5-CYCLOPROPYLISOXAZOLE-3-CARBOXYLIC ACI&
- Product Name
- 5-CYCLOPROPYLISOXAZOLE-3-CARBOXYLIC ACI&
- CAS No.
- 110256-15-0
- Chemical Name
- 5-CYCLOPROPYLISOXAZOLE-3-CARBOXYLIC ACI&
- Synonyms
- 5-CYCLOPROPYLISOXAZOLE-3-CARBOXYLIC ACI&;5-cyclopropyl-3-isoxazolecarboxylic acid;3-Isoxazolecarboxylicacid, 5-cyclopropyl-;3-Isoxazolecarboxylicacid,5-cyclopropyl-(9CI);5-cyclopropylisoxazole-3-carboxylic acid(SALTDATA: FREE)
- CBNumber
- CB9498835
- Molecular Formula
- C7H7NO3
- Formula Weight
- 153.14
- MOL File
- 110256-15-0.mol
5-CYCLOPROPYLISOXAZOLE-3-CARBOXYLIC ACI& Property
- Melting point:
- 96-100 °C(lit.)
- Boiling point:
- 358.1±30.0 °C(Predicted)
- Density
- 1.445
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- form
- solid
- pka
- 3.46±0.10(Predicted)
- Appearance
- Off-white to light brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 644803
- Product name
- 5-Cyclopropylisoxazole-3-carboxylic acid
- Purity
- 95%
- Packaging
- 1g
- Price
- $90.8
- Updated
- 2025/07/31
- Product number
- 644803
- Product name
- 5-Cyclopropylisoxazole-3-carboxylic acid
- Purity
- 95%
- Packaging
- 5g
- Price
- $199.5
- Updated
- 2025/07/31
- Product number
- C992025
- Product name
- 5-Cyclopropylisoxazole-3-carboxylic acid
- Packaging
- 1g
- Price
- $220
- Updated
- 2021/12/16
- Product number
- FC59699
- Product name
- 5-Cyclopropylisoxazole-3-carboxylic acid
- Packaging
- 2g
- Price
- $240
- Updated
- 2021/12/16
- Product number
- FC59699
- Product name
- 5-Cyclopropylisoxazole-3-carboxylic acid
- Packaging
- 500mg
- Price
- $100
- Updated
- 2021/12/16
5-CYCLOPROPYLISOXAZOLE-3-CARBOXYLIC ACI& Chemical Properties,Usage,Production
Uses
5-Cyclopropylisoxazole-3-carboxylic Acid is a compound that has been used in the discovery, design and synthesis of a selective S1P3 receptor allosteric agonist (N,N-Dicyclohexyl-5-propylisoxazole-3-carboxamide).
Synthesis
21080-81-9
110256-15-0
The general procedure for the synthesis of 5-cyclopropylisoxazole-3-carboxylic acid from ethyl 5-cyclopropylisoxazole-3-carboxylate was as follows:Intermediate 16 - Preparation of 5-cyclopropylisoxazole-3-carboxylic acid. A mixture of ethyl 5-cyclopropylisoxazole-3-carboxylate (0.550 g, 3.04 mmol) with 1M aqueous sodium hydroxide (9.11 mL, 9.11 mmol) was stirred at room temperature for 72 hours. Upon completion of the reaction, the pH of the reaction solution was adjusted to 1 with 6N hydrochloric acid, followed by extraction with ethyl acetate. The organic layer was separated, dried with anhydrous magnesium sulfate and concentrated under reduced pressure to give 0.446 g of 5-cyclopropylisoxazole-3-carboxylic acid as a solid in 96% yield. The product was confirmed by mass spectrometry: ESI/APCI(+) m/z: 154 (M+H), 176 (M+Na); ESI/APCI(-) m/z: 152 (M-H).
References
[1] Journal of Medicinal Chemistry, 2016, vol. 59, # 1, p. 358 - 373
[2] Patent: WO2010/142801, 2010, A1. Location in patent: Page/Page column 151
[3] Patent: US2003/236287, 2003, A1. Location in patent: Page 46, 47
[4] Patent: WO2016/40502, 2016, A1. Location in patent: Page/Page column 65
[5] Patent: WO2016/40504, 2016, A1. Location in patent: Paragraph 0194
5-CYCLOPROPYLISOXAZOLE-3-CARBOXYLIC ACI& Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-CYCLOPROPYLISOXAZOLE-3-CARBOXYLIC ACI& manufacturers
- Product
- 5-CYCLOPROPYLISOXAZOLE-3-CARBOXYLIC ACI 110256-15-0
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02