SPARSOMYCIN
- Product Name
- SPARSOMYCIN
- CAS No.
- 1404-64-4
- Chemical Name
- SPARSOMYCIN
- Synonyms
- U-19183;nsc59729;Aids012106;B 120121L19;Aids-012106;sparsomycin;Sparsomycin from Streptomyces sparsogenes;(E)-N-[(S)-1-(Hydroxymethyl)-2-[[(methylthio)methyl]sulfinyl]ethyl]-3-(1,2,3,4-tetrahydro-6-methyl-2,4-dioxopyrimidine-5-yl)propenamide;2-Propenamide, N-[(1S)-1-(hydroxymethyl)-2-[(R)-[(methylthio)methyl]sulfinyl]ethyl]-3-(1,2,3,4-tetrahydro-6-methyl-2,4-dioxo-5-pyrimidinyl)-, (2E)-
- CBNumber
- CB9497025
- Molecular Formula
- C13H19N3O5S2
- Formula Weight
- 361.44
- MOL File
- 1404-64-4.mol
SPARSOMYCIN Property
- Melting point:
- 208-209° (dec)
- alpha
- D25 +69° (c = 0.5 in water)
- Density
- 1.3893 (rough estimate)
- refractive index
- 1.6390 (estimate)
- storage temp.
- 2-8°C
- solubility
- DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
- form
- A solid
- pka
- 8.67 in water, 9.05 in 40% ethanol
- color
- White to off-white
Safety
- Hazard Codes
- T+
- Risk Statements
- 28
- Safety Statements
- 28-36/37-45
- RIDADR
- UN 2811 6.1/PG 2
- RTECS
- WG5850000
- Toxicity
- LD50 in dogs, rats, mice (mg/kg): 0.5-1.0, 2.25, 4.32 i.v. (Ottenheijm, 1986); LD50 i.p. in mice: 2.4 mg/kg (Owen)
N-Bromosuccinimide Price
- Product number
- 29934
- Product name
- Sparsomycin
- Packaging
- 1mg
- Price
- $189
- Updated
- 2024/03/01
- Product number
- 29934
- Product name
- Sparsomycin
- Packaging
- 5mg
- Price
- $755
- Updated
- 2024/03/01
- Product number
- API0015533
- Product name
- SPARSOMYCIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.41
- Updated
- 2021/12/16
SPARSOMYCIN Chemical Properties,Usage,Production
Description
Sparsomycin is a bacterial metabolite and a nucleoside analog of uracil that has been found in S. sparsogenes and has diverse biological activities. It is active against KB carcinoma cells, Gram-positive and Gram-negative bacteria, and fungi. Sparsomycin is an inhibitor of peptidyl transferase that interferes with tRNA binding to the A-site of the peptidyl transfer center and increases the binding of peptidyl-tRNA to the P-site. It inhibits protein synthesis in bacteria, archaea, and eukaryotes. Sparsomycin reduces tumor growth in a P388 mouse leukemia model and in a Walker 256 carcinosarcoma rat model.
Uses
Research tool for studying protein biosynthesis.
Uses
Sparsomycin is an antibiotic that binds to active site and exit tunnel hydrophobic crevices of peptidyltransferase center of Haloarcula marismortui large ribosomal subunit.
SPARSOMYCIN Preparation Products And Raw materials
Raw materials
Preparation Products
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