5-FLUORO-1,3-BENZOXAZOL-2(3H)-ONE
- Product Name
- 5-FLUORO-1,3-BENZOXAZOL-2(3H)-ONE
- CAS No.
- 13451-79-1
- Chemical Name
- 5-FLUORO-1,3-BENZOXAZOL-2(3H)-ONE
- Synonyms
- 5-Fluorobenzoxazolone;5-FLUORO-2(3H)-BENZOXAZOLONE;5-Fluorobenzoxazol-2(3H)-one;2(3H)-Benzoxazolone, 5-fluoro-;5-Fluoro-2(3H)-benzoxazolone 96%;5-fluoro-3H-1,3-benzoxazol-2-one;5-FLUORO-2(3H)-BENZOXAZOLONE, 96%;5-Fluoro-2(3H)-benzoxazolone;JRH-07609, 5-Fluorobenzo[d]oxazol-2(3H)-one, 97%
- CBNumber
- CB9501065
- Molecular Formula
- C7H4FNO2
- Formula Weight
- 153.11
- MOL File
- 13451-79-1.mol
5-FLUORO-1,3-BENZOXAZOL-2(3H)-ONE Property
- Melting point:
- 173-177 °C
- Density
- 1.440±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- pka
- 8.29±0.70(Predicted)
- Appearance
- Yellow to orange Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 683264
- Product name
- 5-Fluoro-2(3H)-benzoxazolone
- Purity
- 96%
- Packaging
- 1g
- Price
- $70.6
- Updated
- 2023/01/07
- Product number
- F597370
- Product name
- 5-Fluoro-1,3-benzoxazol-2(3H)-one
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- Z9761
- Product name
- 5-Fluoro-1,3-benzoxazol-2(3h)-one
- Packaging
- 25g
- Price
- $698
- Updated
- 2021/12/16
- Product number
- COR0003349
- Product name
- 5-FLUOROBENZO[D]OXAZOL-2(3H)-ONE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $160.65
- Updated
- 2021/12/16
- Product number
- CD11290764
- Product name
- 5-Fluorobenzo[d]oxazol-2(3H)-one
- Purity
- 95+%
- Packaging
- 10g
- Price
- $203
- Updated
- 2021/12/16
5-FLUORO-1,3-BENZOXAZOL-2(3H)-ONE Chemical Properties,Usage,Production
Synthesis
399-97-3
530-62-1
13451-79-1
The general procedure for the synthesis of 5-fluorobenzo[d]oxazol-2(3H)-ones from 2-amino-4-fluorophenol and N,N'-carbonyldiimidazole (CDI) is as follows: 2-amino-4-fluorophenol (1 eq.) was dissolved with N,N'-carbonyldiimidazole (1.2 eq.) in DMF under the protection of nitrogen, and the reaction was stirred for 5 hr at 80 °C. After completion of the reaction, the mixture was cooled to room temperature and the reaction was quenched by the addition of water. The reaction mixture was extracted with ethyl acetate, the organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography to afford the target compounds 5-fluorobenzo[d]oxazol-2(3H)-one (4a-d).
References
[1] European Journal of Medicinal Chemistry, 2017, vol. 138, p. 199 - 211
[2] Patent: WO2005/18529, 2005, A2. Location in patent: Page/Page column 62
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 23, p. 9258 - 9272
[4] Organic and Biomolecular Chemistry, 2017, vol. 15, # 19, p. 4058 - 4063
[5] Patent: WO2005/18529, 2005, A2. Location in patent: Page/Page column 62
5-FLUORO-1,3-BENZOXAZOL-2(3H)-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
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