D-Tryptophan methyl ester hydrochloride
- Product Name
- D-Tryptophan methyl ester hydrochloride
- CAS No.
- 14907-27-8
- Chemical Name
- D-Tryptophan methyl ester hydrochloride
- Synonyms
- D-TRYPTOPHAN METHYL ESTER HCL;Methyl D-Tryptophanate Hydrochloride;Trp-OMe;D-TRYPTOPHAN METHYL ESTER;ANAM-002;D-TRP.OME.HCL;D-Trp-OCH3.Hcl;H-D-TRP-OME·HCL;H-D-TRP-OME HCL;D-Tryptophan methyl
- CBNumber
- CB9459476
- Molecular Formula
- C12H15ClN2O2
- Formula Weight
- 254.71
- MOL File
- 14907-27-8.mol
D-Tryptophan methyl ester hydrochloride Property
- Melting point:
- 213-216 °C(lit.)
- Density
- 1.337g/cm3 at 20℃
- refractive index
- -19 ° (C=5, MeOH)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO, (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Off-White
- optical activity
- [α]20/D 18°, c = 5 in methanol
- Water Solubility
- Soluble in water (150 mg/ml), dimethyl sulfoxide and methanol (50 mg/ml).
- InChI
- InChI=1/C12H14N2O2.ClH/c1-16-12(15)10(13)6-8-7-14-11-5-3-2-4-9(8)11;/h2-5,7,10,14H,6,13H2,1H3;1H/t10-;/s3
- InChIKey
- XNFNGGQRDXFYMM-MEQOOBBNNA-N
- SMILES
- C12C=CC=CC=1NC=C2C[C@@H](N)C(=O)OC.Cl |&1:10,r|
- LogP
- 1.089
- CAS DataBase Reference
- 14907-27-8(CAS DataBase Reference)
Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- PH017490
- Product name
- Methyl (2R)-2-amino-3-(1H-indol-3-yl)propanoate
- Purity
- AldrichCPR
- Packaging
- 1g
- Price
- $81.6
- Updated
- 2023/06/20
- Product number
- 364509
- Product name
- D-Tryptophan methyl ester hydrochloride
- Purity
- 98%
- Packaging
- 5g
- Price
- $42.1
- Updated
- 2022/05/15
- Product number
- T2442
- Product name
- D-Tryptophan Methyl Ester Hydrochloride
- Purity
- >98.0%(N)
- Packaging
- 5g
- Price
- $25
- Updated
- 2024/03/01
- Product number
- T2442
- Product name
- D-Tryptophan Methyl Ester Hydrochloride
- Purity
- >98.0%(N)
- Packaging
- 25g
- Price
- $100
- Updated
- 2024/03/01
- Product number
- H60622
- Product name
- D-Tryptophan methyl ester hydrochloride, 98%
- Packaging
- 5g
- Price
- $79.5
- Updated
- 2024/03/01
D-Tryptophan methyl ester hydrochloride Chemical Properties,Usage,Production
Chemical Properties
Off-White Crystalline Solid
Uses
Intermediate for the synthesis of Tryptophan derivatives.
Uses
D-Tryptophan Methyl Ester Hydrochloride is an intermediate in the synthesis of Tryptophan derivatives.
Application
The Pictet–Spengler reaction of D-Tryptophan methyl ester hydrochloride with piperonal in various solvents has been extensively studied, the solvent-dependence of stereoselectivities could be principally attributed to the solubility difference between cis and trans products 5-HCl in the used solvent, the best stereoselectivity (cis/trans = 99:1) was obtained using nitromethane or acetonitrile as the solvent. Cialis, 12a-epi-Cialis, deuterium-labeled, 3,3,12a-d3-Cialis, and 3,3,12a-d3-12a-epi-Cialis could be efficiently synthesized from D-Tryptophan methyl ester hydrochloride[1].
