ChemicalBook > CAS DataBase List > Tibolone

Tibolone

Product Name
Tibolone
CAS No.
5630-53-5
Chemical Name
Tibolone
Synonyms
LIVIAL;Tiblone;LIVIELLA;TIBOLONE;Tiboione;tibolona;Org OD 14;tibolonum;Tibolone(EP);Tibolone IMpurity
CBNumber
CB9453050
Molecular Formula
C21H28O2
Formula Weight
312.45
MOL File
5630-53-5.mol
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Tibolone Property

Melting point:
169 °C
Boiling point:
447.4±45.0 °C(Predicted)
Density 
1.13±0.1 g/cm3(Predicted)
refractive index 
105 ° (C=0.54, CH2Cl2/Et2O)
storage temp. 
2-8°C
solubility 
DMSO: soluble15mg/mL, clear
pka
13.10±0.60(Predicted)
color 
white to beige
Merck 
9427
InChI
InChI=1/C21H28O2/c1-4-21(23)10-8-18-19-13(2)11-14-12-15(22)5-6-16(14)17(19)7-9-20(18,21)3/h1,13,17-19,23H,5-12H2,2-3H3/t13-,17-,18+,19-,20+,21+/s3
InChIKey
WZDGZWOAQTVYBX-PGFZCDQENA-N
SMILES
[C@@]12([H])[C@H](C)CC3CC(=O)CCC=3[C@@]1([H])CC[C@]1(C)[C@](CC[C@@]21[H])(O)C#C |&1:0,2,12,16,18,21,r|
CAS DataBase Reference
5630-53-5(CAS DataBase Reference)
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Safety

Hazard Codes 
N
Risk Statements 
51/53
Safety Statements 
22-24/25-61
RIDADR 
UN 3077 9/PG 3
RTECS 
RC8964020
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0000668
Product name
Tibolone for system suitability
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0000668
Price
$153
Updated
2024/03/01
Cayman Chemical
Product number
10006321
Product name
Tibolone
Purity
≥98%
Packaging
100mg
Price
$34
Updated
2024/03/01
Cayman Chemical
Product number
10006321
Product name
Tibolone
Purity
≥98%
Packaging
250 mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
10006321
Product name
Tibolone
Purity
≥98%
Packaging
500mg
Price
$152
Updated
2024/03/01
Cayman Chemical
Product number
10006321
Product name
Tibolone
Purity
≥98%
Packaging
1 g
Price
$287
Updated
2024/03/01
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Tibolone Chemical Properties,Usage,Production

Description

Tibolone is a synthetic steroid with weak progestational and estrogenic properties, reportedly useful in controlling symptoms resulting from natural or surgical menopause. It has thus far shown no significant antithrombotic effect in post-menopausal patients.

Chemical Properties

White Solid

Originator

Akzo (Organon) (The Netherklands)

Uses

A synthetic steroid with weak estrogenic, androgenic and progestogenic activity. A pharamceutical used in the treatment of menopausal syndrome

Definition

ChEBI: Estran-3-one with a double bond between positions 5 and 10, and bearing both an ethynyl group and a hydroxy group at position 17 (R-configuration). A synthetic steroid hormone drug which acts as an agonist at all five type I steroid hormon receptors, it is used in the prevention of postmenopausal osteoporosis and for treatment of endometriosis.

brand name

Livial

Pharmacokinetics

Raloxifene is rapidly absorbed following oral administration, with an estimated 60% absorption, but it has a very low bioavailability (2%), associated with extensive phase II metabolism. The metabolites are excreted via the bile, with potential enterohepatic recycling that could account for the interaction with cholestyramine. Supportive of the enterohepatic recycling is the half-life of 28 hours. Metabolism of raloxifene occurs to a great extent in the intestine and consists of glucuronide conjugation catalyzed by uridine diphosphate glucuronosyltransferase (UGT).

Clinical Use

Tibolone is a synthetic steroid that has been shown to increase bone mineral density similar to alendronate. The U.S. FDA approval is pending; overseas, this agent is used for the treatment of menopausal symptoms as well as the prevention of osteoporosis. It is considered to be a viable alternative to conjugated equine estrogen plus micronized progesterone.

Side effects

The most common reason for patient withdrawal from clinical trials was vaginal bleeding (also a common side effect when estrogen therapy is used).

