ChemicalBook > CAS DataBase List > BI-749327

BI-749327

Product Name
BI-749327
CAS No.
2361241-23-6
Chemical Name
BI-749327
Synonyms
BI-749327;BI-749327, 10 mM in DMSO;(4-(6-aminopyridazin-3-yl)piperidin-1-yl)(4-(4-(trifluoromethyl)phenoxy)phenyl)methanone;Methanone, [4-(6-amino-3-pyridazinyl)-1-piperidinyl][4-[4-(trifluoromethyl)phenoxy]phenyl]-;BI749327,Inhibitor,BI-749327,inhibit,Transient receptor potential channels,BI 749327,TRP Channel
CBNumber
CB95419686
Molecular Formula
C23H21F3N4O2
Formula Weight
442.43
MOL File
2361241-23-6.mol
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BI-749327 Property

Boiling point:
637.5±55.0 °C(Predicted)
Density 
1.334±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO (25 mg/ml)
pka
5.26±0.10(Predicted)
form 
solid
color 
White
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0094062
Product name
BI-749327
Purity
99.53%
Packaging
5mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0094062
Product name
BI-749327
Purity
99.53%
Packaging
10mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0094062
Product name
BI-749327
Purity
99.53%
Packaging
50mg
Price
$1650
Updated
2021/12/16
ChemScene
Product number
CS-0094062
Product name
BI-749327
Purity
99.53%
Packaging
100mg
Price
$2650
Updated
2021/12/16
DC Chemicals
Product number
DC42750
Product name
BI-749327
Purity
>98%
Packaging
1g
Price
$2400
Updated
2021/12/16
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BI-749327 Chemical Properties,Usage,Production

Description

BI 749327 (2361241-23-6) is a potent (IC50 = 13 nM mouse TRPC6, 19 nM human TRPC6) and selective (85-fold over TRPC3, 42-fold over TRC7) orally available blocker of TRPC6.1 It suppressed interstitial fibrosis and associated molecular signaling in mouse heart and kidney disease models.? BI 749327 reversed established pulmonary hypertension by 50% via regression of pulmonary remodeling in a mouse model.2

References

Lin et al. (2019) In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease; Proc. Natl. Acad. Sci. USA 116 10156 Jain et al. (2021) TRPC6, a therapeutic target for pulmonary hypertension; Am. J. Physiol. Lung Cell. Mol. Physiol. 321 L1161

BI-749327 Preparation Products And Raw materials

Raw materials

Preparation Products

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BI-749327 Suppliers

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2361241-23-6, BI-749327Related Search:

METHOPRENE ACID Levetiracetam Pomalidomide Imiquimod

  • BI-749327
  • Methanone, [4-(6-amino-3-pyridazinyl)-1-piperidinyl][4-[4-(trifluoromethyl)phenoxy]phenyl]-
  • BI749327,Inhibitor,BI-749327,inhibit,Transient receptor potential channels,BI 749327,TRP Channel
  • (4-(6-aminopyridazin-3-yl)piperidin-1-yl)(4-(4-(trifluoromethyl)phenoxy)phenyl)methanone
  • BI-749327, 10 mM in DMSO
  • 2361241-23-6