4-BROMO-BENZOTHIAZOL-5-YLAMINE
- Product Name
- 4-BROMO-BENZOTHIAZOL-5-YLAMINE
- CAS No.
- 769-19-7
- Chemical Name
- 4-BROMO-BENZOTHIAZOL-5-YLAMINE
- Synonyms
- 5-Benzothiazolamine, 4-bromo-;5-AMINO-4-BROMO-BENZOTHIAZOLE;4-BROMO-BENZOTHIAZOL-5-YLAMINE;4-BroMobenzo[d]thiazol-5-aMine;4-broMo-1,3-benzothiazol-5-aMine;5-Amino-4-bromo-1,3-benzothiazole;4-Bromo-1,3-benzothiazol-5-ylamine
- CBNumber
- CB9496073
- Molecular Formula
- C7H5BrN2S
- Formula Weight
- 229.1
- MOL File
- 769-19-7.mol
4-BROMO-BENZOTHIAZOL-5-YLAMINE Property
- Melting point:
- 115 °C
- Boiling point:
- 359.3±22.0 °C(Predicted)
- Density
- 1.836±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 0.50±0.10(Predicted)
- Appearance
- Light brown to gray Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B815270
- Product name
- 4-Bromobenzo[d]thiazol-5-amine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- HCH0024346
- Product name
- 5-AMINO-4-BROMO-BENZOTHIAZOLE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $879.25
- Updated
- 2021/12/16
- Product number
- 1993AC
- Product name
- 4-Bromobenzo[d]thiazol-5-amine
- Packaging
- 250mg
- Price
- $411
- Updated
- 2021/12/16
- Product number
- HCH0024346
- Product name
- 5-AMINO-4-BROMO-BENZOTHIAZOLE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $416.85
- Updated
- 2021/12/16
- Product number
- 126566
- Product name
- 4-Bromobenzo[d]thiazol-5-amine
- Purity
- >95%
- Packaging
- 1g
- Price
- $936
- Updated
- 2021/12/16
4-BROMO-BENZOTHIAZOL-5-YLAMINE Chemical Properties,Usage,Production
Synthesis
1123-93-9
769-19-7
The general procedure for the synthesis of 5-amino-4-bromobenzothiazole from 1,3-benzothiazol-5-amine is as follows: a solution of bromine (2.3 g, 14.4 mmol) in trichloromethane (10 mL) was slowly added dropwise to a solution of benzo[d]thiazol-5-amine (2.1 g, 14.0 mmol) in trichloromethane (100 mL) at 10 °C. The reaction mixture was stirred continuously for 1 hour at room temperature. Subsequently, the reaction mixture was alkalized with saturated aqueous sodium carbonate solution (100 mL) and extracted with dichloromethane (3 x 30 mL). After combining the organic layers, they were dried with anhydrous sodium sulfate and concentrated under vacuum. The residue was purified by silica gel column chromatography (eluent ratio ethyl acetate/petroleum ether = 1:4) to give a final yellow solid 5-amino-4-bromobenzothiazole (2.3 g). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 9.01 (s, 1H), 7.66 (d, 1H), 6.95 (d, 1H), 4.33 (s, 2H).
References
[1] Journal of the Chemical Society, 1965, p. 2248 - 2250
[2] Patent: US2009/118295, 2009, A1. Location in patent: Page/Page column 23-24
[3] Patent: WO2013/142266, 2013, A1. Location in patent: Paragraph 00507
4-BROMO-BENZOTHIAZOL-5-YLAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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