ChemicalBook > CAS DataBase List > CHK2 INHIBITOR II

CHK2 INHIBITOR II

Product Name
CHK2 INHIBITOR II
CAS No.
516480-79-8
Chemical Name
CHK2 INHIBITOR II
Synonyms
C 3742;BML-277;CS-1761;BML-277, >98%;Chk2InhibitorⅡ;BML-277 (C 3742);C 3742 BML-277;BML-277,CHK2 INHIBITOR II;Chk2 Inhibitor II hydrate;Chk2 Inhibitor II (BML-277)
CBNumber
CB9503256
Molecular Formula
C20H14ClN3O2
Formula Weight
363.8
MOL File
516480-79-8.mol
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CHK2 INHIBITOR II Property

Boiling point:
637.1±63.0 °C(Predicted)
Density 
1.390±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 18 mg/mL
form 
solid
pka
10.40±0.10(Predicted)
color 
tan
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
220486
Product name
Chk2 Inhibitor II
Packaging
1mg
Price
$172
Updated
2024/03/01
Sigma-Aldrich
Product number
220491
Product name
InSolution? Chk2 Inhibitor II
Packaging
5mg
Price
$280
Updated
2023/01/07
Cayman Chemical
Product number
17552
Product name
Chk2 Inhibitor II
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17552
Product name
Chk2 Inhibitor II
Purity
≥98%
Packaging
5mg
Price
$93
Updated
2024/03/01
Sigma-Aldrich
Product number
C3742
Product name
Chk2 Inhibitor II hydrate
Purity
≥98% (HPLC)
Packaging
5mg
Price
$220
Updated
2024/03/01
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CHK2 INHIBITOR II Chemical Properties,Usage,Production

Description

Chk2 inhibitor II is a selective, ATP-competitive inhibitor of the DNA damage control kinase, checkpoint kinase 2 (IC50 = 15 nM). It has been shown to prevent apoptosis in human T-cells exposed to ionizing radiation (EC50 = 3-7.6 μM). This compound has been used to target the role of Chk2 in cellular signaling in response to DNA damage.

Uses

Chk2 Inhibitor II is a selective APT-competitive inhibitors of the DNA damage response signaling enzyme checkpoint kinase 2 (CHK2).

Biochem/physiol Actions

Chk2 Inhibitor II is a checkpoint kinase 2 inhibitor, which controls the p53 response to DNA breaks induced by radiation, leading to apoptosis. Protection of T-cells from apoptosis implies use as an adjuvant for radiation therapy in cancer. IC50 = 15 nM; Ki = 37 nM. Chk2 Inhibitor II shows 1000-fold greater selectivity for the Chk2 serine/threonine kinase than for the Cdk1/B and CK1 kinases (for which IC50 = 12 μM and 17 μM, respectively). Chk2 Inhibitor II weakly inhibits a panel of 31 other kinases (<25% inhibition at a concentration of 10 μM and prevents apoptosis of human CD4+ and CD8+ T-cells subjected to ionizing radiation (EC50 = 3 μM and 7.6 μM, respectively).

References

1) Arienti et al. (2005), Checkpoint kinases inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles; J. Med. Chem., 48 1873 2) Pereg et al. (2006), Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage; Mol. Cell. Biol., 26 6819

CHK2 INHIBITOR II Preparation Products And Raw materials

Raw materials

Preparation Products

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CHK2 INHIBITOR II Suppliers

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View Lastest Price from CHK2 INHIBITOR II manufacturers

Career Henan Chemical Co
Product
CHK2 INHIBITOR II 516480-79-8
Price
US $1.00/KG
Min. Order
1KG
Purity
95%~99%
Supply Ability
per week:100kg
Release date
2019-09-05

516480-79-8, CHK2 INHIBITOR IIRelated Search:

DMOG 5-Fluorouracil 8-OXO-2'-DEOXYGUANOSINE 3-Aminobenzamide Debromo Hymenialdisine

  • 2-(4-(4-CHLOROPHENOXY)PHENYL)-1H-BENZO[D]IMIDAZOLE-5-CARBOXAMIDE, >98%
  • BML-277, >98%
  • BML-277 (C 3742)
  • CS-1761
  • BML-277,CHK2 INHIBITOR II
  • CHK2 INHIBITOR II; C 3742; BML277; BML 277
  • Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem
  • InSolution Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem
  • 2-[4-(4-chlorophenoxy)phenyl]-3H-benzimidazole-5-carboxamide
  • C 3742
  • BML-277
  • 2-(4-(4-CHLOROPHENOXY)PHENYL)-1H-BENZO[D]IMIDAZOLE-5-CARBOXAMIDE
  • 2-[4-(4-Chlorophenoxy)phenyl]-1H-benzimidazole-5-carboxylic acid amide
  • C 3742 BML-277
  • InSolution? Chk2 Inhibitor II
  • 2-[4-(4-chlorophenoxy)phenyl]-1H-benzimidazole-6-carboxamide
  • 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide hydrate
  • Chk2 Inhibitor II hydrate
  • Chk2 Inhibitor II (BML-277)
  • 1H-Benzimidazole-6-carboxamide, 2-[4-(4-chlorophenoxy)phenyl]-
  • 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzo[d]imidazole-6-carboxamide
  • inhibit,Checkpoint Kinase (Chk),Inhibitor,BML277,BML-277,Apoptosis
  • Chk2InhibitorⅡ
  • 516480-79-8
  • Inhibitors
  • API