ALPHA-APO-OXYTETRACYCLINE

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ALPHA-APO-OXYTETRACYCLINE

Product Name: ALPHA-APO-OXYTETRACYCLINE
CAS No.: 18751-99-0
Chemical Name: ALPHA-APO-OXYTETRACYCLINE
Synonyms: β-Apooxytetracycline;b-Apo-oxytetracycline;β-Apo-oxytetracycline;BETA-APO-OXYTETRACYCLINE;Apooxytetracycline, beta-;ALPHA-APO-OXYTETRACYCLINE;Oxytetracycline Impurity E;β-Apo-oxytetracycline, >85%;Oxytetracycline EP Impurity E;β-Apo-oxytetracycline, EvoPure?
CBNumber: CB9455892
Molecular Formula: C22H22N2O8
Formula Weight: 442.42
MOL File: 18751-99-0.mol

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ALPHA-APO-OXYTETRACYCLINE Property

Melting point:: 200-204 °C
Boiling point:: 742.4±60.0 °C(Predicted)
Density: 1.62±0.1 g/cm3(Predicted)
storage temp.: Refrigerator, Under Inert Atmosphere
solubility: Aqueous Base (Slightly), Methanol (Slightly, Heated, Sonicated)
form: Powder
pka: 1.62±0.58(Predicted)
color: Yellow-brown to brown
Stability:: Unstable in basic solution
EPA Substance Registry System: 1-Cyclohexene-1-carboxamide, 4-(1,3-dihydro-4,5-dihydroxy-9-methyl-3-oxonaphtho[2,3-c]furan-1-yl)-3-(dimethylamino)-2,5-dihydroxy-6-oxo- (18751-99-0)

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Safety

Hazard Codes: Xn
Risk Statements: 63
Safety Statements: 45-36/37
HS Code: 29413020

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H361Suspected of damaging fertility or the unborn child

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P314Get medical advice/attention if you feel unwell.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27099
Product name: β-Apooxytetracycline
Packaging: 1mg
Price: $76
Updated: 2024/03/01

Cayman Chemical

Product number: 27099
Product name: β-Apooxytetracycline
Packaging: 10mg
Price: $583
Updated: 2024/03/01

Cayman Chemical

Product number: 27099
Product name: β-Apooxytetracycline
Packaging: 500μg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 27099
Product name: β-Apooxytetracycline
Packaging: 5mg
Price: $312
Updated: 2024/03/01

Usbiological

Product number: 002804
Product name: β-Apo-oxytetracycline
Packaging: 1mg
Price: $340
Updated: 2021/12/16

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ALPHA-APO-OXYTETRACYCLINE Chemical Properties,Usage,Production

Description

β-Apooxytetracycline is a potential impurity found in commercial preparations of oxytetracycline. β-Apooxytetracycline is a degradation product formed from oxytetracycline via acid hydrolysis. It has a relative potency of 0.1 compared with oxytetracycline for inhibiting the growth of aerobic sludge bacteria, an MIC₅₀ value of 32 mg/L for tetracycline-sensitive strains of Pseudomonas, and MIC₅₀ values of greater than 32 mg/L for tetracycline-sensitive strains of Agrobacterium, Moraxella, and Bacillus, as well as tetracycline-resistant strains of E. coli. β-Apooxytetracycline (10 mg/kg) is toxic to rats, decreasing body weight, disrupting blood cell counts, and inducing hepatocyte necrosis.

Chemical Properties

yellow-brown to brown powder

Uses

Oxytetracycline metabolite (absolute stereochemistry unknown)

Uses

β-Apooxytetracycline is a degradation product of oxytetracycline formed under acidic conditions. An initial dehydration to anhydrooxytetracycline then undergoes an internal cyclisation of the C5-OH to the C12 ketone. The resulting cleavage of the C12-C12a bond generates two isomers, α- and β-apooxytetracycline. β-apooxytetracycline is an important standard for monitoring oxytetracycline stability.

Uses

β-Apooxytetracycline is a degradation product of oxytetracycline formed under acidic conditions. After initial dehydration to anhydrooxytetracycline, it undergoes an internal cyclisation of the C5-OH to the C12 ketone. The resulting cleavage of the C12-C12a bond generates two isomers, α- and β-apooxytetracycline. β-Apooxytetracycline is an important standard for monitoring oxytetracycline stability.

ALPHA-APO-OXYTETRACYCLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ALPHA-APO-OXYTETRACYCLINE manufacturers

Career Henan Chemical Co

Product: ALPHA-APO-OXYTETRACYCLINE 18751-99-0
Price: US $1.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2019-12-25

18751-99-0, ALPHA-APO-OXYTETRACYCLINERelated Search:

ALPHA-APO-OXYTETRACYCLINE,alpha-Apo-oxytetracycline, 'can be used as secondary standard' (4S,4aR,5R,12aS)-4-(dimethylamino)-3,5,10,11,12a-pentahydroxy-6-methyl-1,12-dioxo-1,4,4a,5,12,12a-hexahydrotetracene-2-carboxamide Tetracycline 4-Epioxytetracycline 2-acetyl-2-decarboxamidooxytetracycline Oxytetracycline

BETA-APO-OXYTETRACYCLINE

ALPHA-APO-OXYTETRACYCLINE

β-Apo-oxytetracycline

b-Apo-oxytetracycline

Apooxytetracycline, beta-

beta-Apo-oxytetracycline, 'can be used as secondary standard'

Oxytetracycline EP Impurity E

Oxytetracycline EP Impurity E/β-Apo-Oxytetracycline

Oxytetracycline Impurity E

Oxytetracycline Impurity 5（Oxytetracycline EP Impurity E）

1-Cyclohexene-1-carboxamide, 4-[(3R)-1,3-dihydro-4,5-dihydroxy-9-methyl-3-oxonaphtho[2,3-c]furan-1-yl]-3-(dimethylamino)-2,5-dihydroxy-6-oxo-, (3S,4S,5R)-

β-Apooxytetracycline

(3S)-4t-[(R)-4,5-dihydroxy-9-methyl-3-oxo-1,3-dihydro-naphtho[2,3-c]furan-1-yl)-3r-dimethylamino-2,5ξ-dihydroxy-6-oxo-cyclohex-1-enecarboxylicacidamide

ALPHA-APO-OXYTETRACYCLINE USP/EP/BP

β-Apo-oxytetracycline, >85%

β-Apo-oxytetracyclineQ: What is β-Apo-oxytetracycline Q: What is the CAS Number of β-Apo-oxytetracycline Q: What is the storage condition of β-Apo-oxytetracycline

(5S)-4-[(1S)-4,5-dihydroxy-9-methyl-3-oxo-1H-benzo[f][2]benzofuran-1-yl]-3-(dimethylamino)-2,5-dihydroxy-6-oxocyclohexene-1-carboxamide

β-Apo-oxytetracycline, EvoPure?

Oxytetracycline EP Impurity E (beta-Apo-Oxytetracycline)

18751-99-0

Intermediates & Fine Chemicals

Metabolites & Impurities

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