PA-6

Product Name: PA-6
CAS No.: 500715-03-7
Chemical Name: PA-6
Synonyms: PA-6 >=98% (HPLC);IK1 inhibitor PA-6 (PA-6);IK1 inhibitor PA-6, 10 mM in DMSO;1,5-Bis[4-[[imino(phenyl)methyl]amino]phenoxy]pentane;Benzenecarboximidamide, N,N''-[1,5-pentanediylbis(oxy-4,1-phenylene)]bis-;N-(4-{[5-(4-benzeneimidamidophenoxy)pentyl]oxy}phenyl)benzenecarboximidamide;IK1 inhibitor PA-6,IK1 inhibitor PA 6,Inhibitor,PA 6,Potassium Channel,PA6,IK-1 inhibitor PA-6,inhibit,KcsA,PA-6,IK1 inhibitor PA6
CBNumber: CB94662564
Molecular Formula: C31H32N4O2
Formula Weight: 492.61
MOL File: 500715-03-7.mol

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PA-6 Property

Boiling point:: 648.1±65.0 °C(Predicted)
Density: 1.13±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 125 mg/mL (253.75 mM)
pka: 8.61±0.50(Predicted)
form: Solid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2185
Product name: PA-6
Purity: ≥98%(HPLC)
Packaging: 5mg
Price: $89.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2185
Product name: PA-6
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $360
Updated: 2025/07/31

ChemScene

Product number: CS-0046342
Product name: IK1inhibitorPA-6
Purity: 98.23%
Packaging: 50mg
Price: $500
Updated: 2021/12/16

ChemScene

Product number: CS-0046342
Product name: IK1inhibitorPA-6
Purity: 98.23%
Packaging: 10mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0046342
Product name: IK1inhibitorPA-6
Purity: 98.23%
Packaging: 25mg
Price: $300
Updated: 2021/12/16

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PA-6 Chemical Properties,Usage,Production

Uses

IK1 inhibitor PA-6 (PA-6), a pentamidine analogue, is a selective and potent IK1 (KIR2.x ion-channel-carried inward rectifier current) inhibitor, with IC50 values of 12-15 nM for human and mouse KIR2.x currents. IK1 inhibitor PA-6 (PA-6) elevates KIR2.1 protein expression and induces intracellular KIR2.1 accumulation. IK1 inhibitor PA-6 (PA-6) has the potential to treat atrial fibrillation and arrhythmia[1][2][3].

Biological Activity

PA-6 (Pentamidine-Analogue 6) is a selective and potent IK1 (inward rectifier potassium current) inhibitor th at terminates atrial fibrillation and does not cause ventricular arrhythmias in go at and dog models. PA-6 interacts with the cytoplasmic pore region of the KIR2.1 (KCNJ2) ion channel.

References

[1] Takanari H, et al. Efficient and specific cardiac IK? inhibition by a new pentamidine analogue. Cardiovasc Res. 2013 Jul 1;99(1):203-14. DOI:10.1093/cvr/cvt103
[2] Ji Y, et al. The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models. Br J Pharmacol. 2017 Aug;174(15):2576-2590. DOI:10.1111/bph.13869
[3] Ji Y, et al. PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression. J Biomed Sci. 2017 Jul 15;24(1):44. DOI:10.1186/s12929-017-0352-x

PA-6 Preparation Products And Raw materials

Raw materials

Preparation Products

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PA-6 Suppliers

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500715-03-7, PA-6Related Search:

PA-6 >=98% (HPLC)

1,5-Bis[4-[[imino(phenyl)methyl]amino]phenoxy]pentane

IK1 inhibitor PA-6,IK1 inhibitor PA 6,Inhibitor,PA 6,Potassium Channel,PA6,IK-1 inhibitor PA-6,inhibit,KcsA,PA-6,IK1 inhibitor PA6

Benzenecarboximidamide, N,N''-[1,5-pentanediylbis(oxy-4,1-phenylene)]bis-

N-(4-{[5-(4-benzeneimidamidophenoxy)pentyl]oxy}phenyl)benzenecarboximidamide

IK1 inhibitor PA-6, 10 mM in DMSO

IK1 inhibitor PA-6 (PA-6)

500715-03-7