L-CYCLOSERINE Property

Melting point:

147 °C

Boiling point:

191.38°C (rough estimate)

Density 

1.278

refractive index 

1.5110 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Store in freezer, under -20°C

solubility 

H2O: soluble50mg/mg protein

form 

White to off-white powder.

pka

14.36±0.40(Predicted)

color 

White to Off-White

BRN 

80799

CAS DataBase Reference

339-72-0(CAS DataBase Reference)

Safety

Hazard Codes 

Xn

Risk Statements 

5-20

Safety Statements 

38-36/37

WGK Germany 

2

RTECS 

NY2976000

F 

10

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

L-CYCLOSERINE Chemical Properties,Usage,Production

Chemical Properties

WHITE GRANULAR POWDER

Uses

antibacterial, coccidiostat

Uses

L-Cycloserine is an irreversible inhibitor of 3-ketodihydrosphingosine synthetase.

Definition

ChEBI: A 4-amino-1,2-oxazolidin-3-one that has S configuration. An antibiotic isolated from Erwinia uredovora.

Biochem/physiol Actions

L-cycloserine is a potent inhibitor of serine palmitoyltransferase, the first step of sphingolipid synthesis.

Purification Methods

Purify cycloserine by recrystallisation from aqueous EtOH or MeOH or aqueous NH3/EtOH or isoPrOH. Also recrystallise it from aqueous ammoniacal solution at pH 10.5 (100mg/mL) by diluting with 5 volumes of isopropanol and then adjusting to pH 6 with acetic acid. An aqueous solution, buffered to pH 10 with Na2CO3, can be stored in a refrigerator for 1week without decomposition. UV: max at 226nm (A1cm 1% 4.02). The tartrate salt has m 165-166o (dec), 166-168o (dec), and [] D 24 -41o (c 0.7, H2O). [Stammer et al. J Am Chem Soc 79 3236 1959, UV: Kuehl J Am Chem Soc 77 2344 1955, Beilstein 27 III/IV 5549.]