ChemicalBook > CAS DataBase List > PROTOPANAXTRIOL

PROTOPANAXTRIOL

Product Name: PROTOPANAXTRIOL
CAS No.: 34080-08-5
Chemical Name: PROTOPANAXTRIOL
Synonyms: g-PPT;20(S)-APPT;PROTOPANAXTRIOL;S-Protopanaxatriol;PROTOPANAXADIOL(RG);Protopanaxatriol-RM;Protopanaxtriol ,98%;20(S)-Protopanaxtriol;(2S)-Protopanaxatriol;Protopanaxatriol, 20S-
CBNumber: CB9511866
Molecular Formula: C30H52O4
Formula Weight: 476.74
MOL File: 34080-08-5.mol

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PROTOPANAXTRIOL Property

Melting point:: 242-244 °C
Boiling point:: 590.0±50.0 °C(Predicted)
Density: 1.079
storage temp.: -20°C Freezer
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 14.73±0.70(Predicted)
color: Off-White
InChIKey: SHCBCKBYTHZQGZ-NSMZZYIQNA-N
LogP: 5.890 (est)

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Safety

WGK Germany: 3
HS Code: 29061990

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29073
Product name: 20(S)-Protopanaxatriol
Packaging: 5mg
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 29073
Product name: 20(S)-Protopanaxatriol
Packaging: 25mg
Price: $510
Updated: 2024/03/01

Cayman Chemical

Product number: 29073
Product name: 20(S)-Protopanaxatriol
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 29073
Product name: 20(S)-Protopanaxatriol
Packaging: 10mg
Price: $223
Updated: 2024/03/01

TRC

Product number: P838855
Product name: (20S)-Protopanaxatriol(~91%HPLC)
Packaging: 100mg
Price: $435
Updated: 2021/12/16

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PROTOPANAXTRIOL Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from ginseng.

Uses

(20S)-Protopanaxatriol acts as an inhibitor in the production of corticosteroids in fasciculata cells. Used in the clinical treatment of heart diseases.

Definition

ChEBI: Protopanaxatriol is a tetracyclic triterpenoid sapogenin (isolated from ginseng and notoginseng) that is that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions and in which a double bond has been introduced at the 24-25 position. It has a role as a metabolite. It is a tetracyclic triterpenoid, a sapogenin, a 3beta-hydroxy steroid, a 12beta-hydroxy steroid, a 6alpha-hydroxy steroid and a 3beta-hydroxy-4,4-dimethylsteroid. It derives from a hydride of a dammarane.

Biological Activity

A metabolites of ginsenoside, protopanaxatriol (g-PPT), could modulate endothelial cell functions through the glucocorticoid receptor (GR) and oestrogen receptor (ER).

in vivo

(20S)-Protopanaxatriol (10?mg/kg; i.p.; daily for four weeks) synergizes with Gefitinib to inhibit xenograft growth^[3].
(20S)-Protopanaxatriol (50-100 mg/kg; p.o.; 25 days; female BALB/c nude mice bearing breast cancer MCF-7 cell) inhibits the growth of MCF-7 breast cancer cells in a nude mice xenograft assay^[4].

Animal Model:	H1975 murine xenograft tumor model
Dosage:	10?mg/kg
Administration:	I.p.; daily for four weeks
Result:	The combined g-PPT and Gefitinib (50 mg/kg/day) treatment clearly reduced p-EGFR and KI67 expression and increased c-Caspase3 expression compared to Gefitinib or g-PPT treatment alone.

target

Antifection | Glucocorticoid receptor | Oestrogen receptor | LXRα

PROTOPANAXTRIOL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from PROTOPANAXTRIOL manufacturers

Baoji Guokang Healthchem Co., Ltd.

Product: PROTOPANAXTRIOL 34080-08-5
Price: US $32514.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000kg
Release date: 2021-06-08

Shanghai Standard Technology Co., Ltd.

Product: Protopanaxatriol 34080-08-5
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-09-27

NanJing Spring & Autumn Biological Engineering CO., LTD.

Product: 20(S)-Protopanaxatriol 34080-08-5 34080-08-5
Price: US $25.00/mg
Min. Order: 20mg
Purity: ≥98% by HPLC
Supply Ability: 1000.00 KGS
Release date: 2019-07-03

34080-08-5, PROTOPANAXTRIOLRelated Search:

Ginsenoside Rd Ginsenoside Rg2 Ginsenoside Rh1 PROTOPANAXDIOL GinsenosideRo Ginsenoside Rh2 GINSENOSIDE RB2 Pseudoginsenoside RT5 Ginsenoside RK2 Ginsenoside Rk3 Ginsenoside Rb3 Protopanaxatriol ptaquiloside Protodioscin Protopanaxadiol Ginsenoside Rf GINSENOSIDEF1 PROTOPANAXTRIOL

(20S)-Protopanaxatriol, >98%

20(S)-Protopanaxatriol 34080-08-5

PROTOPANAXTRIOL

PROTOPANAXADIOL(RG)

Protopanaxtriol ,98%

20(S)-Protopanaxtriol(PPT)

20(S)-Protopanaxtriol

(20S)-5α-Dammar-24-ene-3β,6α,12β,20-tetrol

S-Protopanaxatriol

(3b,6a,12b)-Dammar-24-ene-3,6,12,20-tetrol

Dammar-24-ene-3,6,12,20-tetrol, (3beta,6alpha,12beta)-

20(S)-APPT

g-PPT

(2S)-Protopanaxatriol

Protopanaxatriol, 20S-

Dammar-24-ene-3,6,12,20-tetrol, (3β,6α,12β)-

(20S)-Protopanaxatriol (~91% HPLC)

(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-17-[(2R)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,6,12-triol

(20S)-Protopanaxatriol APPT

(20S) Protopanaxatriol,Estrogen Receptor/ERR,Glucocorticoid Receptor,Apoptosis,(20S)-Protopanaxatriol,inhibit,Inhibitor,Liver X receptor,LXR,(20S)Protopanaxatriol

(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-17-((S)-2-Hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,6,12-triol

(20S)-Protopanaxatriol/PPT

Protopanaxatriol-RM

34080-08-5

Inhibitors

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Ginseng series