BENZO[B]THIOPHENE-2-CARBONYL CHLORIDE

BENZO[B]THIOPHENE-2-CARBONYL CHLORIDE Property

Melting point:

85-86°C

Boiling point:

176°C/17mmHg(lit.)

Density 

1.410±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

powder to crystal

color 

White to Orange to Green

Sensitive 

Moisture Sensitive

BRN 

125174

CAS DataBase Reference

39827-11-7(CAS DataBase Reference)

Safety

Hazard Codes 

C,Xi

Risk Statements 

34-36

Safety Statements 

26-36/37/39

RIDADR 

3261

Hazard Note 

Corrosive

HazardClass 

8

PackingGroup 

III

HS Code 

2934999090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

BENZO[B]THIOPHENE-2-CARBONYL CHLORIDE Chemical Properties,Usage,Production

Synthesis

The general procedure for the synthesis of benz[b]thiophene-2-carboxylic acid from benz[b]thiophene-2-carboxylic acid was as follows: benz[b]thiophene-2-carboxylic acid (356.42 mg, 2 mmol) was suspended in anhydrous toluene (6 mL) and thionyl chloride (4.4 mL, 60 mmol) and N,N-dimethylformamide (DMF, 0.05 mL) were added. After stirring at room temperature, the mixture was heated to reflux for 8 hours. Upon completion of the reaction, the volatiles were removed under reduced pressure to afford benzo[b]thiophene-2-carbonyl chloride as a yellow powder. Purification by rapid chromatography on silica gel using ethyl acetate/hexane (1:9, v/v) as eluent gave the target product (393.64 mg, 94.9% yield) as a white powder. The spectral data of the product were in agreement with those reported in the literature.1H NMR (300 MHz, CDCl3): δ 8.31 (s, 1H), 7.04-7.89 (m, 2H), 7.60-7.46 (m, 2H); 13C NMR (300 MHz, CDCl3): δ 161.14, 144.07, 138.05, 136.59, 135.89, 128.75, 126.68, 125.66, 122.91.

References

[1] Journal of the American Chemical Society, 2011, vol. 133, # 11, p. 3764 - 3767
[2] Patent: WO2012/99785, 2012, A2. Location in patent: Page/Page column 25
[3] Tetrahedron Asymmetry, 2003, vol. 14, # 3, p. 339 - 346
[4] Organometallics, 2015, vol. 34, # 12, p. 3065 - 3071
[5] Journal of the American Chemical Society, 2005, vol. 127, # 43, p. 15010 - 15011