ABI-H0731

Product Name: ABI-H0731
CAS No.: 2090064-66-5
Chemical Name: ABI-H0731
Synonyms: ABI-H0731;Vebicorvir, 10 mM in DMSO;antiviral,Inhibitor,Vebicorvir,inhibit,Hepatitis B virus,HBV,CHB,DBT;11-oxo-N-((2-(trifluoromethyl)thiazol-5-yl)methyl)-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxamide-5,5-dioxide;Dibenzo[b,f][1,4]thiazepine-8-carboxamide, 10,11-dihydro-11-oxo-N-[[2-(trifluoromethyl)-5-thiazolyl]methyl]-, 5,5-dioxide;5,5,11-Trioxo-10,11-dihydro-5H-dibenzo[b,f][1,4]thiazepine-8-carboxylic acid (2-trifluoromethyl-thiazol-5-ylmethyl)-amide;2,2,10-trioxo-N-{[2-(trifluoromethyl)-1,3-thiazol-5-yl]methyl}-2λ?-thia-9-azatricyclo[9.4.0.03,?]pentadeca-1(11),3(8),4,6,12,14-hexaene-6-carboxamide
CBNumber: CB94664326
Molecular Formula: C19H12F3N3O4S2
Formula Weight: 467.44
MOL File: 2090064-66-5.mol

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ABI-H0731 Property

Boiling point:: 566.3±50.0 °C(Predicted)
Density: 1.557±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (213.93 mM; Need ultrasonic)
form: Solid
pka: 11.14±0.20(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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ABI-H0731 Chemical Properties,Usage,Production

Uses

Vebicorvir (ABI-H0731) is a first-generation hepatitis B virus (HBV) core protein inhibitor. Vebicorvir (ABI-H0731) suppresses covalently closed circular DNA (cccDNA) formation in two de novo infection models with EC50s from 1.84 μM to 7.3 μM[1].

in vivo

After i.v. administration, the drug rapidly distributes and decayes in a biphasic manner in all species tested. Plasma clearance values of ABI-H0731 were 8.05, 10.1, 14.7, and 4.86 ml/min/kg, representing 9, 16, 47, and 11% of liver blood flow, in mouse, rat, dog, and monkey, respectively^[1].

References

[1] Qi Huang, et al. Preclinical Profile and Characterization of the Hepatitis B Virus Core Protein Inhibitor ABI-H0731. Antimicrob Agents Chemother. 2020 Oct 20;64(11):e01463-20. DOI:10.1128/AAC.01463-20

ABI-H0731 Preparation Products And Raw materials

Raw materials

Preparation Products

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ABI-H0731 Suppliers

China 27 United States 3 Global 30

Shanghai YuanQi Biotechnology Co., Ltd.

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2090064-66-5, ABI-H0731Related Search:

ABI-H0731

11-oxo-N-((2-(trifluoromethyl)thiazol-5-yl)methyl)-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxamide-5,5-dioxide

Dibenzo[b,f][1,4]thiazepine-8-carboxamide, 10,11-dihydro-11-oxo-N-[[2-(trifluoromethyl)-5-thiazolyl]methyl]-, 5,5-dioxide

antiviral,Inhibitor,Vebicorvir,inhibit,Hepatitis B virus,HBV,CHB,DBT

5,5,11-Trioxo-10,11-dihydro-5H-dibenzo[b,f][1,4]thiazepine-8-carboxylic acid (2-trifluoromethyl-thiazol-5-ylmethyl)-amide

2,2,10-trioxo-N-{[2-(trifluoromethyl)-1,3-thiazol-5-yl]methyl}-2λ?-thia-9-azatricyclo[9.4.0.03,?]pentadeca-1(11),3(8),4,6,12,14-hexaene-6-carboxamide

Vebicorvir, 10 mM in DMSO

2090064-66-5

C19H12F3N3O4S2