Synthesis
D-tryptophan and methyl sulfonate are reacted in a solvent at 25 to 100°C to generate D-tryptophan methyl ester sulfonate. Dissolve the obtained D-tryptophan methyl ester sulfonate in water and adjust the pH to alkaline with alkali to convert it into D-tryptophan methyl ester. After the reaction, extract with an organic solvent, add a desiccant for dehydration, and obtain an extract containing D-tryptophan methyl ester. Finally, dry hydrogen chloride gas is passed into the obtained extract containing D-tryptophan methyl ester for reaction to obtain D-tryptophan methyl ester hydrochloride.
References
[1] Xiao-Xin Shi. “Highly stereoselective Pictet–Spengler reaction of d-tryptophan methyl ester with piperonal: convenient syntheses of Cialis (Tadalafil), 12a-epi-Cialis, and their deuterated analogues.” Tetrahedron, asymmetry 19 4 (2008): Pages 435-442.
D-Tryptophan methyl ester hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
D-Tryptophan methyl ester hydrochloride Suppliers
- Tel
- 021-54306202 13764082696;
- info@hanhongsci.com
- Country
- China
- ProdList
- 42982
- Advantage
- 64
- Tel
- 400-8464006 15805183379
- Fax
- 86-025-58905816
- zjp@redwood.com.cn
- Country
- China
- ProdList
- 645
- Advantage
- 60
- Tel
- 051389158300 18014392889
- Fax
- 0513-89158198
- sales8@puyerbiopharma.com
- Country
- China
- ProdList
- 4316
- Advantage
- 58
- Tel
- 0838-2809458 13350585791
- Fax
- +86-838-2274207
- pharm@biots.cn
- Country
- China
- ProdList
- 348
- Advantage
- 66
- Tel
- 021-60345187 13671753212
- Fax
- 021-34702061
- lzz841106@aliyun.com
- Country
- China
- ProdList
- 10287
- Advantage
- 55
- Tel
- 13053322091 13053322091
- admin@mopaikeji.com
- Country
- China
- ProdList
- 10972
- Advantage
- 58
- Tel
- 199-4188-3835 19941883835
- 746524151@qq.com
- Country
- China
- ProdList
- 53
- Advantage
- 58
- Tel
- 0531-58595315 13864187945
- 415834789@qq.com
- Country
- China
- ProdList
- 94
- Advantage
- 58
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-61259108 18621169097
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40241
- Advantage
- 62
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15848
- Advantage
- 69
- Tel
- 400-0066400 13621662912
- Fax
- 021-55660885
- sales@jonln.com
- Country
- China
- ProdList
- 1998
- Advantage
- 65
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30132
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24539
- Advantage
- 81
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44751
- Advantage
- 61
- Tel
- 21-61263452 13641803416
- Fax
- 86-21-61263399
- ymbetter@glbiochem.com
- Country
- China
- ProdList
- 9981
- Advantage
- 64
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- sales@capotchem.com
- Country
- China
- ProdList
- 18217
- Advantage
- 66
- Tel
- 010-82967028 13552068683
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12458
- Advantage
- 60
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9984
- Advantage
- 60
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9551
- Advantage
- 66
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- zhangsn@titansci.com
- Country
- China
- ProdList
- 14113
- Advantage
- 59
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11660
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32344
- Advantage
- 50
- Tel
- 13355009207 13355009207
- Fax
- 0539-6365991
- 3007715519@qq.com
- Country
- China
- ProdList
- 18739
- Advantage
- 57
- Tel
- 021-50460086-9 15921403865
- Fax
- +86-21-50462321
- han_yajun@dctc.daicel.com
- Country
- China
- ProdList
- 6854
- Advantage
- 65
- Tel
