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DIAZIQUONE

Product Name
DIAZIQUONE
CAS No.
57998-68-2
Chemical Name
DIAZIQUONE
Synonyms
azq;Diaziquon;nsc182986;NSC-182896;diaziquone;aziridinylquinone;aziridinylbenzoquinone;3,6-diaziridinyl-2,5-bis(carboethoxyamino)-1,4-benzoquinone;2,5-diaziridinyl-3,6-bis(carboethoxyamino)-1,4-benzoquinone;2,5-Bis(1-aziridinyl)-3,6-bis-(carbethoxyamino)-1,4-benzoquinone
CBNumber
CB9498057
Molecular Formula
C16H20N4O6
Formula Weight
364.35
MOL File
57998-68-2.mol
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DIAZIQUONE Property

Melting point:
230° (dec)
Boiling point:
495.56°C (rough estimate)
Density 
1.2204 (rough estimate)
refractive index 
1.6000 (estimate)
form 
Solid
color 
Orange needles from EtOH
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Safety

Hazard Codes 
Xn
Risk Statements 
40
Safety Statements 
22-36
RTECS 
EY8794000
Toxicity
LD50 in mice (mg/m2): 30.9 i.v. (Bender)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0011212
Product name
DIAZIQUONE
Purity
95.00%
Packaging
5MG
Price
$495.18
Updated
2021/12/16
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DIAZIQUONE Chemical Properties,Usage,Production

Uses

Antineoplastic.

Definition

ChEBI: A 1,4-benzoquinone that is substituted at positions 2 and 5 have been replaced by aziridin-1-yl groups and at positions 3 and 6 by (ethoxycarbonyl)amino groups.

Safety Profile

Poison by intravenous andintraperitoneal routes. Human mutation data reported.When heated to decomposition it emits toxic fumes ofNOx.

in vivo

Diaziquone (6.75mg /sq m daily for 5 consecutive days or single-dose 26 mg/sq m) has a broad range of activity of diaziquone against primary nervous system tumors and has enhancement effect combined with either 1,3-bis(2-chloroethyl)-1-nitrosourea or procarbazine in athymic mice[1].

Animal Model:Homozygous nu/nu BALB/c athymic mice[1]
Dosage:6.75mg /sq m or 26 mg/sq m
Administration:6.75mg /sq m daily for 5 consecutive days or single-dose 26 mg/sq m
Result:Showed rapid clearance in the plasma of athymic mice with a half-life of approximately 11.5 min.
Produced significant growth delays.
Produced significant increases in the median growth delay, significant increases in the number of tumor regressions.

DIAZIQUONE Preparation Products And Raw materials

Raw materials

Preparation Products

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DIAZIQUONE Suppliers

China 6 Switzerland 1 United States 2 Global 9
SIGMA-RBI
Tel
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Fax
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Country
Switzerland
ProdList
6896
Advantage
91

57998-68-2, DIAZIQUONERelated Search:

2,5-DIAZIRIDINYL-1,4-BENZOQUINONE 1-ethenylaziridine DIAZIQUONE 2,5-Diamino-2,5-cyclohexadiene-1,4-dione

  • aziridinylbenzoquinone
  • aziridinylquinone
  • azq
  • diaziquone
  • nsc182986
  • AZQ, 2,5-Bis(1-aziridinyl)-3,6-bis-(carbethoxyamino)-1,4-benzoquinone
  • Diaziquon
  • NSC-182896
  • (2,5-bis(1-aziridinyl)-3,6-dioxo-1,4-cyclohexadien-1,4-diyl)bis-carbamicaci
  • 2,5-diaziridinyl-3,6-bis(carboethoxyamino)-1,4-benzoquinone
  • 3,6-diaziridinyl-2,5-bis(carboethoxyamino)-1,4-benzoquinone
  • 2,5-Bis(1-aziridinyl)-3,6-bis-(carbethoxyamino)-1,4-benzoquinone
  • 4-cyclohexadiene-1,4-dicarbamicacid,2,5-bis(1-aziridinyl)-3,6-dioxo-die
  • Carbamic acid, N,N'-[2,5-bis(1-aziridinyl)-3,6-dioxo-1,4-cyclohexadiene-1,4-diyl]bis-, C,C'-diethyl ester
  • 57998-68-2
  • 7998-68-2