CLP257

Product Name: CLP257
CAS No.: 1181081-71-9
Chemical Name: CLP257
Synonyms: CLP257;CLP257, 10 mM in DMSO;(Z)-5-(4-fluoro-2-hydroxybenzylidene)-2-(tetrahydropyridazin-1(2H)-yl)thiazol-4(5H)-one;(5Z)-5-[(4-Fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1-(2H)-pyridazinyl)-4(5H)-thiazolone;4(5H)-Thiazolone, 5-[(4-fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1(2H)-pyridazinyl)-, (5Z)-;Inhibitor,post-translationally,hypersensitivity,plasma,Potassium Channel,neuropathic,antihyperalgesic,CLP 257,membrane,KcsA,mechanical,sensitivity,CLP-257,CLP257,KCC2,inhibit
CBNumber: CB94667761
Molecular Formula: C14H14FN3O2S
Formula Weight: 307.34
MOL File: 1181081-71-9.mol

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CLP257 Property

Boiling point:: 473.3±55.0 °C(Predicted)
Density: 1.50±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 20 mg/ml
form: powder
pka: 7.23±0.40(Predicted)
color: white to yellow to light brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1368
Product name: CLP257
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $136
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1368
Product name: CLP257
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $374.5
Updated: 2025/07/31

Tocris

Product number: 5242
Product name: CLP257
Purity: ≥98%(HPLC)
Packaging: 10
Price: $210
Updated: 2021/12/16

Tocris

Product number: 5242
Product name: CLP257
Purity: ≥98%(HPLC)
Packaging: 50
Price: $878
Updated: 2021/12/16

Usbiological

Product number: 255013
Product name: CLP 257
Packaging: 10mg
Price: $460
Updated: 2021/12/16

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CLP257 Chemical Properties,Usage,Production

Uses

CLP257 has been used as a K⁺- Cl^-cotransporter 2 (KCC2) enhancer in human neuron culture.

Biochem/physiol Actions

CLP257 is a selective K+-Cl? cotransporter KCC2 activator that restored impaired Cl? transport in neurons with reduced KCC2 activity. Apparently, CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally.

storage

Store at +4°C

CLP257 Preparation Products And Raw materials

Raw materials

Preparation Products

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CLP257 Suppliers

China 32 United Kingdom 1 United States 8 Global 41

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1181081-71-9, CLP257Related Search:

(5Z)-5-[(4-Fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1-(2H)-pyridazinyl)-4(5H)-thiazolone

CLP257

4(5H)-Thiazolone, 5-[(4-fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1(2H)-pyridazinyl)-, (5Z)-

Inhibitor,post-translationally,hypersensitivity,plasma,Potassium Channel,neuropathic,antihyperalgesic,CLP 257,membrane,KcsA,mechanical,sensitivity,CLP-257,CLP257,KCC2,inhibit

(Z)-5-(4-fluoro-2-hydroxybenzylidene)-2-(tetrahydropyridazin-1(2H)-yl)thiazol-4(5H)-one

CLP257, 10 mM in DMSO

1181081-71-9