- 0531-58897003 15550412551
- Fax
- 0531-58897003
- market@jnchsd.com
- Country
- China
- ProdList
- 213
- Advantage
- 62
- Tel
- 400-1166-196 18981987031
- Fax
- 028-84555506 800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 11726
- Advantage
- 57
- Tel
- 400 638 7771
- sales@heowns.com
- Country
- China
- ProdList
- 14443
- Advantage
- 57
- Tel
- 0370-2785118 15343847665
- Fax
- QQ:3470079902
- huawenchem@163.com
- Country
- China
- ProdList
- 3205
- Advantage
- 55
- Tel
- 028-82550498 19102685862
- Fax
- 086-28-82550468
- sales@pu-kang.com
- Country
- China
- ProdList
- 485
- Advantage
- 58
- Tel
- 0871-65217109 13211707573;
- Fax
- 0871-65215563
- y.liu@mail.biobiopha.com
- Country
- China
- ProdList
- 5654
- Advantage
- 65
- Tel
- 4008-755-333 18080918076
- Fax
- 028-86757656
- 800078821@qq.com
- Country
- China
- ProdList
- 9725
- Advantage
- 55
- Tel
- 021-61551611 13296011611
- Fax
- +86 21-50676805
- contact@trustwe.com
- Country
- China
- ProdList
- 9900
- Advantage
- 58
- Tel
- 0755-4000505016 13380397412
- Fax
- 0755 28094224
- 3001272453@qq.com
- Country
- China
- ProdList
- 4972
- Advantage
- 50
- Tel
- 022-60116533 13207668525
- Fax
- 022-60979672
- saleskc@scipharmacn.com
- Country
- China
- ProdList
- 875
- Advantage
- 58
- Tel
- 86-21-34053660
- Fax
- 86-21-34053661
- sale@labgogo.com
- Country
- China
- ProdList
- 9872
- Advantage
- 52
- Tel
- 010-56645598 13366904824
- Fax
- 01062230033
- bjkaida@163.com
- Country
- China
- ProdList
- 1664
- Advantage
- 59
- Tel
- 010-56205725
- Fax
- 010-65763397
- waley188@sohu.com
- Country
- China
- ProdList
- 12338
- Advantage
- 58
- Tel
- 18017383231 18017383231
- Fax
- qq:2817624287
- lyh_antaeus@163.com
- Country
- China
- ProdList
- 9352
- Advantage
- 55
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 22519
- Advantage
- 55
- Tel
- 18521735133 18521732826;
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25015
- Advantage
- 65
- Tel
- 021-61552785
- Fax
- 021-55660885
- sales@shshiji.com
- Country
- China
- ProdList
- 9552
- Advantage
- 55
- Tel
- 86-0755-86635001
- Fax
- 86-0755-22642228
- cantotech@126.com
- Country
- China
- ProdList
- 4576
- Advantage
- 55
- Tel
- 021-62960152
- Fax
- 021-52212593
- 934678158@qq.com
- Country
- China
- ProdList
- 9906
- Advantage
- 55
- Tel
- +86-28-85122536 85324413
- Fax
- +86-28-85326443
- market@astatech.cn
- Country
- China
- ProdList
- 8033
- Advantage
- 55
- Tel
- 021-60136491 15901897992
- Fax
- 021-60136492
- Country
- China
- ProdList
- 455
- Advantage
- 55
- Tel
- 021-61119791,13386096464
- Fax
- 021-50190009
- bzswkf@foxmail.com
- Country
- China
- ProdList
- 3924
- Advantage
- 50
- Tel
- 021-64975436 18917636693
- Fax
- 021-24280809
- 1377976036@qq.com
- Country
- China
- ProdList
- 298
- Advantage
- 55
- Tel
- 025-84683399 13952017251
- Fax
- 025-84683112
- sales@sinfachem.com
- Country
- China
- ProdList
- 217
- Advantage
- 56
- Tel
- 400-8706899
- Fax
- 400-8706899
- hysj_bj.com
- Country
- China
- ProdList
- 3585
- Advantage
- 55
View Lastest Price from D-Tryptophan methyl ester hydrochloride manufacturers
- Product
- D-Tryptophan methyl ester HCL 14907-27-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98+
- Supply Ability
- 1T
- Release date
- 2024-04-08
- Product
- D-Tryptophan methyl ester hydrochloride 14907-27-8
- Price
- US $75.00-750.00/KG
- Min. Order
- 1KG
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2023-10-20
- Product
- D-Tryptophan methyl ester hydrochloride 14907-27-8
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 500kgs
- Release date
- 2021-08-27