Azelaprag

Product Name: Azelaprag
CAS No.: 2049980-18-7
Chemical Name: Azelaprag
Synonyms: BGE-105;AMG 986;Azelaprag;Azelaprag (AMG 986);(2S,3R)-N-(4-(2,6-Dimethoxyphenyl)-5-(5-methylpyridin-3-yl)-4H-1,2,4-triazol-3-yl)-3-(5-methylpyrimidin-2-yl)butane-2-sulfonamide;2-Pyrimidineethanesulfonamide, N-[4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl]-α,β,5-trimethyl-, (αS,βR)-
CBNumber: CB94667600
Molecular Formula: C25H29N7O4S
Formula Weight: 523.61
MOL File: 2049980-18-7.mol

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Azelaprag Property

Boiling point:: 738.0±70.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 4.43±0.10(Predicted)
color: White to light yellow
InChIKey: DOMQFIFVDIAOOT-HCAOVKSPNA-N
SMILES: N(C1=NN=C(C2=CN=CC(C)=C2)N1C1C(=CC=CC=1OC)OC)S(=O)(=O)[C@@H](C)[C@@H](C1=NC=C(C)C=N1)C |&1:26,28,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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Azelaprag Chemical Properties,Usage,Production

Uses

Azelaprag (Example 263.0) is a candidate active molecule for an Apelin receptor agonist with an EC50 of 0.32 nM for the apelin receptor[1].

References

[1] WO2016187308A1.
[2] Ason B, et.al. Cardiovascular response to small-molecule APJ activation. JCI Insight. 2020 Apr 23;5(8):e132898. DOI:10.1172/jci.insight.132898

Azelaprag Preparation Products And Raw materials

Raw materials

Preparation Products

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Azelaprag Suppliers

China 31 United States 2 Global 33

Anhui JYHX CO., LTD.

Tel: 055167162561 13295518198
Email: wangyanan@ahjyhx.com
Country: China
ProdList: 1760
Advantage: 58

Nanjing Yiming Pharmaceutical Technology Co., Ltd.

Tel: 19850700912
Email: 13851286085@163.com
Country: China
ProdList: 500
Advantage: 58

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070 13913916777
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16059
Advantage: 64

Chengdu DingDang Pharmaceutical Co., Ltd.

Tel: 028-86040038 13980902949;
Fax: 028-85149890
Email: market@dingdangchem.com
Country: China
ProdList: 1854
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
Advantage: 60

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 028-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 8556
Advantage: 58

Jinan Kabotang Biological Technology Co.,Ltd.

Tel: 0531-61320525 15866703830
Email: figo.gao@foxmail.com
Country: China
ProdList: 6625
Advantage: 58

Jinan Carbotang Biotech Co.,Ltd.

Tel: +8615866703830
Email: figo.gao@foxmail.com
Country: China
ProdList: 8497
Advantage: 58

Henan Alpha Chemical Co., Ltd.

Tel: 0371-55055611 18137792234
Email: 3957071458@qq.com
Country: China
ProdList: 9897
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32467
Advantage: 58

2049980-18-7, AzelapragRelated Search:

Azelaprag

AMG 986

2-Pyrimidineethanesulfonamide, N-[4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl]-α,β,5-trimethyl-, (αS,βR)-

Azelaprag (AMG 986)

(2S,3R)-N-(4-(2,6-Dimethoxyphenyl)-5-(5-methylpyridin-3-yl)-4H-1,2,4-triazol-3-yl)-3-(5-methylpyrimidin-2-yl)butane-2-sulfonamide

BGE-105

2049980-18-7