9-ING-41

Use In vivo In vitro

Product Name: 9-ING-41
CAS No.: 1034895-42-5
Chemical Name: 9-ING-41
Synonyms: 9-ING-41;9-ING-41 USP/EP/BP;3-(5-Fluoro-3-benzofuranyl)-4-(5-methyl-5H-1,3-dioxolo[4,5-f]indol-7-yl)-1H-pyrrole-2,5-dione;3-(5-fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-(5-fluoro-3-benzofuranyl)-4-(5-methyl-5H-1,3-dioxolo[4,5-f]indol-7-yl)-;9-ING-41 3-?(5-?Fluorobenzofuran-?3-?yl)?-?4-?(5-?methyl-?5H- ?[1,?3]?dioxolo[4,?5-?f]?indol-?7-?yl)?pyrrole-?2,?5-?dione;cycle,GSK-3,cell,inhibit,9ING41,Apoptosis,Inhibitor,Glycogen synthase kinase 3,9 ING 41,arrest,Glycogen synthase kinase-3,anticancer,Autophagy,GSK-3β,activity
CBNumber: CB94667468
Molecular Formula: C22H13FN2O5
Formula Weight: 404.35
MOL File: 1034895-42-5.mol

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9-ING-41 Property

Boiling point:: 649.5±55.0 °C(Predicted)
Density: 1.63±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 2 mg/ml; DMSO: 1 mg/ml; Ethanol: insol; PBS (pH 7.2): insol
form: A solid
pka: 7.23±0.60(Predicted)
color: Pink to red

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0063319
Product name: 9-ING-41
Purity: 99.32%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-0063319
Product name: 9-ING-41
Purity: 99.32%
Packaging: 10mg
Price: $200
Updated: 2021/12/16

ChemScene

Product number: CS-0063319
Product name: 9-ING-41
Purity: 99.32%
Packaging: 25mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-0063319
Product name: 9-ING-41
Purity: 99.32%
Packaging: 50mg
Price: $750
Updated: 2021/12/16

ChemScene

Product number: CS-0063319
Product name: 9-ING-41
Purity: 99.32%
Packaging: 100mg
Price: $1300
Updated: 2021/12/16

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9-ING-41 Chemical Properties,Usage,Production

Use

9-ING-41 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with antitumor activity. 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β.

In vivo

9-ING-41 has single-agent antitumor activity in a mouse model of MCL. Mouse xenograft studies shows that the combination of clinically relevant doses of CPT-11 and 9-ING-41 lead to greater antitumor effect than is observed with either agent alone.

In vitro

9-ING-41, a clinically relevant small molecule GSK-3β inhibitor with broad spectrum pre-clinical antitumor activity, suppresses the growth of neuroblastoma cells.9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β.

Uses

3-(5-Fluoro-3-benzofuranyl)-4-(5-methyl-5H-1,3-dioxolo[4,5-f]indol-7-yl)-1H-pyrrole-2,5-dione induces apoptosis in human ovarian cells and also inhibits tumor growth in xenografted rat.

9-ING-41 Preparation Products And Raw materials

Raw materials

Preparation Products

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9-ING-41 Suppliers

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1034895-42-5, 9-ING-41Related Search:

9-ING-41

9-ING-41 USP/EP/BP

3-(5-Fluoro-3-benzofuranyl)-4-(5-methyl-5H-1,3-dioxolo[4,5-f]indol-7-yl)-1H-pyrrole-2,5-dione

9-ING-41 3-?(5-?Fluorobenzofuran-?3-?yl)?-?4-?(5-?methyl-?5H- ?[1,?3]?dioxolo[4,?5-?f]?indol-?7-?yl)?pyrrole-?2,?5-?dione

3-(5-fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)-1H-pyrrole-2,5-dione

cycle,GSK-3,cell,inhibit,9ING41,Apoptosis,Inhibitor,Glycogen synthase kinase 3,9 ING 41,arrest,Glycogen synthase kinase-3,anticancer,Autophagy,GSK-3β,activity

1H-Pyrrole-2,5-dione, 3-(5-fluoro-3-benzofuranyl)-4-(5-methyl-5H-1,3-dioxolo[4,5-f]indol-7-yl)-

1034895-42-5

9-ING-41