TFLLR-NH2(TFA)

Product Name: TFLLR-NH2(TFA)
CAS No.: 1313730-19-6
Chemical Name: TFLLR-NH2(TFA)
Synonyms: TFLLR-NH2(TFA);197794-83-5 (Thr1)-TRAP-5 amide;(S)-2-((S)-2-((2S,3R)-2-Amino-3-hydroxybutanamido)-3-phenylpropanamido)-N-((S)-1-(((S)-1-amino-5-guanidino-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-4-methylpentanamide 2,2,2-trifluoroacetate
CBNumber: CB94713833
Molecular Formula: C33H54F3N9O8
Formula Weight: 761.85
MOL File: 1313730-19-6.mol

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TFLLR-NH2(TFA) Property

storage temp.: Store at -20°C
solubility: Water: 100 mg/mL (131.26 mM); DMSO: 100 mg/mL (131.26 mM)
form: Solid
color: White to off-white
Sequence: H-Thr-Phe-Leu-Leu-Arg-NH2

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0058948
Product name: TFLLR-NH2(TFA)
Purity: 99.29%
Packaging: 1mg
Price: $216
Updated: 2021/12/16

ChemScene

Product number: CS-0058948
Product name: TFLLR-NH2(TFA)
Purity: 99.29%
Packaging: 5mg
Price: $864
Updated: 2021/12/16

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TFLLR-NH2(TFA) Chemical Properties,Usage,Production

Biological Activity

TFLLR-NH2 (TFA) is a selective PAR1 agonist with an EC50 of 1.9 μM.

in vitro

PAR1 agonists stimulate concentration-dependent increases in [Ca ²⁺ ]i and in the proportions of neurones. The maximal increase in [Ca ²⁺ ] i above basal is detected in response to 10 μm TF-NH2 (peak 196.5±20.4 nM, n=25) when 50–80% of identified neurones responded. SW620 cells cultured in the supernatant of TFLLR-NH2-activated platelets upregulate E- cadherin expression and downregulate the vimentin expression. In the in vitro platelet culture system, a TFLLR-NH2 dose-dependent increase of secreted TGF-β1 is detected in the supernatant.

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in vivo

Injection of TF-NH2 into the rat paw stimulates a marked and sustained oedema. An NK1R antagonist and ablation of sensory nerves with capsaicin inhibit oedema by 44% at 1 h and completely by 5 h. In wild-type but not PAR1 ^?/? mice, TF-NH2 stimulates Evans blue extravasation in the bladder, oesophagus, stomach, intestine and pancreas by 2–8 fold. Extravasation in the bladder, oesophagus and stomach is abolished by an NK1R antagonist. TFp-NH2 produces notable contraction at 3-50 μM and relaxation at 0.3-50 μM, in the absence of apamin. The concentration-response curve for TFp-NH2-induced contraction is remarkably shifted left, when the TFp- NH2-induced relaxation is blocked by apamin at 0.1 μM.

target

EC50: 1.9 μM (PAR1)

TFLLR-NH2(TFA) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from TFLLR-NH2(TFA) manufacturers

Career Henan Chemical Co

Product: TFLLR-NH2(TFA) 1313730-19-6
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-13

1313730-19-6, TFLLR-NH2(TFA)Related Search:

ETHYLENEDIAMINE TETRAKIS(PROPOXYLATE-BLOCK-ETHOXYLATE) TETROL

TFLLR-NH2(TFA)

197794-83-5 (Thr1)-TRAP-5 amide

(S)-2-((S)-2-((2S,3R)-2-Amino-3-hydroxybutanamido)-3-phenylpropanamido)-N-((S)-1-(((S)-1-amino-5-guanidino-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-4-methylpentanamide 2,2,2-trifluoroacetate

1313730-19-6