4-(4-Hydroxyphenyl)cyclohexanone
- Product Name
- 4-(4-Hydroxyphenyl)cyclohexanone
- CAS No.
- 105640-07-1
- Chemical Name
- 4-(4-Hydroxyphenyl)cyclohexanone
- Synonyms
- HOPCK;LABOTEST-BB LT00847424;4-(4-Oxocyclohexyl)phenol;4-(4-Hydroxyphenyl)cyclohexa;4-(P-Hydroxyphenyl)Cyclohexane;4-(P-HYDROXYPHENYL)CYCLOHEXANONE;4-(4-HYDROXYPHENYL)CYCLOHEXANONE;4-(4'-Hydroxyphenyl)cyclohexanone;4-(4'-HYDROXYPHENYL)-CYCLOHEXANONE;Cyclohexanone,4-(4-hydroxyphenyl)-
- CBNumber
- CB9448209
- Molecular Formula
- C12H14O2
- Formula Weight
- 190.24
- MOL File
- 105640-07-1.mol
4-(4-Hydroxyphenyl)cyclohexanone Property
- Melting point:
- 170-175 °C
- Boiling point:
- 357.2±42.0 °C(Predicted)
- Density
- 1.149±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- powder to crystal
- pka
- 10.10±0.30(Predicted)
- color
- White to Almost white
- BRN
- 3269332
- InChI
- InChI=1S/C12H14O2/c13-11-5-1-9(2-6-11)10-3-7-12(14)8-4-10/h1-2,5-6,10,13H,3-4,7-8H2
- InChIKey
- SLJYPZJZQIHNGU-UHFFFAOYSA-N
- SMILES
- C1(=O)CCC(C2=CC=C(O)C=C2)CC1
- CAS DataBase Reference
- 105640-07-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 56117
- Product name
- 4-(4-Hydroxyphenyl)cyclohexanone
- Purity
- ≥97.0% (HPLC)
- Packaging
- 25g
- Price
- $93.5
- Updated
- 2025/07/31
- Product number
- H1316
- Product name
- 4-(4-Hydroxyphenyl)cyclohexanone
- Purity
- >95.0%(GC)
- Packaging
- 5g
- Price
- $29
- Updated
- 2025/07/31
- Product number
- H1316
- Product name
- 4-(4-Hydroxyphenyl)cyclohexanone
- Purity
- >95.0%(GC)
- Packaging
- 25g
- Price
- $81
- Updated
- 2025/07/31
- Product number
- H973025
- Product name
- 4-(4-Hydroxyphenyl)cyclohexanone
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- P839
- Product name
- 4-(4-Hydroxyphenyl)cyclohexanone
- Packaging
- 5g
- Price
- $27
- Updated
- 2021/12/16
4-(4-Hydroxyphenyl)cyclohexanone Chemical Properties,Usage,Production
Chemical Properties
White crystalline powder
Synthesis
82240-03-7
105640-07-1
General procedure: 56.1 g of 4-(4-benzyloxyphenyl)cyclohexanone, 336.6 mL of tetrahydrofuran and 2.8 g of 5% Pd/C catalyst were sequentially added to a 500 mL three-neck flask. The atmosphere in the flask was replaced three times with hydrogen and the hydrogenation reaction was subsequently carried out under hydrogen atmosphere. The reaction system was heated to 40-45 °C in a water bath and maintained at this temperature until completion of the reaction (reaction endpoint determination criterion: 4-(4-benzyloxyphenyl)cyclohexanone residue less than 1%, specifically 0.5687%). Upon completion of the reaction, the heating and hydrogen supply were stopped. Post-treatment steps: the reaction mixture was filtered and the filter cake was washed twice with tetrahydrofuran, 5 mL each time. the filtrates were combined and concentrated under reduced pressure at 35-45 °C and -0.08 MPa to -0.09 MPa until no fraction flowed out, yielding a white solid. To this solid was added 195 mL of ethanol and heated to reflux (60-65 °C) for 1-2 h until completely dissolved and clarified. The solution was then cooled to -25 to -15°C and left to crystallize for 8 hours. The crystals were collected by filtration and washed twice with ethanol, 5 mL each time.The filter cake was dried under reduced pressure at 45-55 °C, -0.08 MPa to -0.09 MPa for 10 h to give 32 g of white to off-white powdery solid, i.e., the target product 4-(4-hydroxyphenyl)cyclohexanone.
References
[1] Patent: CN106892805, 2017, A. Location in patent: Paragraph 0034; 0035; 0036
4-(4-Hydroxyphenyl)cyclohexanone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(4-Hydroxyphenyl)cyclohexanone manufacturers
- Product
- 4-(4-Hydroxyphenyl)cyclohexanone 105640-07-1
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-11
- Product
- 4-(4-Hydroxyphenyl)cyclohexanone 105640-07-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-29
- Product
- 4-(4-Hydroxyphenyl)cyclohexanone 105640-07-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-14