ChemicalBook > CAS DataBase List > AB 680)

AB 680)

Product Name: AB 680)
CAS No.: 2105904-82-1
Chemical Name: AB 680)
Synonyms: CD73 inhibitor AB-680;AB 680);AB680 ，S8908;AB680 (AB-680;AB-680, 10 mM in DMSO;Inhibitor,AB680,CD73,inhibit,AB 680,AB-680;1H-Pyrazolo[3,4-b]pyridin-4-amine, 6-chloro-N-[(1S)-1-(2-fluorophenyl)ethyl]-1-[5-O-[hydroxy(phosphonomethyl)phosphinyl]-β-D-ribofuranosyl]-;(((((2R,3S,4R,5R)-5-(6-Chloro-4-(((S)-1-(2-fluorophenyl)ethyl)amino)-1H-pyrazolo[3,4-b]pyridin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)methyl)phosphonic acid
CBNumber: CB94844429
Molecular Formula: C20H24ClFN4O9P2
Formula Weight: 580.83
MOL File: 2105904-82-1.mol

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AB 680) Property

Boiling point:: 867.0±75.0 °C(Predicted)
Density: 1.86±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C, stored under nitrogen
solubility: DMSO : 200 mg/mL (344.34 mM; Need ultrasonic)
pka: 1.62±0.10(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0090231
Product name: AB-680
Purity: 99.71%
Packaging: 1mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0090231
Product name: AB-680
Purity: 99.71%
Packaging: 5mg
Price: $980
Updated: 2021/12/16

ChemScene

Product number: CS-0090231
Product name: AB-680
Purity: 99.71%
Packaging: 10mg
Price: $1500
Updated: 2021/12/16

DC Chemicals

Product number: DC21981
Product name: CD73inhibitorAB-680
Purity: >98%
Packaging: 1g
Price: $3900
Updated: 2021/12/16

DC Chemicals

Product number: DC21981
Product name: CD73inhibitorAB-680
Purity: >98%
Packaging: 100mg
Price: $950
Updated: 2021/12/16

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AB 680) Chemical Properties,Usage,Production

Uses

AB-680 is a highly potent, reversible and selective inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity[1].

References

[1] Lawson KV, et al. Discovery and Characterization of AB680, a Potent and Selective Small-Molecule CD73 Inhibitor for Cancer Immunotherapy.

AB 680) Preparation Products And Raw materials

Raw materials

Preparation Products

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AB 680) Suppliers

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2105904-82-1, AB 680)Related Search:

AB 680)

AB680 (AB-680

Inhibitor,AB680,CD73,inhibit,AB 680,AB-680

1H-Pyrazolo[3,4-b]pyridin-4-amine, 6-chloro-N-[(1S)-1-(2-fluorophenyl)ethyl]-1-[5-O-[hydroxy(phosphonomethyl)phosphinyl]-β-D-ribofuranosyl]-

(((((2R,3S,4R,5R)-5-(6-Chloro-4-(((S)-1-(2-fluorophenyl)ethyl)amino)-1H-pyrazolo[3,4-b]pyridin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)methyl)phosphonic acid

AB-680, 10 mM in DMSO

CD73 inhibitor AB-680

AB680 ，S8908

2105904-82-1