MRTX-849

ChemicalBook > CAS DataBase List > MRTX-849

Product Name: MRTX-849
CAS No.: 2326521-71-3
Chemical Name: MRTX-849
Synonyms: Adagrasib;2-((S)-4-(7-(8-chloronaphthalen-1-yl)-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-1-(2-fluoroacryloyl)piperazin-2-yl)acetonitrile;MRTX-849;Adagrasib/MRTX-849;MRTX849(Adagrasib);Azvudine Impurity 23;MRTX849;MRTX-849;MRTX 849;4-[7-(8-CHLORO-1-NAPHTHALENYL)-5,6,7,8-TETRAHYDRO-2-[[(2S)-1-METHYL-2-PYRR;2-PIPERAZINEACETONITRILE, 4-[7-(8-CHLORO-1-NAPHTHALENYL)-5,6,7,8-TETRAHYDRO-2-[[(2S)-1-METHYL-2-PYRR;2-PIPERAZINEACETONITRILE,4-[7-(8-CHLORO-1-NAPHTHALENYL)-5,Chemicalbook6,7,8-TETRAHYDRO-2-[[(2S)-1-METHYL-2-PYRR
CBNumber: CB94918285
Molecular Formula: C32H35ClFN7O2
Formula Weight: 604.12
MOL File: 2326521-71-3.mol

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MRTX-849 Property

Boiling point:: 860.2±75.0 °C(Predicted)
Density: 1.295±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO:1.0(Max Conc. mg/mL);1.7(Max Conc. mM)
form: A crystalline solid
pka: 9.31±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0105265
Product name: MRTX849
Purity: 99.72%
Packaging: 10mg
Price: $115
Updated: 2021/12/16

ChemScene

Product number: CS-0105265
Product name: MRTX849
Purity: 99.72%
Packaging: 25mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0105265
Product name: MRTX849
Purity: 99.72%
Packaging: 50mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0105265
Product name: MRTX849
Purity: 99.72%
Packaging: 100mg
Price: $680
Updated: 2021/12/16

ChemScene

Product number: CS-0105265
Product name: MRTX849
Purity: 99.72%
Packaging: 500mg
Price: $2150
Updated: 2021/12/16

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MRTX-849 Chemical Properties,Usage,Production

Uses

MRTX 849 is used as combination therapy for treatment of cancer.

brand name

Krazati

General Description

Class: non-kinase; Treatment: KRAS(G12C) NSCLC; Other name: MRTX849; Elimination half-life: 24 h; Protein binding = 98.3%

Mechanism of action

Adagrasib selectively modified mutant cysteine 12 in GDP-bound G12C and inhibited KRASdependent signaling.

Clinical Use

Adagrasib is an irreversible inhibitor of the RAS GTPase family. It is approved by the FDA for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) who have been identified by testing as having a KRAS (G12C) mutation.

target

Primary target: KRAS(G12C)

storage

Store at -20°C

MRTX-849 Preparation Products And Raw materials

Raw materials

Preparation Products

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MRTX-849 Suppliers

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View Lastest Price from MRTX-849 manufacturers

Anhui Zhongda Biotechnology Co., Ltd

Product: MRTX-849 2326521-71-3
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 100000tons
Release date: 2023-08-10

Anhui Ruihan Technology Co., Ltd

Product: MRTX-849 2326521-71-3
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000tons
Release date: 2023-08-18

Shandong Huisheng Import & Export Co., Ltd.

Product: MRTX-849 2326521-71-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%~99%
Supply Ability: 20 T each week
Release date: 2023-08-12

2326521-71-3, MRTX-849Related Search:

MRTX0902 MRTX1133 MRTX-1719 INDEX NAME NOT YET ASSIGNED MRTX-EX185

MRTX-849

MRTX849;MRTX-849;MRTX 849

2-PIPERAZINEACETONITRILE, 4-[7-(8-CHLORO-1-NAPHTHALENYL)-5,6,7,8-TETRAHYDRO-2-[[(2S)-1-METHYL-2-PYRR

2-Piperazineacetonitrile, 4-[7-(8-chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-, (2S)-

2-((S)-4-(7-(8-chloronaphthalen-1-yl)-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-1-(2-fluoroacryloyl)piperazin-2-yl)acetonitrile

2-[(2S)-4-[7-(8-chloronaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoroprop-2-enoyl)piperazin-2-yl]acetonitrile

MRTX849(Adagrasib)

Adagrasib/MRTX-849

Adagrasib

4-[7-(8-CHLORO-1-NAPHTHALENYL)-5,6,7,8-TETRAHYDRO-2-[[(2S)-1-METHYL-2-PYRR

inhibit,GDP-bound,mutant,MIA PaCa-2,MRTX-849,Adagrasib,selective,Inhibitor,MRTX 849,inactive,state,G12C,H1373,covalent,anti-tumor,KRAS,Ras,cells

2-PIPERAZINEACETONITRILE,4-[7-(8-CHLORO-1-NAPHTHALENYL)-5,Chemicalbook6,7,8-TETRAHYDRO-2-[[(2S)-1-METHYL-2-PYRR

2-[(S)-4-[7-(8-chloro-1-naphthyl)-2-[[(S)-1-methyl-2-pyrrolidinyl]methoxy]-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoroacryloyl)-2-piperazinyl]acetonitrile

Azvudine Impurity 23

2326521-71-3

api

2326521-71-3