ChemicalBook > CAS DataBase List > FMOC-(4-AMINOMETHYL)-CYCLOHEXANE CARBOXYLIC ACID

FMOC-(4-AMINOMETHYL)-CYCLOHEXANE CARBOXYLIC ACID

Product Name: FMOC-(4-AMINOMETHYL)-CYCLOHEXANE CARBOXYLIC ACID
CAS No.: 188715-40-4
Chemical Name: FMOC-(4-AMINOMETHYL)-CYCLOHEXANE CARBOXYLIC ACID
Synonyms: FMOC-AMC-OH;FMOC-4-AMC-OH;Fmoc-4-Amc-OH(cis/trans mixture);Glutamic Acid Impurity 5 Monomer;FMOC-(4-AMINOMETHYL)-CYCLOHEXANE CARBOXYLIC ACID;4-[(Fmoc-amino)methyl]cyclohexanecarboxylic acid;4-(Fmoc-aminomethyl)cyclohexane-1-carboxylic acid;4-(Fmoc-aminomethyl)cyclohexane-1-carboxylicacid,98%;Fmoc-4-aminomethylcyclohexane carboxylic acid≥ 99% (HPLC);TRANS-4-(9-FLUORENYLMETHYLOXYCARBONYLAMINOMETHYL)-CYCLOHEXANOIC ACID
CBNumber: CB9446058
Molecular Formula: C23H25NO4
Formula Weight: 379.45
MOL File: 188715-40-4.mol

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FMOC-(4-AMINOMETHYL)-CYCLOHEXANE CARBOXYLIC ACID Property

Boiling point:: 604.9±28.0 °C(Predicted)
Density: 1.226±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
pka: 4.85±0.10(Predicted)
form: Powder
color: Off-white to white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: F620503
Product name: Fmoc-Amc-OH
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Usbiological

Product number: 278083
Product name: Fmoc-4-aminomethylcyclohexane carboxylic acid
Packaging: 1g
Price: $349
Updated: 2021/12/16

AK Scientific

Product number: 9831AA
Product name: 4-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)methyl)cyclohexanecarboxylicacid
Packaging: 1g
Price: $120
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM1047054
Product name: FMOC-(4-AMINOMETHYL)-CYCLOHEXANE CARBOXYLIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $502.81
Updated: 2021/12/16

Ambeed

Product number: A141531
Product name: Fmoc-4-Amc-OH
Purity: 95%
Packaging: 250mg
Price: $20
Updated: 2021/12/16

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FMOC-(4-AMINOMETHYL)-CYCLOHEXANE CARBOXYLIC ACID Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Synthesis

1197-17-7

28920-43-6

188715-40-4

Step 1: cis-4-(Aminomethyl)cyclohexyl-1-carboxylic acid (1.15 g, 7.30 mmol) was dissolved in 1,4-dioxane (12.0 mL) and 10% aqueous Na2CO3 (23.2 mL), followed by the addition of methyl 9-fluorenyl chloroformate (Fmoc-Cl, 2.26 g, 8.76 mmol). The reaction mixture was stirred at room temperature for 2.5 hours. After completion of the reaction, 1 M HCl (42.0 mL) was added to the mixture and extracted three times with ethyl acetate (EtOAc). The combined organic layers were washed sequentially with 1M HCl, water and brine. The aqueous layer was again extracted with EtOAc and all organic layers were combined and dried with anhydrous Na2SO4. The solvent was removed under reduced pressure to give the crude product. The crude product was washed with ice-cold EtOAc and dried under high vacuum to give N-Fmoc-4-aminomethylcyclohexanecarboxylic acid (2.28 g, 83% yield) as a white solid, which did not require further purification. [Ref: M. Nichifor; E. H. Schacht; Tetrahedron; 1994; 50; 12; 3747-3760].1H NMR (400 MHz, CDCl3): δ 0.87-1.02 (br.m, 2H), 1.34-1.52 (br.m, 4H), 1.81 (br. d, 2H, J = 6 Hz), 1.90-2.11 (br.s, 1H), 2.12-2.35 (br.m, 1H), 3.03 (Ψt, 2H, J = 6.2 Hz), 4.19 (br.Ψt, 1H, J = 6.5 Hz), 4.42 (br.Ψd, 2H, J = 6.5 Hz), 4.74 (br.s, 1H). 7.30 (Ψt, 2H, J = 7.4 Hz), 7.38 (Ψt, 2H, J = 7.4 Hz), 7.57 (d, 2H, J = 7.4 Hz), 7.75 (d, 2H, J = 7.4 Hz).

References

[1] Patent: EP1577289, 2005, A1. Location in patent: Page/Page column 23
[2] Organic Letters, 2008, vol. 10, # 10, p. 1881 - 1884

FMOC-(4-AMINOMETHYL)-CYCLOHEXANE CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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188715-40-4, FMOC-(4-AMINOMETHYL)-CYCLOHEXANE CARBOXYLIC ACIDRelated Search:

N-Fmoc-N'-Boc-L-2,3-Diaminopropionic acid FMOC-TIC-OH FMOC-ACPC-OH FMOC-SARCOSINE MONOHYDRATE Fmoc-1-aminomethyl-cyclohexane carboxylic acid

Fmoc-4-aminomethylcyclohexane carboxylic acid≥ 99% (HPLC)

4-(Fmoc-aminomethyl)cyclohexane-1-carboxylic acid

TRANS-4-(9-FLUOROENYLMETHYLOXYCARBONYLAMINOMETHYL)-CYCLOHEXANOIC ACID

NALPHA-9-Fluorenylmethoxycarbonyl-4-(aminomethyl)-cyclohexanecarboxylic aci

FMOC-4-AMC-OH

FMOC-(4-AMINOMETHYL)-CYCLOHEXANE CARBOXYLIC ACID

FMOC-AMC-OH

4-[(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-METHYL]-CYCLOHEXANECARBOXYLIC ACID

TRANS-4-(9-FLUORENYLMETHYLOXYCARBONYLAMINOMETHYL)-CYCLOHEXANOIC ACID

4-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexane-1-carboxylic acid

Cyclohexanecarboxylic acid, 4-[[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]methyl]-

4-(Fmoc-aminomethyl)cyclohexane-1-carboxylicacid,98%

Fmoc-4-Amc-OH(cis/trans mixture)

4-[(Fmoc-amino)methyl]cyclohexanecarboxylic acid

Glutamic Acid Impurity 5 Monomer

188715-40-4

Amino Acids