BRYOSTATIN 1
- Product Name
- BRYOSTATIN 1
- CAS No.
- 83314-01-6
- Chemical Name
- BRYOSTATIN 1
- Synonyms
- BRYO 1;CS-1164;NSC-339555;BRYOSTATIN;Byrostatin 1;BRYOSTATIN 1;bryostatin1,0;(26R)-Bryostatin 1;Bryostatin 1 - CAS 83314-01-6 - Calbiochem;(1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-Methoxy-2-oxoethylidene)-10,10,26,26-tetraMethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-y
- CBNumber
- CB9454936
- Molecular Formula
- C47H68O17
- Formula Weight
- 905.03
- MOL File
- 83314-01-6.mol
BRYOSTATIN 1 Property
- Melting point:
- 230-235°
- alpha
- D25 +34.1° (c = 0.044 in methanol)
- Boiling point:
- 716.44°C (rough estimate)
- Density
- 1.1245 (rough estimate)
- refractive index
- 1.5940 (estimate)
- storage temp.
- -20°C
- solubility
- DMSO: soluble
- form
- solid
- pka
- 11.10±0.70(Predicted)
- color
- white
Safety
- Hazard Codes
- Xn
- Risk Statements
- 68
- Safety Statements
- 22-24/25-36/37
- WGK Germany
- 3
- RTECS
- EH9455000
- HS Code
- 2932990090
- Toxicity
- LD50 in mice, rats (mg/kg): 0.038, 0.068 i.v. (Prendiville)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
N-Bromosuccinimide Price
- Product number
- B7431
- Product name
- Bryostatin 1
- Purity
- ≥99%, solid
- Packaging
- 10μg
- Price
- $228
- Updated
- 2024/03/01
- Product number
- 203811
- Product name
- Bryostatin 1 - CAS 83314-01-6 - Calbiochem
- Purity
- A macrocyclic lactone with antitumor properties.
- Packaging
- 10μG
- Price
- $246
- Updated
- 2024/03/01
- Product number
- 2383
- Product name
- Bryostatin 1
- Purity
- ≥98%(HPLC)
- Packaging
- 10U
- Price
- $187
- Updated
- 2021/12/16
- Product number
- 254820
- Product name
- Bryostatin 1
- Packaging
- 10ug
- Price
- $432
- Updated
- 2021/12/16
- Product number
- CS-0025440
- Product name
- Bryostatin 1
- Packaging
- 10ug
- Price
- $480
- Updated
- 2021/12/16
BRYOSTATIN 1 Chemical Properties,Usage,Production
Uses
Bryostatin 1 has been used to study its effects on spontaneous Crohn′s disease (CD) like colitis in?mice. It has also been used to study its effects as an anthelmintic drug on adult Syphacia muris infection in rats.
Definition
ChEBI: A member of the class of bryostatins that is (17E)-2-oxooxacyclohexacos-17-ene which is substituted by hydroxy groups at positions 4, 10, and 20; an acetoxy group at position 8; methyl groups at positions 9, 9, 18, and 19; 2-methoxy-2-oxoe hylidene groups at positions 14 and 24; an (E,E)-octa-2,4-dienoyloxy group at position 21; and with oxygen bridges linking positions 6 to 10, 12 to 16, and 20 to 24. It is one of the most abundant member of the class of br ostatins.
Biological Activity
Protein kinase C (PKC) activator that binds with high affinity (K i = 1.35 nM). Initially activates and subsequently induces downregulation of PKC isozymes. Sensitizes tumor cells to cytotoxic effects of anticancer agents.
Biochem/physiol Actions
Bryostatin 1 (Bry1) is a macrocyclic lactone. This synaptogenic compound is obtained from the marine bryozoan?Bugula neritina. Bry1 is capable of reversing synaptic loss. It can enable synaptic maturation in animal models with several neurological disorders. It possesses antidepressant activity, when administered intracebroventricularly. Bry1 is known to participate in protecting cell tight junctions (TJs), anti-inflammatory functions and immune regulation.
storage
Store at -20°C
References
[1]. gschwendt m, fürstenberger g, rose-john s, et al. bryostatin 1, an activator of protein kinase c, mimics as well as inhibits biological effects of the phorbol ester tpa in vivo and in vitro. carcinogenesis, 1988, 9(4): 555-562.
[2]. stone rm, sariban e, pettit gr, et al. bryostatin 1 activates protein kinase c and induces monocytic differentiation of hl-60 cells. blood, 1988, 72(1): 208-213.
[3]. schuchter lm, esa ah, may s, et al. successful treatment of murine melanoma with bryostatin 1. cancer res, 1991, 51(2): 682-687.
BRYOSTATIN 1 Preparation Products And Raw materials
Raw materials
Preparation Products
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