9-ING-41
Use In vivo In vitro- Product Name
- 9-ING-41
- CAS No.
- 1034895-42-5
- Chemical Name
- 9-ING-41
- Synonyms
- 9-ING-41;9-ING-41 USP/EP/BP;3-(5-Fluoro-3-benzofuranyl)-4-(5-methyl-5H-1,3-dioxolo[4,5-f]indol-7-yl)-1H-pyrrole-2,5-dione;3-(5-fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-(5-fluoro-3-benzofuranyl)-4-(5-methyl-5H-1,3-dioxolo[4,5-f]indol-7-yl)-;9-ING-41 3-?(5-?Fluorobenzofuran-?3-?yl)?-?4-?(5-?methyl-?5H- ?[1,?3]?dioxolo[4,?5-?f]?indol-?7-?yl)?pyrrole-?2,?5-?dione;cycle,GSK-3,cell,inhibit,9ING41,Apoptosis,Inhibitor,Glycogen synthase kinase 3,9 ING 41,arrest,Glycogen synthase kinase-3,anticancer,Autophagy,GSK-3β,activity
- CBNumber
- CB94667468
- Molecular Formula
- C22H13FN2O5
- Formula Weight
- 404.35
- MOL File
- 1034895-42-5.mol
9-ING-41 Property
- Boiling point:
- 649.5±55.0 °C(Predicted)
- Density
- 1.63±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 2 mg/ml; DMSO: 1 mg/ml; Ethanol: insol; PBS (pH 7.2): insol
- form
- A solid
- pka
- 7.23±0.60(Predicted)
N-Bromosuccinimide Price
- Product number
- CS-0063319
- Product name
- 9-ING-41
- Purity
- 99.32%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- CS-0063319
- Product name
- 9-ING-41
- Purity
- 99.32%
- Packaging
- 10mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- CS-0063319
- Product name
- 9-ING-41
- Purity
- 99.32%
- Packaging
- 25mg
- Price
- $420
- Updated
- 2021/12/16
- Product number
- CS-0063319
- Product name
- 9-ING-41
- Purity
- 99.32%
- Packaging
- 50mg
- Price
- $750
- Updated
- 2021/12/16
- Product number
- CS-0063319
- Product name
- 9-ING-41
- Purity
- 99.32%
- Packaging
- 100mg
- Price
- $1300
- Updated
- 2021/12/16
9-ING-41 Chemical Properties,Usage,Production
Use
9-ING-41 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with antitumor activity. 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β.
In vivo
9-ING-41 has single-agent antitumor activity in a mouse model of MCL. Mouse xenograft studies shows that the combination of clinically relevant doses of CPT-11 and 9-ING-41 lead to greater antitumor effect than is observed with either agent alone.
In vitro
9-ING-41, a clinically relevant small molecule GSK-3β inhibitor with broad spectrum pre-clinical antitumor activity, suppresses the growth of neuroblastoma cells.9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β.
Uses
3-(5-Fluoro-3-benzofuranyl)-4-(5-methyl-5H-1,3-dioxolo[4,5-f]indol-7-yl)-1H-pyrrole-2,5-dione induces apoptosis in human ovarian cells and also inhibits tumor growth in xenografted rat.
9-ING-41 Preparation Products And Raw materials
Raw materials
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