AC-4-130

Product Name: AC-4-130
CAS No.: 1834571-82-2
Chemical Name: AC-4-130
Synonyms: AC-4-130;AC4130,AC 4 130;Benzoic acid, 4-[[[3,5-bis(1,1-dimethylethyl)phenyl]methyl][2-[[(4-chlorophenyl)methyl][(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-
CBNumber: CB94844434
Molecular Formula: C37H36ClF5N2O5S
Formula Weight: 751.2
MOL File: 1834571-82-2.mol

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AC-4-130 Property

Boiling point:: 756.3±70.0 °C(Predicted)
Density: 1.362±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
pka: 4.28±0.10(Predicted)
form: Solid
color: Off-white to brown

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Hazard and Precautionary Statements (GHS)

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AC-4-130 Chemical Properties,Usage,Production

Biological Activity

AC-4-130 is a potent STAT5 SH2 domain inhibitor. AC-4-130 directly binds to STAT5 and disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription. AC-4-130 induces cell cycle arrest and apoptosis in FLT3-ITD-driven leukemic cells. AC-4-130 has anti-cancer activity and can efficiently block pathological levels of STAT5 activity in acute myeloid leukemia (AML)[1]. AC-4-130 (0.1-100 μM; 72 hours) leads to a significant increase in apoptosis in a dose-dependent and time-dependent manner in MV4-11 or MOLM-13 cells[1]. AC-4-130 (2, 5 μM; 72 hours) induces cell cycle arrest with an increase in G0/G1 arrested cells and a concomitant reduction in cells in S or G2/M[1]. AC-4-130 (0.5-2; 24 hours) reveals reduced pY-STAT5 levels both in the cytoplasm and nucleus[1]. AC-4-130-mediated STAT5 inhibition efficiently blocks the proliferation and clonogenic growth of primary human AML cells, while healthy CD34+ cells are less sensitive[1].

References

[1]. Bettina Wingelhofer, et al. Pharmacologic inhibition of STAT5 in acute myeloid leukemia. Leukemia. 2018 May;32(5):1135-1146.

AC-4-130 Preparation Products And Raw materials

Raw materials

Preparation Products

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AC-4-130 Suppliers

China 9 United States 2 Global 11

Shanghai EFE Biological Technology Co., Ltd.

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HANGZHOU CLAP TECHNOLOGY CO.,LTD

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TargetMol Chemicals Inc.

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Aladdin Scientific

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1834571-82-2, AC-4-130Related Search:

AC-4-130

AC4130,AC 4 130

Benzoic acid, 4-[[[3,5-bis(1,1-dimethylethyl)phenyl]methyl][2-[[(4-chlorophenyl)methyl][(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-

1834571-82-2