4-AMINO-N-(2-PHENYLETHYL)BENZENESULFONAMIDE

ChemicalBook > CAS DataBase List > 4-AMINO-N-(2-PHENYLETHYL)BENZENESULFONAMIDE

4-AMINO-N-(2-PHENYLETHYL)BENZENESULFONAMIDE

Product Name: 4-AMINO-N-(2-PHENYLETHYL)BENZENESULFONAMIDE
CAS No.: 587850-67-7
Chemical Name: 4-AMINO-N-(2-PHENYLETHYL)BENZENESULFONAMIDE
Synonyms: CS-1909;C7280948;AKOS BBB/007;C7280948, >98%;ASISCHEM B51558;C 7280948;C-7280948;C 7280948, PRMT1 inhibitor;4-AMINO-N-PHENETHYL-BENZENESULFONAMIDE;4-AMINO-N-(2-PHENYLETHYL)BENZENESULFONAMIDE;Benzenesulfonamide, 4-amino-N-(2-phenylethyl)-
CBNumber: CB9493764
Molecular Formula: C14H16N2O2S
Formula Weight: 276.35
MOL File: Mol file

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4-AMINO-N-(2-PHENYLETHYL)BENZENESULFONAMIDE Property

Melting point:: 143℃
Boiling point:: 481.1±55.0 °C(Predicted)
Density: 1.258±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: insoluble in H2O; insoluble in EtOH; ≥13.9 mg/mL in DMSO
form: solid
pka: 12.47±0.50(Predicted)
color: White to off-white

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21601
Product name: C-7280948
Purity: ≥98%
Packaging: 100mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 21601
Product name: C-7280948
Purity: ≥98%
Packaging: 250mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 21601
Product name: C-7280948
Purity: ≥98%
Packaging: 500mg
Price: $324
Updated: 2024/03/01

Cayman Chemical

Product number: 21601
Product name: C-7280948
Purity: ≥98%
Packaging: 1g
Price: $575
Updated: 2024/03/01

ApexBio Technology

Product number: B5913
Product name: C7280948
Packaging: 10mM(in 1mL DMSO)
Price: $50
Updated: 2021/12/16

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4-AMINO-N-(2-PHENYLETHYL)BENZENESULFONAMIDE Chemical Properties,Usage,Production

Biological Activity

c7280948 is a novel prmt1 inhibitor with ic50 value of 12.75 μm [1].protein arginine methyltransferase 1 (prmt1) is a histone methyltransferase specific for histone h4. prmt1 catalyzes the transfer of the methyl group from sam to the guanidine nitrogen atoms of arginine residues to produce monomethyl arginines (mma) and asymmetric dimethyl arginines (adma) [2].c7280948 is a novel prmt1 inhibitor. c7280948 interacts with aromatic residues at the hprmt1 substrate binding pocket (tyr 147 and tyr 160) [1]. c7280948 inhibited hprmt1 with ic50 value of 26.7 μm [3].

References

[1]. heinke r, spannhoff a, meier r, et al. virtual screening and biological characterization of novel histone arginine methyltransferase prmt1 inhibitors. chemmedchem, 2009, 4(1): 69-77.
[2]. itoh y, suzuki t, miyata n. small-molecular modulators of cancer-associated epigenetic mechanisms. mol biosyst, 2013, 9(5): 873-896.
[3]. bissinger em, heinke r, spannhoff a, et al. acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hprmt1. bioorg med chem, 2011, 19(12): 3717-3731.

4-AMINO-N-(2-PHENYLETHYL)BENZENESULFONAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-AMINO-N-(2-PHENYLETHYL)BENZENESULFONAMIDE Suppliers

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View Lastest Price from 4-AMINO-N-(2-PHENYLETHYL)BENZENESULFONAMIDE manufacturers

Career Henan Chemical Co

Product: 4-AMINO-N-(2-PHENYLETHYL)BENZENESULFONAMIDE 587850-67-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%~99%
Supply Ability: per week:100kg
Release date: 2019-09-05

587850-67-7, 4-AMINO-N-(2-PHENYLETHYL)BENZENESULFONAMIDERelated Search:

C7280948, >98%

CS-1909

C 7280948;C-7280948

C7280948

ASISCHEM B51558

4-AMINO-N-PHENETHYL-BENZENESULFONAMIDE

4-AMINO-N-(2-PHENYLETHYL)BENZENESULFONAMIDE

AKOS BBB/007

4-Amino-N-(2-phenylethyl)benzenesulfonamide C 7280948

Benzenesulfonamide, 4-amino-N-(2-phenylethyl)-

C 7280948, PRMT1 inhibitor

587850-67-7

Inhibitors