OSMI-1

ChemicalBook > CAS DataBase List > OSMI-1

Product Name: OSMI-1
CAS No.: 1681056-61-0
Chemical Name: OSMI-1
Synonyms: OSMI-1;OSMI-1 >=98% (HPLC);OSMI-1, O-GlcNAc transferase (OGT) inhibitor;(R)-N-(Furan-2-ylmethyl)-2-(2-methoxyphenyl)-2-(2-oxo-1,2-dihydroquinoline-6-sulfonamido)-N-(thiophen-2-ylmethyl)acetamide;Benzeneacetamide, α-[[(1,2-dihydro-2-oxo-6-quinolinyl)sulfonyl]amino]-N-(2-furanylmethyl)-2-methoxy-N-(2-thienylmethyl)-, (αR)-;cell-permeable,Inhibitor,OGT,Diacylglycerol acyltransferase,O-GlcNAcylation,toxicity,mammalian,inhibit,Acyltransferase,zebrafish,OSMI-1,acyl-CoA:cholesterol acyltransferase,Diglyceride acyltransferase,OSMI 1,OSMI1,O-GlcNAc,mono- acylglycerol acyltransferase,transferase
CBNumber: CB94666764
Molecular Formula: C28H25N3O6S2
Formula Weight: 563.64
MOL File: 1681056-61-0.mol

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OSMI-1 Property

Density: 1.389±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMF: 25 mg/mL; DMF:PBS (pH 7.2) (1:5): 0.16 mg/mL; DMSO: 20 mg/mL
form: powder
pka: 8.77±0.20(Predicted)
color: white to beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1621
Product name: OSMI-1
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $173
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1621
Product name: OSMI-1
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $689
Updated: 2023/06/20

Cayman Chemical

Product number: 21894
Product name: OSMI-1
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 21894
Product name: OSMI-1
Purity: ≥98%
Packaging: 5mg
Price: $145
Updated: 2024/03/01

Cayman Chemical

Product number: 21894
Product name: OSMI-1
Purity: ≥98%
Packaging: 10mg
Price: $261
Updated: 2024/03/01

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OSMI-1 Chemical Properties,Usage,Production

Uses

OSMI 1 is a novel inhibitor of O-GlcNAc transferase (OGT).

Uses

OSMI-1 (OGT with a small molecule inhibitor) has been used in proximal ligation assay, Sox2 (SRY (sex determining region Y)-Box 2 ) dual luciferase reporter assay, Sox2 ELISA (enzyme linked immunosorbent assay) and other in vivo approaches, to study the O-Linked β-N-acetylglucosamine (O-GlcNAc) mediated regulation of self-renewal genes in cancer. It has also been used to study the Hippo pathway regulation mediated by O-GlcNAc transferase.

Definition

ChEBI: OSMI-1 is a sulfonamide resulting from the formal condensation of the sulfonic acid group of 2-oxo-1,2-dihydroquinoline-6-sulfonic acid with the primary amino group of (2R)-2-amino-N-(2-furylmethyl)-2-(2-methoxyphenyl)-N-(2-thienylmethyl)acetamide. OSMI-1 is a cell permeable inhibitor of O-linked beta-N-acetylglucosamine transferase (O-GlcNAc transferase, OGT). It has a role as an EC 2.* (transferase) inhibitor and an EC 2.4.1.255 (protein O-GlcNAc transferase) inhibitor. It is a sulfonamide, a member of quinolines, a member of furans, a member of thiophenes, an aromatic ether and a tertiary carboxamide.

Biochem/physiol Actions

OGT catalyses the attachment of N-acetylglucosamine moieties to a number proteins during post-translational modification. Inhibition of OGT activity might hinder the rate of viral replication in infections such as Herpes simplex viral disease.

OSMI-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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1681056-61-0, OSMI-1Related Search:

OSMI-1

Benzeneacetamide, α-[[(1,2-dihydro-2-oxo-6-quinolinyl)sulfonyl]amino]-N-(2-furanylmethyl)-2-methoxy-N-(2-thienylmethyl)-, (αR)-

OSMI-1 >=98% (HPLC)

(R)-N-(Furan-2-ylmethyl)-2-(2-methoxyphenyl)-2-(2-oxo-1,2-dihydroquinoline-6-sulfonamido)-N-(thiophen-2-ylmethyl)acetamide

cell-permeable,Inhibitor,OGT,Diacylglycerol acyltransferase,O-GlcNAcylation,toxicity,mammalian,inhibit,Acyltransferase,zebrafish,OSMI-1,acyl-CoA:cholesterol acyltransferase,Diglyceride acyltransferase,OSMI 1,OSMI1,O-GlcNAc,mono- acylglycerol acyltransferase,transferase

OSMI-1, O-GlcNAc transferase (OGT) inhibitor

1681056-61-0

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