ChemicalBook > CAS DataBase List > (S)-2,2-dimethyl-1-(5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one

(S)-2,2-dimethyl-1-(5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one

Product Name: (S)-2,2-dimethyl-1-(5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one
CAS No.: 2049868-46-2
Chemical Name: (S)-2,2-dimethyl-1-(5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one
Synonyms: GSK'963;GSK963, 10 mM in DMSO;GSK-963;GSK 963;GSK'963;(S)-2,2-dimethyl-1-(5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one;1-Propanone, 1-[(5S)-4,5-dihydro-5-phenyl-1H-pyrazol-1-yl]-2,2-dimethyl-;GSK963,Inhibitor,RIP kinase,GSK 963,Receptor-interacting protein kinases,inhibit,GSK-963,RIPK
CBNumber: CB94656211
Molecular Formula: C14H18N2O
Formula Weight: 230.31
MOL File: 2049868-46-2.mol

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(S)-2,2-dimethyl-1-(5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one Property

Boiling point:: 342.8±45.0 °C(Predicted)
Density: 1.06±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 25 mg/mL (108.55 mM; Need ultrasonic)
form: Solid
pka: 0.98±0.40(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2376
Product name: GSK′963
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $132
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2376
Product name: GSK′963
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $528
Updated: 2025/07/31

TRC

Product number: G797815
Product name: GSK''963
Packaging: 1mg
Price: $220
Updated: 2021/12/16

DC Chemicals

Product number: 023013
Product name: GSK963
Packaging: 001
Price: $550
Updated: 2021/12/16

DC Chemicals

Product number: 023013
Product name: GSK963
Packaging: 002
Price: $950
Updated: 2021/12/16

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(S)-2,2-dimethyl-1-(5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one Chemical Properties,Usage,Production

Uses

GSK''963 is a novel highly potent and selective RIP1 inhibitor.

Biological Activity

GSKμ963 (GSKμ963A) is a brain-penetrant, highly potent and selective ATP site-targeting receptor-interacting protein 1 kinase (RIP1; RIPK1) inhibitor (IC50 = 0.8-8 nM with 50 μM ATP; IC50 >10 μM against RIPK2/3/5 and 335 other kinases) th at protects against TNFα/zVAD-induced necroptosis (EC50 = 1/4 nM in mouse L929/human U937 cultures) and blocks Y. pestis-induced death of murine fetal liver macrophages (1 μM). GSKμ963 prevents lethal hypothermia by acute sterile shock (2 mg/kg i.p. 15 min prior to TNFα/zVAD i.v.) and protects against acute neuronal death upon autologous blood intracerebral hemorrhage induction in mice in vivo (25 mg/kg/3 hr i.p.).

in vivo

GSK963 (2 mg/kg) results in a complete protection from TNF+zVAD-induced temperature loss. GSK963 (0.2 mg/kg) also shows a significant response^[1].

Animal Model:	C57BL/6 mice^[1].
Dosage:	0.2 mg/kg, 2 mg/kg, 10?mg/kg.
Administration:	IP once.
Result:	Protected mice from TNF+zVAD-induced hypothermia.

(S)-2,2-dimethyl-1-(5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one Preparation Products And Raw materials

Raw materials

Preparation Products

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2049868-46-2, (S)-2,2-dimethyl-1-(5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)propan-1-oneRelated Search:

(S)-2,2-dimethyl-1-(5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one

GSK'963

GSK-963;GSK 963;GSK'963

1-Propanone, 1-[(5S)-4,5-dihydro-5-phenyl-1H-pyrazol-1-yl]-2,2-dimethyl-

GSK963,Inhibitor,RIP kinase,GSK 963,Receptor-interacting protein kinases,inhibit,GSK-963,RIPK

GSK963, 10 mM in DMSO

2049868-46-2