ChemicalBook > CAS DataBase List > RO 48-8071

RO 48-8071

Product Name: RO 48-8071
CAS No.: 189197-69-1
Chemical Name: RO 48-8071
Synonyms: CS-1750;Aids163155;Aids-163155;Ro 48-8071 fumarate salt;OSC Inhibitor, Ro 48-8071;RO 488071;RO48-8071;RO-48-8071;Ro 48-8071 fumarate, 10 mM in DMSO;Ro 48-8071 fumarate (Ro-488071 fumarate);Ro 48-8071, 2,3-oxidosqualene cyclase (OSC) inhibitor;OSC Inhibitor, Ro 48-8071 - CAS 189197-69-1 - Calbiochem
CBNumber: CB9504369
Molecular Formula: C23H27BrFNO2.C4H4O4
Formula Weight: 564.45
MOL File: 189197-69-1.mol

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RO 48-8071 Property

Melting point:: 90-92.7 °C
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: H₂O: >5 mg/mL at ~60 °C
form: solid
color: white
Water Solubility: water: 5mg/mL

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 499635
Product name: OSC Inhibitor, Ro 48-8071
Packaging: 10mg
Price: $155
Updated: 2025/07/31

TRC

Product number: R700973
Product name: Ro48-8071Fumarate
Packaging: 50mg
Price: $380
Updated: 2021/12/16

ApexBio Technology

Product number: B4860
Product name: Ro48-8071fumarate
Packaging: 100mg
Price: $394
Updated: 2021/12/16

ApexBio Technology

Product number: B4860
Product name: Ro48-8071fumarate
Packaging: 50mg
Price: $236
Updated: 2021/12/16

AK Scientific

Product number: 4012AH
Product name: (4-Bromophenyl)-[2-fluoro-4-[6-[methyl(prop-2-enyl)amino]hexoxy]phenyl]methanone,(E)-but-2-enedioicacid
Packaging: 5mg
Price: $113
Updated: 2021/12/16

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RO 48-8071 Chemical Properties,Usage,Production

Uses

Ro 48-8071 fumarate is an inhibitor of OSC (Oxidosqualene cyclase) with IC50 of appr 6.5 nM.

Definition

ChEBI: A fumarate salt obtained by combining Ro 48-8071 with one molar equivalent of fumaric acid. An inhibitor of lanosterol synthase.

in vivo

Ro 48-8071 lowers LDL-C maximally appr 60% at 150 μmol/kg per day, with no further reduction up to 300 μmol/kg per day, leaving HDL-C unchanged at all doses in hamsters. Ro 48-8071 (≥00 μmol/kg per day) increases the amount of MOS in liver of hamsters. Ro 48-8071 (300 μmol/kg per day) remarkedly and significantly reduces VLDL secretion of hamsters^[1]. Ro 48-8071 (5 or 20 mg/kg) significantly reduces in vivo tumor growth in mice, without weight loss of the mice. Furthermore, Ro 48-8071 at a concentration of 20 mg/kg, completely eradicates two of the 12 tumors being monitored in the mice in the timeframe tested^[2]. Ro 48-8071 (20 mg/day/kg body weight) leads to a rapid and sustained inhibition (>50%) of cholesterol synthesis in the whole small intestine of BALB/c mice. Sterol synthesis is also reduced in the large intestine and stomach^[4].

storage

Store at +4°C

References

[1] Morand OH, et al. Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin. J Lipid Res. 1997 Feb;38(2):373-90. PMID:9162756
[2] Liang Y, et al. Cholesterol biosynthesis inhibitor RO 48-8071 suppresses growth of hormone-dependent and castration-resistant prostate cancer cells. Onco Targets Ther. 2016 May 30;9:3223-32 DOI:10.2147/OTT.S105725
[3] Liang Y, et al. Cholesterol biosynthesis inhibitors as potent novel anti-cancer agents: suppression of hormone-dependent breast cancer by the oxidosqualene cyclase inhibitor RO 48-8071. Breast Cancer Res Treat. 2014 Jul;146(1):51-62. DOI:10.1007/s10549-014-2996-5
[4] Chuang JC, et al. Sustained and selective suppression of intestinal cholesterol synthesis by Ro 48-8071, an inhibitor of 2,3-oxidosqualene:lanosterol cyclase, in the BALB/c mouse. Biochem Pharmacol. 2014 Apr 1;88(3):351-63. DOI:10.1016/j.bcp.2014.01.031

RO 48-8071 Preparation Products And Raw materials

Raw materials

Preparation Products

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RO 48-8071 Suppliers

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189197-69-1, RO 48-8071Related Search:

BIBB 515 U 18666A

(4-Bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]methanone

Methanone, (4-bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]-, (2E)-2-butenedioate (1:1)

OSC Inhibitor, Ro 48-8071 - CAS 189197-69-1 - Calbiochem

RO 488071;RO48-8071;RO-48-8071

CS-1750

Ro 48-8071 fumarate salt

(4-((6-(allyl(methyl)amino)hexyl)oxy)-2-fluorophenyl)(4-bromophenyl)methanone fumarate Ro48-8071

(4-Bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]methanone (2E)-2-butenedioate (1:1)

OSC Inhibitor, Ro 48-8071

Aids163155

Aids-163155

Methanone, (4-bromophenyl)[2-fluoro-4-[[6-(methyl-2-propenylamino)hexyl]oxy]phenyl]-,(2E)-2-butenedioate

Ro 488071 fumarate,Ro 48 8071 fumarate,Ro 48-8071,Inhibitor,inhibit

Ro 48-8071, 2,3-oxidosqualene cyclase (OSC) inhibitor

Ro 48-8071 fumarate, 10 mM in DMSO

4′-[6-(Allylmethylamino)hexyloxy]-4-bromo-2′-fluorobenzophenone fumarate

Ro 48-8071 fumarate (Ro-488071 fumarate)

189197-69-1

C27H31BrFNO6

C23H27BrFNO2C4H4O4

C23H27NO2BrFC4H4O4

Inhibitors