endo-BCN-PEG8-acid
- Product Name
- endo-BCN-PEG8-acid
- CAS No.
- 2126805-02-3
- Chemical Name
- endo-BCN-PEG8-acid
- Synonyms
- endo-BCN-PEG8-acid
- CBNumber
- CB94849590
- Molecular Formula
- C30H51NO12
- Formula Weight
- 617.73
- MOL File
- 2126805-02-3.mol
endo-BCN-PEG8-acid Property
- Boiling point:
- 714.5±60.0 °C(Predicted)
- Density
- 1.19±0.1 g/cm3(Predicted)
- pka
- 4.28±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- BP-23768
- Product name
- endo-BCN-PEG8-acid
- Purity
- 98%
- Packaging
- 25mg
- Price
- $380
- Updated
- 2021/12/16
endo-BCN-PEG8-acid Chemical Properties,Usage,Production
Description
endo-BCN-PEG8-acid is a BCN-containing crosslinker reagent. The terminal carboxylic acid is reactive with primary amine groups in the presence of activators (e.g. EDC, or HATU). The BCN group enable copper free click chemistry with azide -tagged biomolecules. The hydrophilic PEG spacer increases solubility in aqueous media.
Uses
endo-BCN-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. endo-BCN-PEG8-acid is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
endo-BCN-PEG8-acid Preparation Products And Raw materials
Raw materials
Preparation Products
endo-BCN-PEG8-acid Suppliers
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