MN58b

Product Name: MN58b
CAS No.: 203192-01-2
Chemical Name: MN58b
Synonyms: MN58b;MN58b,inhibit,Apoptosis,Inhibitor,MN-58b;1,1'-((Butane-1,4-diylbis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide;1,1'-((Butane-1,4-diylbis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide;Pyridinium, 1,?1'-?[1,?4-?butanediylbis(4,?1-?phenylenemethylene)?]?bis[4-?(dimethylamino)?-?, bromide (1:2);1-[[4-[4-[4-[[4-(dimethylamino)pyridin-1-ium-1-yl]methyl]phenyl]butyl]phenyl]methyl]-N,N-dimethylpyridin-1-ium-4-amine
CBNumber: CB94668218
Molecular Formula: C32H40BrN4+
Formula Weight: 560.6
MOL File: 203192-01-2.mol

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MN58b Property

storage temp.: Store at -20°C
solubility: DMSO:14.71(Max Conc. mg/mL);22.97(Max Conc. mM)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

DC Chemicals

Product number: DC21335
Product name: MN58b
Purity: >98%
Packaging: 100mg
Price: $900
Updated: 2021/12/16

DC Chemicals

Product number: DC21335
Product name: MN58b
Purity: >98%
Packaging: 250mg
Price: $1600
Updated: 2021/12/16

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MN58b Chemical Properties,Usage,Production

Biological Activity

MN58b is a selective choline kinase α (CHKα) inhibitor that inhibits phosphorylcholine synthesis.It reduces cell growth by inducing apoptosis and has antitumor activity.

in vitro

The IC ₅₀ s of MN58b for parental and Gemcitabine-resistant Suit2 007 cells are 3.14 μM and 0.77 μM, respectively.
It has a marked effect on colony formation at 1 μM, and growth is completely abolished at 5 μM in all the cell lines.
It induces apoptosis and this response correlates with CHKα expression.

Cell Viability Assay

Cell Line:	SK-PC-1 , Suit2 008, IMIM-PC2, and RWP-1 cells
Concentration:	1 μM, 5 μM
Incubation Time:	72 hours
Result:	Inhibited ce lls growth.

Apoptosis Analysis

Cell Line:	SK-PC-1, Suit2 008, IMIM-PC2, and RWP -1 cells
Concentration:	1 μM, 2 μM, 5 μM, 10 μM
Incubation Time:	24 and 48 hours
Result:	Induced cell apoptosis.

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in vivo

MN58b (4 mg/kg; intraperitoneal injection; once a day; for 5 days; MF-1 nude mice) treatment significantly decreases phosphomonoesters in both HT29 and MDA-MB-231 xenografts. Phosphocholine levels are found to correlate with choline kinase activities.

Animal Model:	MF-1 nude mice with HT29 or MDA-MB-231 cells
Dosage:	4 mg/kg
Administration:	Intraperitoneal injection; once a day; for 5 days
Result :	Phosphomonoesters decreased significantly.

target

Choline kinase α (CHKα)

MN58b Preparation Products And Raw materials

Raw materials

Preparation Products

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MN58b Suppliers

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203192-01-2, MN58bRelated Search:

MN58b

1-[[4-[4-[4-[[4-(dimethylamino)pyridin-1-ium-1-yl]methyl]phenyl]butyl]phenyl]methyl]-N,N-dimethylpyridin-1-ium-4-amine

MN58b,inhibit,Apoptosis,Inhibitor,MN-58b

1,1'-((Butane-1,4-diylbis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide

Pyridinium, 1,?1'-?[1,?4-?butanediylbis(4,?1-?phenylenemethylene)?]?bis[4-?(dimethylamino)?-?, bromide (1:2)

1,1'-((Butane-1,4-diylbis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide

203192-01-2