endo-BCN-PEG8-acid

Product Name: endo-BCN-PEG8-acid
CAS No.: 2126805-02-3
Chemical Name: endo-BCN-PEG8-acid
Synonyms: endo-BCN-PEG8-acid
CBNumber: CB94849590
Molecular Formula: C30H51NO12
Formula Weight: 617.73
MOL File: 2126805-02-3.mol

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endo-BCN-PEG8-acid Property

Boiling point:: 714.5±60.0 °C(Predicted)
Density: 1.19±0.1 g/cm3(Predicted)
pka: 4.28±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-23768
Product name: endo-BCN-PEG8-acid
Purity: 98%
Packaging: 25mg
Price: $380
Updated: 2021/12/16

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endo-BCN-PEG8-acid Chemical Properties,Usage,Production

Description

endo-BCN-PEG8-acid is a BCN-containing crosslinker reagent. The terminal carboxylic acid is reactive with primary amine groups in the presence of activators (e.g. EDC, or HATU). The BCN group enable copper free click chemistry with azide -tagged biomolecules. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

endo-BCN-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. endo-BCN-PEG8-acid is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

endo-BCN-PEG8-acid Preparation Products And Raw materials

Raw materials

Preparation Products

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endo-BCN-PEG8-acid Suppliers

China 11 United States 4 Global 15

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

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TargetMol Chemicals Inc.

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2126805-02-3, endo-BCN-PEG8-acidRelated Search:

endo-BCN-PEG8-NHS ester endo-BCN-PEG12-NHS ester endo-BCN-PEG12-acid

endo-BCN-PEG8-acid

2126805-02-3