
2025/07/31
Sigma-Aldrich
Product number
T111040
Product name
DMT-dT Phosphoramidite
Purity
configured for MerMade
Packaging
6x16.8g
Price
$1550
Updated
2025/07/31
Sigma-Aldrich
Product number
T111000
Product name
DMT-dT Phosphoramidite
Purity
≥99% (31P-NMR)
Packaging
6x5g
Price
$512
Updated
2025/07/31
Sigma-Aldrich
Product number
T111000
Product name
DMT-dT Phosphoramidite
Packaging
186.2g
Price
$3180
Updated
2025/07/31
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DMT-dT Phosphoramidite Chemical Properties,Usage,Production

Uses

5''-O-[Bis(4-Methoxyphenyl)phenylmethyl]-thymidine 3''-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] is a nucleotide and reactant used in the solid-phase synthesis of phosphorothioate oligonucleotides, and in the synthesis of lipophilic 5''-phosphoramidate derivatives of DNA and RNA oligonucleotides.

Chemical Properties

5'-O-DMT-Thymidine-CE Phosphoramidite is also known as DMT-dT Phosphoramidite. The IUPAC Name of this compound is (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite. It allows for the introduction of thymidine units into oligonucleotides. Also, it has been used in various applications, including the synthesis of natural and unnatural DNA and RNA strands.

Synthesis

102691-36-1

40615-39-2

98796-51-1

General synthesis of (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuro-3-yl(2-cyanoethyl)diisopropyl phosphoramidite, starting with bis(diisopropylamino)(2-cyanoethoxy)phosphine and protecting thymidine The steps are as follows: with reference to Comparative Examples 1-3; three different phosphoramidite reactions (C1-C3) were carried out to react the protecting nucleoside reagent with 2-cyanoethyl-N,N,N',N'-tetraisopropylphosphoramidite in the presence of a pyridine-TFA activator and the yields were calculated for each of the reactions. The general procedure of Examples 12-18 was followed. Table 3 lists the different combinations of protected nucleosides, solvents and yields for the three reactions. As shown in Table 3, the yields of the present invention are surprisingly at least comparable, and in many cases superior, to similar reactions using conventional activators containing significantly less hindered unsubstituted pyridine salts.

References

[1] Chemical Communications, 1997, # 9, p. 877 - 878
[2] Tetrahedron Letters, 1990, vol. 31, # 10, p. 1463 - 1466
[3] Journal of the Chemical Society - Perkin Transactions 1, 1998, # 4, p. 747 - 757
[4] Patent: US2003/232980, 2003, A1. Location in patent: Page 7
[5] Patent: US2003/232980, 2003, A1. Location in patent: Page 6

DMT-dT Phosphoramidite Preparation Products And Raw materials

Raw materials

Preparation Products

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DMT-dT Phosphoramidite Suppliers

Canada 1 China 188 Germany 1 India 7 Switzerland 1 United Kingdom 2 United States 10 Global 210
Nugene Biopharm Science (Hangzhou) Co., Ltd.
Tel
13326014885
Email
service@nugene.com.cn
Country
China
ProdList
55
Advantage
58
Hongene Biotech Corporation
Tel
021-64757213
Fax
86-21-64700613
Email
info@hongene.com
Country
China
ProdList
672
Advantage
61
Nanjing Youwei Biotechnology Co., Ltd
Tel
025-86506605 13952030024
Fax
QQ：24810051
Email
13811988123@139.com
Country
China
ProdList
40
Advantage
58
Hefei Huana Biomedical Technology Co.,Ltd
Tel
17333066501
Email
shengwen.fang@huanaok.com.cn
Country
China
ProdList
95
Advantage
58
Wuhu Huaren Science and Technology Co., Ltd.
Tel
0553-5842013-801 18155347026
Fax
086-553-5843138
Email
jinhuaren@huarensh.com
Country
China
ProdList
255
Advantage
64
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
15883
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
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View Lastest Price from DMT-dT Phosphoramidite manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
5'-Dimethoxytrityl-3'-deoxythymidine 2'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite 98796-51-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-23
Hefei Huana Biomedical Technology Co.,Ltd.
Product
DMT-dT-CE 98796-51-1
Price
US $0.00/mg
Min. Order
100mg
Purity
≥99%
Supply Ability
20tons
Release date
2023-03-09
SHANGHAI NOVRIBO BIOTECH
Product
dT CE Phosphoramidite 98796-51-1
Price
US $100.00/kg
Min. Order
0.009999999776482582kg
Purity
99%
Supply Ability
5tons
Release date
2023-03-21

98796-51-1, DMT-dT PhosphoramiditeRelated Search:

