BJE6-106 (B106)

Product Name: BJE6-106 (B106)
CAS No.: 1564249-38-2
Chemical Name: BJE6-106 (B106)
Synonyms: B106;BJE6-106 (B106);BJE6106,BJE-6-106,BJE6 106;2H-1-Benzopyran-8-carboxaldehyde, 6-[2-(9H-carbazol-9-yl)ethyl]-2,2-dimethyl-
CBNumber: CB94844560
Molecular Formula: C26H23NO2
Formula Weight: 381.47
MOL File: 1564249-38-2.mol

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BJE6-106 (B106) Property

Boiling point:: 548.1±50.0 °C(Predicted)
Density: 1.16±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:50.0(Max Conc. mg/mL);131.07(Max Conc. mM)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Axon Medchem

Product number: Axon2981
Product name: B106-BJE6-106
Purity: 98%
Packaging: 5mg
Price: $148.5
Updated: 2021/12/16

ChemScene

Product number: CS-0068104
Product name: BJE6-106
Purity: 98.17%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0068104
Product name: BJE6-106
Purity: 98.17%
Packaging: 10mg
Price: $590
Updated: 2021/12/16

ChemScene

Product number: CS-0068104
Product name: BJE6-106
Purity: 98.17%
Packaging: 50mg
Price: $1800
Updated: 2021/12/16

ChemScene

Product number: CS-0068104
Product name: BJE6-106
Purity: 98.17%
Packaging: 100mg
Price: $2800
Updated: 2021/12/16

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BJE6-106 (B106) Chemical Properties,Usage,Production

Biological Activity

BJE6-106 (B106) is a potent and selective PKCδ inhibitor with IC50 value of 0.05 μM, BJE6-106 (B106) targets PKCδ 1000-fold more selective than the PKC isoenzyme PKCα (IC50=50 μM) . BJE6-106 (B106) induces apoptosis in caspase-dependent cells. BJE6-106 (B106) has tumor-specific effects.

in vitro

BJE6-106 (B106) (0.2 μM, 0.5 μM; 24-72 hours) suppresses cell survival in melanoma cell lines with NRAS mutations. BJE6-106 (B106) (0.2 μM, 0.5 μM; 6- 24 hours) triggers caspase-dependent apoptosis, increases the activity of caspase 3/7, the effect of B106 is greater than rottlerin (10-fold) in SBcl2 cells. BJE6-106 (B106) (0.5 μM; 2-10 hours) activates the MKK4-JNK-H2AX Pathway by inducing MKK4, JNK and H2AX activation at different times in SBcl2 cells.

Cell Viability Assay

Cell Line:	Melanoma cell lines with NRAS mutations: SBcl2, FM6, SKMEL2, WM1366, WM1361A, and WM852 cells
Concentration:	0.2 μM, 0.5 μM
Incubation Time:	24 hours, 48 hours, or 72 hours
Result:	Inhibited cell survival in melanoma cell lines.

Apoptosis Analysis

< td class="col2"> SBcl2 cells

Cell Line:
Concentration:	0.2 μM, 0.5 μM
Incubation Time:	6 hours, 12 hours, or 24 hours
Result:	Induced caspase 3/7 activation.

Western Blot Analysis

< /tr> Result:

Cell Line :	SBcl2 cells
Concentration:	0.2 μM , 0.5 μM
Incubation Time:	2 hours, 5 hours, 10 hours
Increased phosphorylation of MKK4, JNK and H2AX.

target

PKCδ

0.05 μM (IC ₅₀ )

PKCα

50 μM (IC ₅₀ )

BJE6-106 (B106) Preparation Products And Raw materials

Raw materials

Preparation Products

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BJE6-106 (B106) Suppliers

China 12 United States 4 Global 16

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7787
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9804
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Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
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Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
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HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
ProdList: 6312
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
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Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29774
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
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Shanghai Yiyan Biotechnology Co. , Ltd.

Tel: 021-69985186 13611928337
Email: 3427709316@qq.com
Country: China
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1564249-38-2, BJE6-106 (B106)Related Search:

BJE6-106 (B106)

B106

BJE6106,BJE-6-106,BJE6 106

2H-1-Benzopyran-8-carboxaldehyde, 6-[2-(9H-carbazol-9-yl)ethyl]-2,2-dimethyl-

1564249-38-2