ChemicalBook > CAS DataBase List > LIT-927
LIT-927
- Product Name
- LIT-927
- CAS No.
- 2172879-52-4
- Chemical Name
- LIT-927
- Synonyms
- LIT-927;CS-2869;2(1H)-Pyrimidinone, 4-(4-chlorophenyl)-6-(4-hydroxy-3-methoxyphenyl)-
- CBNumber
- CB94668137
- Molecular Formula
- C17H13ClN2O3
- Formula Weight
- 328.75
- MOL File
- 2172879-52-4.mol
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LIT-927 Property
- storage temp.
- Store at -20°C
- solubility
- DMSO:66.0(Max Conc. mg/mL);200.76(Max Conc. mM)
- form
- A solid
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML2893
- Product name
- LIT-927
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $94.2
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- SML2893
- Product name
- LIT-927
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $306
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 28436
- Product name
- LIT-927
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 28436
- Product name
- LIT-927
- Packaging
- 50mg
- Price
- $547
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 28436
- Product name
- LIT-927
- Packaging
- 10mg
- Price
- $146
- Updated
- 2024/03/01
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LIT-927 Chemical Properties,Usage,Production
Biochem/physiol Actions
LIT-927 is an orally active CXCL12 (SDF1) neutraligand (Kd = 267) that selectively neutralizes CXCL12, but not CCL17, CCL22, CCL5, or CCL2 activity in cultures (10 μM LIT-927 against 5 nM chemokine-induced calcium mobilization). LIT-927 reduces eosinophil recruitment in a murine allergic airway hypereosinophilia model in vivo (330 nmol/kg intranasal, 350 nmol/kg ip. or 1400 μmol/kg po.), offering greatly improved oral activity and solubility than Chalcone-4, and exhibiting little side-effects when compared with dexamethasone or CXCR4 antagonist AMD3100.
LIT-927 Preparation Products And Raw materials
Raw materials
Preparation Products
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LIT-927 Suppliers
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