BI-749327

Product Name: BI-749327
CAS No.: 2361241-23-6
Chemical Name: BI-749327
Synonyms: BI-749327;(4-(6-aminopyridazin-3-yl)piperidin-1-yl)(4-(4-(trifluoromethyl)phenoxy)phenyl)methanone;Methanone, [4-(6-amino-3-pyridazinyl)-1-piperidinyl][4-[4-(trifluoromethyl)phenoxy]phenyl]-;BI749327,Inhibitor,BI-749327,inhibit,Transient receptor potential channels,BI 749327,TRP Channel
CBNumber: CB95419686
Molecular Formula: C23H21F3N4O2
Formula Weight: 442.43
MOL File: 2361241-23-6.mol

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BI-749327 Property

Boiling point:: 637.5±55.0 °C(Predicted)
Density: 1.334±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (25 mg/ml)
pka: 5.26±0.10(Predicted)
form: solid
color: White
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0094062
Product name: BI-749327
Purity: 99.53%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0094062
Product name: BI-749327
Purity: 99.53%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0094062
Product name: BI-749327
Purity: 99.53%
Packaging: 50mg
Price: $1650
Updated: 2021/12/16

ChemScene

Product number: CS-0094062
Product name: BI-749327
Purity: 99.53%
Packaging: 100mg
Price: $2650
Updated: 2021/12/16

DC Chemicals

Product number: DC42750
Product name: BI-749327
Purity: >98%
Packaging: 1g
Price: $2400
Updated: 2021/12/16

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BI-749327 Chemical Properties,Usage,Production

Description

BI 749327 (2361241-23-6) is a potent (IC50 = 13 nM mouse TRPC6, 19 nM human TRPC6) and selective (85-fold over TRPC3, 42-fold over TRC7) orally available blocker of TRPC6.1 It suppressed interstitial fibrosis and associated molecular signaling in mouse heart and kidney disease models.? BI 749327 reversed established pulmonary hypertension by 50% via regression of pulmonary remodeling in a mouse model.2

References

Lin et al. (2019) In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease; Proc. Natl. Acad. Sci. USA 116 10156 Jain et al. (2021) TRPC6, a therapeutic target for pulmonary hypertension; Am. J. Physiol. Lung Cell. Mol. Physiol. 321 L1161

BI-749327 Preparation Products And Raw materials

Raw materials

Preparation Products

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BI-749327 Suppliers

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(4-(6-aminopyridazin-3-yl)piperidin-1-yl)(4-(4-(trifluoromethyl)phenoxy)phenyl)methanone

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