DMX-5084

Product Name: DMX-5084
CAS No.: 2306178-56-1
Chemical Name: DMX-5084
Synonyms: DMX-5084;DMX-5084 ，S0268;DMX-5804, 10 mM in DMSO;5-(4-(2-Methoxyethoxy)phenyl)-7-phenyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one;inhibit,DMX-5804,Inhibitor,DMX5804,MAP4K,DMX 5804,MAPK Kinase Kinase Kinase;4H-Pyrrolo[2,3-d]pyrimidin-4-one, 3,7-dihydro-5-[4-(2-methoxyethoxy)phenyl]-7-phenyl-
CBNumber: CB94866454
Molecular Formula: C21H19N3O3
Formula Weight: 361.39
MOL File: 2306178-56-1.mol

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DMX-5084 Property

storage temp.: Store at -20°C
solubility: DMSO : 125 mg/mL (345.89 mM; Need ultrasonic)
form: Solid
color: Off-white to yellow

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0090763
Product name: DMX-5804
Purity: 99.90%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0090763
Product name: DMX-5804
Purity: 99.90%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0090763
Product name: DMX-5804
Purity: 99.90%
Packaging: 50mg
Price: $1650
Updated: 2021/12/16

ChemScene

Product number: CS-0090763
Product name: DMX-5804
Purity: 99.90%
Packaging: 100mg
Price: $2650
Updated: 2021/12/16

DC Chemicals

Product number: DC22307
Product name: DMX-5804
Purity: >98%
Packaging: 1g
Price: $1800
Updated: 2021/12/16

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DMX-5084 Chemical Properties,Usage,Production

Uses

DMX-5804 is a potent, orally active and selective MAP4K4 inhibitor, with an IC50 of 3 nM, a pIC50 of 8.55 for human MAP4K4, less potent on MINK1/MAP4K6 (pIC50, 8.18), and TNIK/MAP4K7 (pIC50, 7.96). DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice[1].

IC 50

MAP4K4: 3 nM (IC₅₀); MAP4K4: 8.55 (pIC₅₀); MINK1/MAP4K6: 8.18 (pIC₅₀); TNIK/MAP4K7: 7.96 (pIC₅₀); GCK/MAP4K2: 6.50 (pIC₅₀); KHS/MAP4K5: 6.36 (pIC₅₀); GLK/MAP4K3: 4.95 (pIC₅₀); MLK1/MAP3K9: 7.19 (pIC₅₀); MLK3/MAP3K11: 6.99 (pIC₅₀); NUAK: 6.88 (pIC₅₀); VEGFR: 5.72 (pIC₅₀); ABL1: 5.80 (pIC₅₀); Aurora B: 5.49 (pIC₅₀); FLT3: 5.31 (pIC₅₀); GSK3β: 4.66 (pIC₅₀)

References

[1] Fiedler LR, et al. MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo. Cell Stem Cell. 2019 Mar 1. pii: S1934-5909(19)30013-X. DOI:10.1016/j.stem.2019.01.013

DMX-5084 Preparation Products And Raw materials

Raw materials

Preparation Products

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2306178-56-1, DMX-5084Related Search:

Dimethyl sulfide

DMX-5084

4H-Pyrrolo[2,3-d]pyrimidin-4-one, 3,7-dihydro-5-[4-(2-methoxyethoxy)phenyl]-7-phenyl-

inhibit,DMX-5804,Inhibitor,DMX5804,MAP4K,DMX 5804,MAPK Kinase Kinase Kinase

5-(4-(2-Methoxyethoxy)phenyl)-7-phenyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one

DMX-5804, 10 mM in DMSO

DMX-5084 ，S0268

2306178-56-1