PARAMETHADIONE (500 MG)

Product Name: PARAMETHADIONE (500 MG)
CAS No.: 115-67-3
Chemical Name: PARAMETHADIONE (500 MG)
Synonyms: a348;A 348;Paradione;HSDB 3245;BRN 0127715;Isethadionum;Isoethadione;Parametadione;Paramethodione;Paramethadione
CBNumber: CB9500518
Molecular Formula: C7H11NO3
Formula Weight: 157.17
MOL File: 115-67-3.mol

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PARAMETHADIONE (500 MG) Property

Melting point:: 31-32 °C
Boiling point:: 281.82°C (rough estimate)
Density: d425 1.1180-1.1240
refractive index: nD25 1.449
pka: -2.18±0.40(Predicted)
EPA Substance Registry System: Paramethadione (115-67-3)

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Safety

Hazardous Substances Data: 115-67-3(Hazardous Substances Data)
Toxicity: LD50 orl-mus: 1000 mg/kg 27ZQAG -,280,72

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: P191830
Product name: Paramethadione
Packaging: 100mg
Price: $115
Updated: 2021/12/16

TRC

Product number: P191830
Product name: Paramethadione
Packaging: 500mg
Price: $200
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0003753
Product name: PARAMETHADIONE
Purity: 95.00%
Packaging: 100G
Price: $2458.25
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 66641
Product name: Paramethadione
Packaging: 5G
Price: $2475
Updated: 2021/12/16

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PARAMETHADIONE (500 MG) Chemical Properties,Usage,Production

Originator

Paradione,Abbott, US ,1949

Uses

Paramethadione is also used in minor forms of epilepsy.

Uses

Paramethadione acts as an antiepileptic and anticonvulsant agent.

Definition

ChEBI: Paramethadione is an oxazolidinone.

Manufacturing Process

About 143.1 grams (one mol) of 5-methyl-5-ethyloxazolidine-2,4-dione is dissolved in 300 cc of methanol containing 23 grams of sodium. To the above mixture is added 126 grams of dimethyl sulfate in 10 cc portions while the temperature is maintained at about 50°C by external cooling. The mixture is then heated briefly to boiling, cooled, diluted with about 500 cc of water and extracted with two 250 cc portions of benzene. The benzene extract is separated, washed once with sodium bicarbonate solution and once with water. The benzene is removed by evaporation on a steam bath and the residue is fractionally distilled. The material boiling at 112° to 116°C at 25 mm pressure is taken; nD25=1.4495. Upon further fractionation, a very pure specimen boils at 101°-102°C at 11 mm.
The 5-methyl-5-ethyloxazolidine-2,4-dionemay be prepared by reacting methyl ethyl ketone with sodium cyanide and with ammonium thiocyanate followed by desulfurization. This intermediate may also be prepared by condensing α-hydroxy-α-methylbutyramide with ethyl chlorocarbonate or by condensing ethyl α-hydroxy-α-methylbutyrate with urea. Another method described (Traube and Aschar, Ber., 46, 2077-1913) consists in the condensation of ethyl α-hydroxy-α-methylbutyrate with guanidine followed by hydrolysis.

brand name

Paradione (Abbott).

Therapeutic Function

Anticonvulsant

Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. Experimental teratogenic effects. Other experimental reproductive effects. Whenheated to decomposition it emits toxic fumes of NOx.

Synthesis

Paramethadione, 5-ethyl-3,5-dimethyloxazolidine-2,4-dione (9.8.3), differs from trimethadione only in the substitution of one methyl group with an ethyl group. It is synthesized in a completely analogous manner, except that it comes from 2-hydroxy-2-methylbutyric acid instead of 2-hydroxyisobutyric acid [29].

PARAMETHADIONE (500 MG) Preparation Products And Raw materials

Raw materials

Preparation Products

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PARAMETHADIONE (500 MG) Suppliers

China 16 India 3 South Korea 1 United Kingdom 1 United States 4 Global 25

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9823
Advantage: 79

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12338
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 29016
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 15093356674;
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30255
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-81124267 15229202216
Fax: 029-88380327
Email: 1073@dideu.com
Country: China
ProdList: 10011
Advantage: 58

Shaanxi DIDU pharmaceutical and Chemical Co., Ltd

Tel: 17691182729 18161915376
Email: 1046@dideu.com
Country: China
ProdList: 10008
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24131
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354
Email: support@targetmol.com
Country: United States
ProdList: 19973
Advantage: 58

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View Lastest Price from PARAMETHADIONE (500 MG) manufacturers

Dideu Industries Group Limited

Product: PARAMETHADIONE (500 MG) 115-67-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-22

115-67-3, PARAMETHADIONE (500 MG)Related Search:

PARAMETHADIONE (500 MG) 2,4-Oxazolidinedione, 3-(3,5-dichlorophenyl)-5-methyl-5-oxiranyl- vinzolidine 5,5-Dimethyloxazolidine-2,4-dione 5-METHYL-2,4-OXAZOLIDINEDIONE 3,5,5-TRIMETHYLOXAZOLIDINE-2,4-DIONE 2,4-OXAZOLIDINEDIONE 3-(2-AMINO-ETHYL)-1-OXA-3-AZA-SPIRO[4.4]NONANE-2,4-DIONE HYDROCHLORIDE

Isethadionum

5-ethyl-3,5-dimethyl-oxazolidine-2,4-quinone

Paradione

Parametadione

Paramethadione

Paramethodione

2,4-Oxazolidinedione, 5-ethyl-3,5-dimethyl-

3,5-dimethyl-5-ethyloxazolidine-2,4-dione

5-Ethyl-3,5-dimethyl-1,3-oxazolidine-2,4-dione

5-Ethyl-3,5-dimethyl-2,4-oxazolidinedione

5-ethyl-3,5-dimethyl-4-oxazolidinedione

5-Ethyl-3,5-dimethyloxazolidine-2,4-dione

5-ethyl-3,5-dimethyloxazolidine-2.4-dione

A 348

a348

Isoethadione

PARAMETHADIONE (500 MG)

PARAMETHADIONE (500 MG) USP/EP/BP

Paramethadione (1497000)

BRN 0127715

HSDB 3245

Paramethadionum

Nicotinamide Impurity 215

115-67-3