Phenyltriethoxysilane Diphenyldimethoxysilane 2,3-Dimethylbutane Thymidine Diisopropyl ether N,N-Diisopropylethylamine 4-Methoxyphenylacetone Trimethoxypropylsilane 3-Aminopropyltriethoxysilane p-(2-Methoxyethyl) phenol FLUORESCEIN-DT CEP 5-ETHYNYL-DU CEP NPOM-CAGED-DT CEP BBQ-650-DT CEP DABCYL-DT CEP 2'-O-METHYL-5-METHYL-U CEP 5'-O-FDMT-THYMIDINE CEP 5-METHOXYMETHYL-DU CEP

  • 5'-O-DMT-thymidine 3'-CE phosphoramidite
  • DMT-dT PhosphoraMidite
  • 5'-O-[Bis(4-Methoxyphenyl)phenylMethyl]-thyMidine 3'-[2-cyanoethyl N,N-bis(1-Methylethyl)phosphoraMidite]
  • 5′-O-(4,4′-dimethoxytrityl)-2′-deoxythymidine-3′-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite]
  • 5'-O-DMT-2'-deoxythymidine-3'-CE Phosphoramidite
  • 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-5-methyluridine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite
  • 5'-O-(4,4'-Dimethoxytrityl)-thymidine-3'-cyanoethyl Phosphoramidite
  • 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYTHYMIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE
  • 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-thymidine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
  • 5'-O-(DIMETHOXYTRITYL)-THYMIDINE-3'-N,N-DIISOPROPYL(CYANOETHYL)PHOSPHORAMIDITE
  • 5'-dimethoxytrityl-3'-deoxythymidine 2'-[(2-cyanoethyl)-(n,n-diisopropyl)]-phosphoramidite
  • 5'-O-DMT- 2'-Deoxy Thymidine Phosphoramidite
  • Thymidine-3'-phosphoramidite
  • DMT-dT amidite
  • DMT-dT Pharmadite
  • DMT-DT AMIDITE 20G 6 PACK
  • DMT-DT AMIDITE 10G SINGLE
  • DMT-DT AMIDITE 2G 89 12 PACK
  • DMT-DT AMIDITE 4G 60ML VIAL 12 PACK
  • DMT-DT AMIDITE 1G AB 12 PACK
  • DMT-dT Amidite 6.85g, 6 Pack
  • DMT-DT AMIDITE 5G 6 PACK
  • DMT-DT AMIDITE 5G SINGLE
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  • DMT-THYMIDINE CED PHOSPHORAMIDITE
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  • DMT-DT AMIDITE 2G AB 12 PACK
  • DMT-DT AMIDITE 1G 89 12 PACK
  • 3'-O-P-5'-O-DMT-2'-DEOXY-THYRIDINE [DT PHOSPHORAMIDITE]
  • 5'-O-Dimethoxytrityl-2'-deoxy-thymidine-3'-O-(2-cyanoethyl)-Phosphoramidite
  • DMT-dT-CE-Phosphoramidite
  • DT-CE PHOSPHORAMIDITE
  • Thymidine, 5-O-bis(4-methoxyphenyl)phenylmethyl-, 3-2-cyanoethyl bis(1-methylethyl)phosphoramidite
  • DNAT-PHOSPHORAMIDITE
  • 5''-O-(4,4''-Dimethoxytrityl)-thymidine-3''-N,N-diisopropyl-(2-cyanoethyl)-pho
  • N-blocked-5'-O-DMT 3'-CED thymidine phosphoramidite
  • Deoxythymidine Phosphoramidite
  • (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite
  • REF DUPL: dT Phosphoramidite
  • 5'-O-(4,4'-Dimethoxytrityl)thymidine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite
  • thymidine-ce phosphoramidite for*biosearch 8000
  • Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
  • 5'-O-DMT-N2-isobutyryl-2'-de5'-O-DMT-Thymidine 3'-CE phosphoramidite
  • 5'-DMT-dT phosphoramidite
  • T-CE phosphoramidite
  • 3-[[(2R,3S,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
  • 5'-Dimethoxytrityl-2'-deoxyThymidine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • 5’-O-(4,4’-Dimethoxytrityl)thymidine-3’-O-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite,T-3’-phosphoramidite
  • 5'-O-DMT-dT-CE-Phosphoramidite
  • 5'-O-DMT-Thymidine-CE Phosphoramidite
  • DMT-dT-CE
  • 5'-O-DMT-Thymidine-3'-Cyanoethyl Phosphoramidite
  • deoxy Thymidine Amidite
  • DMT-dT-CE Amidites
  • 5’-O-(4, 4’-Dimethoxytrityl)thymidine-3’-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
  • 5'-O-Dimethoxytritylthymidine-3'-cyanoethyl-N,N-diisopropylphosphoramidite
  • DMTr-dT-3'-CE-Phosphoramidite
  • T Beta-Cyanoethyl Phosphoramidite (500 mg) (5'-O-Dimethoxytritylthymidine-3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite)