4,5-DIMETHYL-1,3-THIAZOL-2-AMINE

Product Name: 4,5-DIMETHYL-1,3-THIAZOL-2-AMINE
CAS No.: 2289-75-0
Chemical Name: 4,5-DIMETHYL-1,3-THIAZOL-2-AMINE
Synonyms: AURORA 5329;ASISCHEM D48929;AKOS BBS-00004664;IFLAB-BB F1920-0013;4,5-DIMETHYLTHIAZOL-2-AMINE;white to light yellow solid;DIMETHYL-1,3-THIAZOL-2-AMINE;2-ThiazolaMine,4,5-diMethyl-;4,5-DIMETHYL-THIAZOL-2-YLAMINE;4,5-dimethyl-1,3-thiazol-2-amin
CBNumber: CB9494620
Molecular Formula: C5H8N2S
Formula Weight: 128.2
MOL File: 2289-75-0.mol

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4,5-DIMETHYL-1,3-THIAZOL-2-AMINE Property

Melting point:: 66-69
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: crystalline solid
color: Very dark red/ brown
CAS DataBase Reference: 2289-75-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22
HazardClass: IRRITANT
HS Code: 2934100090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2916
Product name: 4,5-Dimethylthiazol-2-amine
Packaging: 1G
Price: $54
Updated: 2025/07/31

TCI Chemical

Product number: A2916
Product name: 4,5-Dimethylthiazol-2-amine
Packaging: 5G
Price: $162
Updated: 2025/07/31

TRC

Product number: D462355
Product name: 4,5-Dimethyl-1,3-thiazol-2-amine
Packaging: 500mg
Price: $65
Updated: 2021/12/16

ChemScene

Product number: CS-W018469
Product name: 4,5-Dimethylthiazol-2-amine
Purity: >97.0%
Packaging: 5g
Price: $78
Updated: 2021/12/16

Matrix Scientific

Product number: 046865
Product name: 4,5-Dimethyl-1,3-thiazol-2-amine
Purity: >95%
Packaging: 500mg
Price: $25
Updated: 2021/12/16

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4,5-DIMETHYL-1,3-THIAZOL-2-AMINE Chemical Properties,Usage,Production

Synthesis

4091-39-8

17356-08-0

2289-75-0

1. In a 250 mL three-necked round-bottomed flask equipped with a stirrer, condenser tube, and constant-pressure dropping funnel, 43.27 g (0.6 mol) of 3-chloro-2-butanone and 30.42 g (0.3 mol) of 36% hydrochloric acid were added. Subsequently, 8.1 g (0.06 mol) of copper chloride was added and the reaction system was warmed to 35°C. 49.23 g (0.39 mol) of 30% hydrogen peroxide was added slowly and dropwise over a period of 15 minutes. After the dropwise addition was completed, the reaction mixture was heated to 78°C and refluxed for 5 hours. After completion of the reaction, it was cooled to room temperature, the organic phase was separated, washed twice sequentially with saturated sodium carbonate solution and dried over anhydrous sodium sulfate. The 137-140°C fraction was collected by decompression distillation to give 8.0 g of 3-chloro-2-butanone derivative XVII in 12.6% yield. 2. 30 mL of ethanol and 3.5 g (47 mmol) of thiourea were added to a 100 mL round-bottomed flask and heated to reflux with stirring until the thiourea was completely dissolved. Subsequently, 5.0 g (47 mmol) of 3-chloro-2-butanone derivative XVII was added and refluxing was continued overnight. After completion of the reaction, the ethanol was removed by concentration under reduced pressure. The crude product obtained was dissolved in 30 mL of dichloromethane, washed with saturated sodium carbonate solution, the organic layer was separated and dried over anhydrous sodium sulfate. After concentration, a yellow oil was obtained, which was further processed to give 2-amino-4,5-dimethylthiazole XVIII 3.8 g in 63.3% yield.

References

[1] Patent: CN102942565, 2016, B. Location in patent: Paragraph 0040-0043; 0093-0094
[2] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1965, vol. 1, p. 200 - 201
[3] Khimiya Geterotsiklicheskikh Soedinenii, 1965, vol. 1, p. 303 - 305
[4] Russian Journal of Organic Chemistry, 2013, vol. 49, # 4, p. 575 - 579
[5] Zh. Org. Khim., 2013, vol. 49, # 4, p. 591 - 595,5

4,5-DIMETHYL-1,3-THIAZOL-2-AMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4,5-DIMETHYL-1,3-THIAZOL-2-AMINE Suppliers

Austria 1 Canada 1 China 86 Germany 3 India 1 Ukraine 2 United Kingdom 5 United States 13 Global 112

Meryer (Shanghai) Chemical Technology Co., Ltd.

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View Lastest Price from 4,5-DIMETHYL-1,3-THIAZOL-2-AMINE manufacturers

Career Henan Chemical Co

Product: 4,5-DIMETHYL-1,3-THIAZOL-2-AMINE 2289-75-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2019-08-07

2289-75-0, 4,5-DIMETHYL-1,3-THIAZOL-2-AMINERelated Search:

Ethyl 2-amino-4-methylthiazole-5-carboxylate 4,5-DIMETHYL-1,3-THIAZOL-2-AMINE HYDROBROMIDE 2-AMINO-4,5-DIMETHYLTHIAZOLE HYDROCHLORIDE 2-AMINO-4-PHENYL-5-N-TETRADECYLTHIAZOLE 2-Amino-4-methyl-5-acetylthiazole 2-Amino-5,6-dihydro-4H-cyclopentathiazole hydrochloride MTT Ethyl 2-amino-4-phenyl-5-thiazolecarboxylate 4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-2-YLAMINE MTT FORMAZAN 1-(4-METHYL-2-PHENYLAMINO-THIAZOL-5-YL)-ETHANONE 4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-2-YLAMINE HYDROCHLORIDE 1-(3-((2-CHLOROPHENYL)AMINO)-5-METHYL-2,4-THIAZOLYL)ETHAN-1-ONE (2,4-DICHLOROPHENYL)(3-((HYDROXYIMINO)ETHYL)-4-METHYL(2,5-THIAZOLYL))AMINE N-(4-(((3-ACETYL-4-METHYL-2,5-THIAZOLYL)AMINO)SULFONYL)PHENYL)ETHANAMIDE (2-CHLOROPHENYL)(3-((HYDROXYIMINO)ETHYL)-4-METHYL(2,5-THIAZOLYL))AMINE (3-((HYDROXYIMINO)ETHYL)-4-METHYL(2,5-THIAZOLYL))(3-(TRIFLUOROMETHYL)PHENYL)AMINE N-(3-ACETYL-4-METHYL(2,5-THIAZOLYL))-2,2,2-TRIFLUOROETHANAMIDE

2-Amino-4,5-dimethyl-1,3-thiazole 95%

DIMETHYL-1,3-THIAZOL-2-AMINE

IFLAB-BB F1920-0013

AURORA 5329

ASISCHEM D48929

AKOS BBS-00004664

4,5-DIMETHYL-THIAZOL-2-YLAMINE

4,5-DIMETHYL-1,3-THIAZOL-2-AMINE

2-Amino-4,5-dimethyl-1,3-thiazole

4,5-DIMETHYLTHIAZOL-2-AMINE

4,5-dimethyl-1,3-thiazol-2-amine(SALTDATA: HCl)

white to light yellow solid

2-ThiazolaMine,4,5-diMethyl-

4,5-Dimethyl-2-Thiazolamine 4,5-Dimethyl-1,3-Thiazol-2-Amine(SALTDATA: Hcl)

4,5-dimethyl-1,3-thiazol-2-amin

2289-75-0

pharmaceutical intermediate

amine