1-Iodo-2-naphthol

1-Iodo-2-naphthol Property

Melting point:

92-96 °C(lit.)

Boiling point:

307.0±15.0 °C(Predicted)

Density 

1.874±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

7.63±0.50(Predicted)

Appearance

Yellow to brown Solid

InChI

InChI=1S/C10H7IO/c11-10-8-4-2-1-3-7(8)5-6-9(10)12/h1-6,12H

InChIKey

JEVGGOSILOIIHN-UHFFFAOYSA-N

SMILES

C1(I)=C2C(C=CC=C2)=CC=C1O

Safety

Hazard Codes 

Xi,N

Risk Statements 

38-41-52/53

Safety Statements 

26-36/37/39-61

WGK Germany 

3

RTECS 

QL4150000

HS Code 

2907290090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

1-Iodo-2-naphthol Chemical Properties,Usage,Production

Synthesis

General procedure for the synthesis of 1-iodo-2-naphthol from 2-hydroxy-1-naphthalenecarboxylic acid: 2-hydroxy-1-naphthalenecarboxylic acid (37.6 mg, 0.2 mmol), N-iodosuccinimide (NIS, 47.3 mg, 0.21 mmol), palladium acetate (0.9 mg, 0.002 mmol), and a stirrer were added to the reaction tube. Under the protection of inert gas, 1 mL of N,N-dimethylformamide (DMF) was added to the reaction tube as a solvent, followed by sealing the reaction tube. The reaction tube was placed in an oil bath at 80°C and the reaction was stirred for 3 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature and the pH was adjusted to 10 with 2 mol/L sodium hydroxide solution.The reaction mixture was diluted with 5 mL of water and extracted with ethyl acetate (5 mL x 3). The organic phases were combined, washed with water, dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure. The crude product was purified by column chromatography using ethyl acetate and petroleum ether (0:1 to 1:30, v/v) as eluent to give pure 1-iodo-2-naphthol (33.0 mg, 61% yield).

References

[1] Patent: CN106748604, 2017, A. Location in patent: Paragraph 0067; 0068