ChemicalBook > CAS DataBase List > 3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCL

3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCL

Product Name
3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCL
CAS No.
2242751-53-5
Chemical Name
3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCL
Synonyms
AG10 hydrochloride;Acoramidis hydrochloride;Acoramidis hydrochloride, 10 mM in DMSO;Acoramidis?hydrochloride?(AG10 hydrochloride);3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCL;3-(3-(3,5-Dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid hydrochloride
CBNumber
CB94800979
Molecular Formula
C15H18ClFN2O3
Formula Weight
328.77
MOL File
2242751-53-5.mol
More
Less

3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCL Property

solubility 
DMSO: Sparingly soluble: 1-10 mg/ml
form 
Solid
color 
White to light yellow
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCL Chemical Properties,Usage,Production

Uses

Acoramidis (AG10) hydrochloride is an orally active and selective kinetic stabilizer of WT and V122I-TTR (transthyretin). Acoramidis (AG10) hydrochloride is used in the study for transthyretin amyloidosis[1][2].

in vivo

Animal Model:Wistar rats[1].
Dosage:50 mg/kg/d (Toxicity Analysis).
Administration:Oral gavage, daily for 28 d.
Result:Showed the plasma Cmax of ～40 μM and histopathological evaluation of liver, kidney, heart, spleen, thymus, and lung showed no signs of pathologic processes in the AG10-treated animals

References

[1] Sravan C Penchala, et al. AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9992-7. DOI:10.1073/pnas.1300761110
[2] Jonathan C Fox, et al. First-in-Human Study of AG10, a Novel, Oral, Specific, Selective, and Potent Transthyretin Stabilizer for the Treatment of Transthyretin Amyloidosis: A Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study in Healthy Adult Volunteers. Clin Pharmacol Drug Dev. 2020 Jan;9(1):115-129. DOI:10.1002/cpdd.700
[3] Stephen P Soltoff, et al. Evidence that tyrphostins AG10 and AG18 are mitochondrial uncouplers that alter phosphorylation-dependent cell signaling. J Biol Chem. 2004 Mar 19;279(12):10910-8. DOI:10.1074/jbc.M305396200

3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCL Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCL Suppliers

China 31 United States 2 Global 33
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 18971495150;
Email
sales@sun-shinechem.com
Country
China
ProdList
1077
Advantage
64
Shanghai Famo Bio-chemical Technology Company Ltd.
Tel
021-02136680027 15800370750
Email
1706640024@qq.com
Country
China
ProdList
570
Advantage
56
Suli Pharmaceutical Technology Co., Ltd.
Tel
021-58086325-8060 13636568474
Fax
021-51972827
Email
yingjie.zhang@suli.com
Country
China
ProdList
100
Advantage
58
Shanghai Synteam Biochem CO.,ltd
Tel
+86-021-58380978 13482386415
Fax
021-58380978
Email
info@systeambc.com
Country
China
ProdList
896
Advantage
50
Shanghai Beckham Medical Technology Co., Ltd
Tel
13816613772
Fax
QQ: 12922499
Email
huahero21@sina.com
Country
China
ProdList
2391
Advantage
55
MQ (shanghai) Pharmaceuticals Co., Ltd.
Tel
13761635123
Fax
1014988033@qq
Email
1014988033@qq.com
Country
China
ProdList
4941
Advantage
55
Suzhou Rovathin Foreign Trade Co.,Ltd
Tel
0512-65816829 18662214788
Fax
0512-65816829
Email
info@rovathin.com.cn
Country
China
ProdList
9987
Advantage
58
Shanghai Pleikon Chemical Technology Co., Ltd
Tel
021-021-54321516 17717324060
Email
2719672468@qq.com
Country
China
ProdList
1880
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
59936
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Pushan Industry (Shaanxi) Co., Ltd.
Tel
029-81310890 13571859809
Email
info@pushanshiye.com
Country
China
ProdList
9955
Advantage
58
Suzhou Haiben Pharmaceutical Co., Ltd
Tel
19353112242
Email
1816280386@qq.com
Country
China
ProdList
8045
Advantage
58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11973
Advantage
58
Soochow Chirally Material Science and Technology Co.,Ltd
Tel
0512-66834346 17751187418
Email
sales@krl-tech.com
Country
China
ProdList
1113
Advantage
58
Arizest(Shanghai)Pharmatech Co.,Ltd
Tel
13671599112
Email
geshi.zhuang@synovent.cn
Country
China
ProdList
426
Advantage
58
RD International Technology Co., Limited
Tel
18024082417
Email
market@ubiochem.com
Country
China
ProdList
9835
Advantage
58
CAREBIO PHARMA
Tel
18501057619 18501057619;
Email
jackyfan@rebornpharma.com
Country
China
ProdList
265
Advantage
58
Nanjing Hongwang Pharmaceutical Technology Co., Ltd
Tel
15366073145
Email
3016wan@163.com
Country
China
ProdList
623
Advantage
58
Shandong Dongde New Materials Co., Ltd
Tel
13290191024
Email
3887351301@qq.com
Country
China
ProdList
1910
Advantage
58
JIANGXI HANHE PHARMACEUTICAL CO.,LTD
Tel
18721221949
Email
zhangle@jxhhzy.com
Country
China
ProdList
102
Advantage
58
Sangon Biotech (Shanghai) Co.,Ltd.
Tel
400-821-026
Email
Sales@sangon.com
Country
China
ProdList
6710
Advantage
58
Nanjing Yikangda Pharmaceutical Technology Co.LTD
Tel
18118984557; 18118984557
Email
753016615@qq.com
Country
China
ProdList
498
Advantage
58
Cayman Chemical Company
Tel
800-364-9897
Email
sales@caymanchem.com
Country
China
ProdList
6838
Advantage
58
Shanghai Yaoheping Biopharmaceutical Technology Co., Ltd
Tel
021-57540919 13120888836
Email
lily@yhp-biomedicine.com
Country
China
ProdList
8254
Advantage
58
Soochow Chirally Material Science and Technology Co.,Ltd
Tel
+86-51266834346 +86-17751128648
Email
sales@krl-tech.com
Country
China
ProdList
942
Advantage
58
Chongqing jooe co., ltd
Tel
+undefined86-15223382610
Email
info@jooe.com
Country
China
ProdList
6208
Advantage
58
Shanghai Hanhong Scientific Co., Ltd.
Tel
+undefined17612118332
Email
Lucky@hanhonggroup.com
Country
China
ProdList
5844
Advantage
58
Shaanxi Dideu New Materials Co. Ltd
Tel
+86-18192503167 18192503167;
Email
1036@dideu.com
Country
China
ProdList
7619
Advantage
58
Guangzhou Squirrel Biotechnology Co., Ltd.
Tel
17765276361
Country
CHINA
ProdList
109
Advantage
58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6208
Advantage
58
Proteintech China
Tel
--
Fax
--
Email
Proteintech-CN@ptglab.com
Country
CHINA
ProdList
6290
Advantage
58
More
Less

View Lastest Price from 3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCL manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
Acoramidis hydrochloride 2242751-53-5
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-05-17
Shaanxi Dideu New Materials Co. Ltd
Product
3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCL 2242751-53-5
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-05-16

2242751-53-5, 3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCLRelated Search:


  • 3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid HCL
  • Acoramidis hydrochloride
  • AG10 hydrochloride
  • 3-(3-(3,5-Dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid hydrochloride
  • Acoramidis?hydrochloride?(AG10 hydrochloride)
  • Acoramidis hydrochloride, 10 mM in DMSO
  • 2242751-53-5
  • 3-(3-(3,5-DIMET