Tibolone Preparation Products And Raw materials

Raw materials

Preparation Products

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Tibolone Suppliers

Canada 1 China 147 India 10 Italy 2 Malaysia 1 Switzerland 1 The Netherlands 1 United Kingdom 6 United States 14 Global 183
Shanghai Boyle Chemical Co., Ltd.
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Beijing HuaMeiHuLiBiological Chemical
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NCE Biomedical Co.,Ltd.
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View Lastest Price from Tibolone manufacturers

Wuhan Xinhao Biotechnology Co., Ltd
Product
Tibolone 5630-53-5
Price
US $10.00-100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100 tons
Release date
2024-01-18
Nantong Guangyuan Chemicl Co,Ltd
Product
Tibolone 5630-53-5
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2023-11-01
Nantong Guangyuan Chemicl Co,Ltd
Product
Tibolone 5630-53-5
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2023-12-07

5630-53-5, TiboloneRelated Search:

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  • TIBOLONE
  • LIVIELLA
  • LIVIAL
  • 5(10)-ESTREN-7-ALPHA-METHYL-17-ALPHA-ETHYNYL-17-BETA-OL-3-ONE
  • (7A,17A)-17-HYDROXY-7-METHYL-19-NORPREGN-5(10)-EN-20-YL-3-ONE
  • 17-hydroxy-7alpha-methyl-19-norpregn-5(10)-en-20-yn-3-one
  • 17ALPHA-HYDROXY-7ALPHA-METHYL-19-NORPREGN-5(10)-EN-20-YN-3-ONE
  • 19-NORPREGN-5(10)-EN-20-YN-3-ONE,17-HYDROXY-7-METHYL-, (7A,17A)-
  • 17β-Hydroxy-7α-methyl-19-nor-17α-pregn-5(10)-ene-20-yn-3-one
  • (7a,17a)-17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one
  • 7a-Methyl-17a-ethynyl-17-hydroxy-5(10)-estren-3-one
  • 7a-Methyl-5,10-norethindrone
  • Org OD 14
  • (7α,17α)-17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one
  • 19-Norpregn-5(10)-en-20-yn-3-one, 17-hydroxy-7-methyl-, (7alpha,17alpha)-
  • 7a-Methyl-17a-ethynyl-17b-hydroxy-5(10)-estren-3-one
  • 7a-Methyl-D5,10-norethindrone
  • Tibolone 17-Hydroxy-7alpha-methyl-19-norpregn-5(10)-en-20-yn-3-one
  • 17-Hydroxy-7α-methyl-19-nor-17α-pregn-5(10)-en-20-yn-3-one
  • 5(10)-Estren-7α-methyl-17α- ethynyl-17β- ol-3-one
  • Tiboione
  • Tibolone(EP)
  • 7α-Methyl-17α-ethynyl-17β-hydroxy-5(10)-estren-3-one
  • 7α-Methyl-5,10-norethindrone
  • (7R,13S,17R)-17-ethynyl-17-hydroxy-7,13-dimethyl-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
  • (7R,9S,13S,14S,17R)-17-ethynyl-17-hydroxy-7,13-dimethyl-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
  • Tiblone
  • Tibolone for system suitability CRS
  • tibolona
  • tibolonum
  • 19-Norpregn-5(10)-en-20-yn-3-one, 17-hydroxy-7-methyl-, (7α,17α)-
  • (7R,8R,9S,13S,14S,17R)-17-ethynyl-17-hydroxy-7,13-dimethyl-4,6,7,8,9,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
  • Tibolone USP/EP/BP
  • Tibolone D5Q: What is Tibolone D5 Q: What is the CAS Number of Tibolone D5 Q: What is the storage condition of Tibolone D5 Q: What are the applications of Tibolone D5
  • TiboloneQ: What is Tibolone Q: What is the CAS Number of Tibolone Q: What is the storage condition of Tibolone Q: What are the applications of Tibolone
  • 5(10)-ESTREN-7α-METHYL-17α- ETHYNYL-17β- OL-3-ONE
  • Tibolone IMpurity
  • Tibolone (Liviella) (Livial)
  • 5630-53-5
  • 5630-53-6
  • Steroid and Hormone
  • Active Pharmaceutical Ingredients
  • Hormone
  • Acetylenes
  • Biochemistry
  • Functionalized Acetylenes
  • Hydroxyketosteroids
  • Steroids
  • Intermediates & Fine Chemicals
  • Pharmaceuticals