ChemicalBook > CAS DataBase List > CLP257

CLP257

Product Name
CLP257
CAS No.
1181081-71-9
Chemical Name
CLP257
Synonyms
CLP257;CLP257, 10 mM in DMSO;(Z)-5-(4-fluoro-2-hydroxybenzylidene)-2-(tetrahydropyridazin-1(2H)-yl)thiazol-4(5H)-one;(5Z)-5-[(4-Fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1-(2H)-pyridazinyl)-4(5H)-thiazolone;4(5H)-Thiazolone, 5-[(4-fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1(2H)-pyridazinyl)-, (5Z)-;Inhibitor,post-translationally,hypersensitivity,plasma,Potassium Channel,neuropathic,antihyperalgesic,CLP 257,membrane,KcsA,mechanical,sensitivity,CLP-257,CLP257,KCC2,inhibit
CBNumber
CB94667761
Molecular Formula
C14H14FN3O2S
Formula Weight
307.34
MOL File
1181081-71-9.mol
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CLP257 Property

Boiling point:
473.3±55.0 °C(Predicted)
Density 
1.50±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 20 mg/ml
form 
powder
pka
7.23±0.40(Predicted)
color 
white to yellow to light brown
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1368
Product name
CLP257
Purity
≥98% (HPLC)
Packaging
5MG
Price
$129
Updated
2023/06/20
Sigma-Aldrich
Product number
SML1368
Product name
CLP257
Purity
≥98% (HPLC)
Packaging
25MG
Price
$507
Updated
2023/06/20
Tocris
Product number
5242
Product name
CLP257
Purity
≥98%(HPLC)
Packaging
50
Price
$878
Updated
2021/12/16
Tocris
Product number
5242
Product name
CLP257
Purity
≥98%(HPLC)
Packaging
10
Price
$210
Updated
2021/12/16
Usbiological
Product number
255013
Product name
CLP 257
Packaging
10mg
Price
$460
Updated
2021/12/16
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CLP257 Chemical Properties,Usage,Production

Uses

CLP257 has been used as a K+- Cl- cotransporter 2 (KCC2) enhancer in human neuron culture.

Biochem/physiol Actions

CLP257 is a selective K+-Cl? cotransporter KCC2 activator that restored impaired Cl? transport in neurons with reduced KCC2 activity. Apparently, CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally.

storage

Store at +4°C

CLP257 Preparation Products And Raw materials

Raw materials

Preparation Products

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CLP257 Suppliers

China 25 United Kingdom 1 United States 7 Global 33
Nanjing Chemlin Chemical Co., Ltd
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025-83697070 19951945301
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info@chemlin.com.cn
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China
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Sigma-Aldrich
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021-61415566 800-8193336
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orderCN@merckgroup.com
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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Shanghai Rechem science Co., Ltd.
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21-31433387 15618786686
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QQ:1369748377
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sales@rechemscience.com
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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Sales@ATKchemical.com
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Shanghai Hongye Biotechnology Co. Ltd
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400-9205774
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sales@glpbio.cn
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HANGZHOU CLAP TECHNOLOGY CO.,LTD
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sales@hzclap.com
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DC Chemicals
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021-58447131 13564518121
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sales@dcchemicals.com
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0519-85788828 13775037613
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sales@chemrenpharm.com
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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Bide Pharmatech Ltd.
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TargetMol Chemicals Inc.
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Suzhou Zhixin Biotechnology Co., Ltd.
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Nanjing Shizhou Biology Technology Co.,Ltd
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1181081-71-9, CLP257Related Search:


  • (5Z)-5-[(4-Fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1-(2H)-pyridazinyl)-4(5H)-thiazolone
  • CLP257
  • 4(5H)-Thiazolone, 5-[(4-fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1(2H)-pyridazinyl)-, (5Z)-
  • Inhibitor,post-translationally,hypersensitivity,plasma,Potassium Channel,neuropathic,antihyperalgesic,CLP 257,membrane,KcsA,mechanical,sensitivity,CLP-257,CLP257,KCC2,inhibit
  • (Z)-5-(4-fluoro-2-hydroxybenzylidene)-2-(tetrahydropyridazin-1(2H)-yl)thiazol-4(5H)-one
  • CLP257, 10 mM in DMSO
  • 1181081-71-9